Whole body exposure with GSM 900MHz affects spatial memory in mice

Fragopoulou, Adamantia F.; Miltiadous, Panagiota; Stamatakis, Antonios; Stylianopoulou, Fotini; Koussoulakos, S.; Margaritis, Lukas H.

doi:10.1016/j.pathophys.2009.11.002

Cited by 67 publications

(45 citation statements)

References 55 publications

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“…Study conducted by Lai and Sigh (1999) lead to the conclusion that spatial orientation can be disturbed when SAR values are below 1 W/kg (22). It has been recently reported that GSM 900 MHz radiation (SAR 0.41-0.98 W/kg) causes defi cits in consolidation and/or retrieval of the learned spatial information (23). On the other hand, Jadidi et al (2009) reported the opposite fi ndings on this matter, therefore further investigation regarding this problem is needed (1).…”

Section: Discussionmentioning

confidence: 99%

The effect of melatonin on body mass and behaviour of rats during an exposure to microwave radiation from mobile phone

Djordjević¹,

Kocić²,

Babović³

et al. 2012

BLL

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Abstract:Background: Microwave radiation (MW) produced by wireless telecommunications and a number of electrical devices used in household or in healthcare institutions may cause various disorders in human organism. On the other hand, melatonin is a potent antioxidant, immunostimulator and neuromodulator. The aim of this research was to determine body mass and behaviour changes in rats after a chronic microwave exposure, as well as to determine the effects of melatonin on body mass and behaviour in irradiated rats. Methods: Wistar rats were divided into the four experimental groups: I group (control) -rats treated with 0,9 % saline, II group (Mel) -rats treated with melatonin (2 mg/kg), III group (MW) -rats exposed to MW radiation (4 h/day), IV group (MW+Mel) -rats, which were both exposed to MW radiation and received melatonin premedication (2 mg/kg). Results: A signifi cant body mass reduction was noted in animals exposed to MW radiation when compared to controls after 20, 40 and 60 days (p<0.001). Furthermore, body weight was signifi cantly increased (p<0.05) in irradiated rats, which received melatonin pretreatment (MW+Mel) in comparison to irradiated group (MW) after 20 days. Microwave radiation exposed animals showed an anxiety related behaviour (agitation, irritability) after 10 days of exposure. After the radiation source removal, changes in behaviour were less noticeable. Melatonin administration to irradiated rats caused a decrease in the stress induced behaviour. Conclusion: Microwave radiation causes body mass decrease and anxiety related behaviour in rats, however melatonin causes a reverse of those effects on both body weight and behaviour of irradiated animals (Fig. 2

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Section: Discussionmentioning

confidence: 99%

The effect of melatonin on body mass and behaviour of rats during an exposure to microwave radiation from mobile phone

Djordjević¹,

Kocić²,

Babović³

et al. 2012

BLL

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“…Lastly, at both ages, GFAP and IL in the hippocampus and sub-cortical nuclei, including key structures implicated in the fear conditioning paradigm, were not subjected to GSM or age effects. More generally, current literature is characterized by discordant GSM effects on memory (positive effects: (Fragopoulou et al, 2010;Narayanan et al, 2009) ; negative results: (Ammari et al, 2008;Dubreuil et al, 2002)), which may be explained by the weakness or specificity of GSM action in particular protocols or types of memory processes.…”

Section: Gsm Exposure Stress and Emotional Memorymentioning

confidence: 99%

“…GSM effects on IL expression have only been assessed in one in vitro study (Thorlin et al, 2006), while no in vivo animal studies have been published yet. GSM exposure was shown to affect plasmatic CORT levels (Mostafa et al, 2002) and to impair learning and memory (Fragopoulou et al, 2010;Narayanan et al, 2009). …”

Section: Introductionmentioning

confidence: 99%

Effects of 900MHz radiofrequency on corticosterone, emotional memory and neuroinflammation in middle-aged rats

Bouji¹,

Lecomte²,

Hode³

et al. 2012

Experimental Gerontology

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. Effects of 900 MHz radiofrequency on corticosterone, emotional memory and neuroinflammation in middle-aged rats. Experimental Gerontology, Elsevier, 2012, 47 (6) ABSTRACTThe widespread use of mobile phones raises the question of the effects of electromagnetic fields (EMF, 900 MHz) on the brain. Previous studies reported increased levels of the glial fibrillary acidic protein (GFAP) in the rat's brain after a single exposure to 900 MHz global system for mobile (GSM) signal, suggesting a potential inflammatory process. While this result was obtained in adult rats, no data is currently available in older animals. Since the transition from middle-age to senescence is highly dependent on environment and lifestyle, we studied the reactivity of middle-aged brains to EMF exposure. We assessed the effects of a single 15 min GSM exposure (900MHz; specific absorption rate (SAR) = 6 W/kg) on GFAP expression in young adults (6 week-old) and middle-aged rats (12 month-old). Brain interleukin (IL)-1β and IL-6, plasmatic levels of corticosterone (CORT), and emotional memory were also assessed.Our data indicated that, in contrast to previously published work, acute GSM exposure did not induce astrocytes activation. Our results showed an IL-1β increase in the olfactory bulb and enhanced contextual emotional memory in GSM-exposed middle-aged rats, and increased plasmatic levels of CORT in GSM-exposed young adults. Altogether, our data showed an age dependency of reactivity to GSM exposure in neuroimmunity, stress and behavioral parameters. Reproducing these effects and studying their mechanisms may allow a better understanding of mobile phone EMF effects on neurobiological parameters.

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“…Kumlin et al (2007) have reported that, 900 MHz exposure (2 h/day, 5 days/week for 5 weeks), did enhance spatial memory performance and it did not affect hippocampal morphology in rats. On the other hand Fragopoulou et al (2010) have found that, 2 h daily dose of 900 MHz radiation (pulsed GSM) from a mobile phone for 4 days induced altered spatial memory performance in mice. Another report suggest that, a single 15 min 900 MHz radiation (GSM; SAR=6 W/kg) exposure did not induce astrocyte activation but increased IL-1β in the olfactory bulb and enhanced contextual emotional memory in GSM-exposed middle-aged rats (Bouji et al 2012).…”

Section: Introductionmentioning

confidence: 99%

Possible cause for altered spatial cognition of prepubescent rats exposed to chronic radiofrequency electromagnetic radiation

et al. 2015

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The effects of chronic and repeated radiofrequency electromagnetic radiation (RFEMR) exposure on spatial cognition and hippocampal architecture were investigated in prepubescent rats. Four weeks old male Wistar rats were exposed to RF-EMR (900 MHz; SAR-1.15 W/kg with peak power density of 146.60 μW/cm(2)) for 1 h/day, for 28 days. Followed by this, spatial cognition was evaluated by Morris water maze test. To evaluate the hippocampal morphology; H&E staining, cresyl violet staining, and Golgi-Cox staining were performed on hippocampal sections. CA3 pyramidal neuron morphology and surviving neuron count (in CA3 region) were studied using H&E and cresyl violet stained sections. Dendritic arborization pattern of CA3 pyramidal neuron was investigated by concentric circle method. Progressive learning abilities were found to be decreased in RF-EMR exposed rats. Memory retention test performed 24 h after the last training revealed minor spatial memory deficit in RF-EMR exposed group. However, RF-EMR exposed rats exhibited poor spatial memory retention when tested 48 h after the final trial. Hirano bodies and Granulovacuolar bodies were absent in the CA3 pyramidal neurons of different groups studied. Nevertheless, RF-EMR exposure affected the viable cell count in dorsal hippocampal CA3 region. RF-EMR exposure influenced dendritic arborization pattern of both apical and basal dendritic trees in RF-EMR exposed rats. Structural changes found in the hippocampus of RF-EMR exposed rats could be one of the possible reasons for altered cognition.

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Whole body exposure with GSM 900MHz affects spatial memory in mice

Cited by 67 publications

References 55 publications

The effect of melatonin on body mass and behaviour of rats during an exposure to microwave radiation from mobile phone

The effect of melatonin on body mass and behaviour of rats during an exposure to microwave radiation from mobile phone

Effects of 900MHz radiofrequency on corticosterone, emotional memory and neuroinflammation in middle-aged rats

Possible cause for altered spatial cognition of prepubescent rats exposed to chronic radiofrequency electromagnetic radiation

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