Robotics is a crucial technology of Industry 4.0 that offers a diverse array of applications in the industrial sector. However, the quality of a robot’s manipulator is contingent on its stability, which is a function of the manipulator’s parameters. In previous studies, stability has been evaluated based on a small number of manipulator parameters; as a result, there is not much information about the integration/optimal arrangement/combination of manipulator parameters toward stability. Through Lagrangian mechanics and the consideration of multiple parameters, a mathematical model of a modern manipulator is developed in this study. In this mathematical model, motor acceleration, moment of inertia, and deflection are considered in order to assess the level of stability of the ABB Robot manipulator of six degrees of freedom. A novel mathematical approach to stability is developed in which stability is correlated with motor acceleration, moment of inertia, and deflection. In addition to this, fuzzy logic inference principles are employed to determine the status of stability. The numerical data of different manipulator parameters are verified using mathematical approaches. Results indicated that as motor acceleration increases, stability increases, while stability decreases as moment of inertia and deflection increase. It is anticipated that the implementation of these findings will increase industrial output.