Whole body periodic acceleration (pGz) preserves heart rate variability after cardiac arrest

Adams, José A.; Uryash, Arkady; Berg, Robert A.; López, José R.

doi:10.1016/j.resuscitation.2015.11.018

Cited by 5 publications

(4 citation statements)

References 42 publications

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“…nNOS has sympathoinhibitory effects under physiological conditions by acting on different sites of the nervous system, including paraventricular nucleus, nucleus of the solitary tract, rostral ventral medulla, the carotid body, and nerves in the kidney [ 32 – 34 ]. nNOS inhibition via a selective nNOS inhibitor 1-2 trifluoromethyl imidazole (TRIM) or using nNOS knockout mice markedly decreases HRV [ 13 , 35 ]. In humans who received NO donor drugs or l-arginine, there has been enhanced cardiac vagal control [ 36 ].…”

Section: Discussionmentioning

confidence: 99%

“…We previously showed that addition of pulses to the circulation through whole body periodic acceleration increases heart rate variability in swine postcardiac arrest [ 13 ]. Here, we report on portable passive simulated jogging device (JD) that adds pulses to the circulation through passive tapping of the forefoot on motorized pedals that rise and as they strike a semirigid bumper to simulate the feet striking the ground with locomotion.…”

Section: Introductionmentioning

confidence: 99%

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The Effects of Passive Simulated Jogging on Short-Term Heart Rate Variability in a Heterogeneous Group of Human Subjects

Adams

Patel

López³

et al. 2018

Journal of Sports Medicine

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Background Heart rate variability (HRV) reflects neural balance between sympathetic and parasympathetic autonomic nervous systems (ANS). Reduced HRV occurs in several chronic diseases and physical inactivity. External addition of pulses to the circulation restores HRV. A new method to add pulses to the circulation can be accomplished with a passive simulated jogging device (JD). We hypothesized that application of JD might increase HRV in seated and supine postures in a heterogeneous group of volunteer subjects. Methods Twenty ambulatory persons (age range 31-88) were recruited. The physical activity intervention (JD) moved the feet in a repetitive and alternating manner; upward movement of the pedal is followed by a downward movement of the forefoot tapping against a semirigid bumper to simulate tapping of feet against the ground during jogging. Each subject underwent four, 30 min sessions in seated and supine postures with the active JD and same with Sham. HRV was assessed at baseline (BL), and Recovery (REC) from analysis of an electrocardiogram. Time domain variables were computed, namely, standard deviation of all normal RR intervals (SDNN) and square root of the mean of the sum of the squares of differences between adjacent RR intervals (RMSSD). Frequency domain measures were determined using a standard Fast Fourier spectral analysis, as well as parameters of Poincaré plots. Results Thirty minutes of JD significantly increased time domain measures and Poincaré parameters of HRV in both seated and supine postures. Frequency domain parameters showed no change. The effects of JD on HRV measures were not affected by age, gender, or posture. Conclusion The passive simulated jogging device increased HRV in both seated and supine postures. This intervention that provided effortless physical activity is a novel method to harness the beneficial effects of increasing HRV.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The Effects of Passive Simulated Jogging on Short-Term Heart Rate Variability in a Heterogeneous Group of Human Subjects

Adams

Patel

López³

et al. 2018

Journal of Sports Medicine

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“…Before cardiac arrest happens, it is often accompanied with progressive deterioration of vital signs, such as obviously decline of heart rate and SPO2. [17] If we can identify them in time and start CPR as soon as possible, the success rate of CPR will be improved obviously. Heart rate can reflect the electrical activity of the heart and SPO2 can reflect the perfusion of the recovered tissue.…”

Section: Discussionmentioning

confidence: 99%

The related factors for the recovery and maintenance time of sinus rhythm in hospitalized patients with cardiopulmonary resuscitation

Wang²,

Zhang³

et al. 2019

Medicine

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“…Specifically, neuronal nitric oxide synthase (nNOS), which has sympathoinhibitory effects under physiological conditions by acting on different sites of the nervous system, including the paraventricular nucleus, the nucleus of the solitary tract, rostral ventral medulla, the carotid body and nerves in the kidney [60][61][62]. nNOS inhibition via a selective nNOS inhibitor 1-2 trifluoromethyl imidazole (TRIM) or nNOS knockout mice markedly decreased HRV [63,64]. There is enhanced vagal control in humans who received NO donor drugs or l-arginine [65].…”

mentioning

confidence: 99%

A Nonrandomized Trial of the Effects of Passive Simulated Jogging on Short-Term Heart Rate Variability in Type 2 Diabetic Subjects

Adams

López

Banderas³

et al. 2023

Journal of Diabetes Research

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Background. Diabetes mellitus has reached global epidemic proportions, with type 2 diabetes (T2DM) comprising more than 90% of all subjects with diabetes. Cardiovascular autonomic neuropathy (CAN) frequently occurs in T2DM. Heart rate variability (HRV) reflects a neural balance between the sympathetic and parasympathetic autonomic nervous systems (ANS) and a marker of CAN. Reduced HRV has been shown in T2DM and improved by physical activity and exercise. External addition of pulses to the circulation, as accomplished by a passive simulated jogging device (JD), restores HRV in nondiseased sedentary subjects after a single session. We hypothesized that application of JD for a longer period (7 days) might improve HRV in T2DM participants. Methods. We performed a nonrandomized study on ten T2DM subjects (age range 44-73 yrs) who were recruited and asked to use a physical activity intervention, a passive simulated jogging device (JD) for 7 days. JD moves the feet in a repetitive and alternating manner; the upward movement of the pedal is followed by a downward movement of the forefoot tapping against a semirigid bumper to simulate the tapping of feet against the ground during jogging. Heart rate variability (HRV) analysis was performed using an electrocardiogram in each subject in seated posture on day 1 (baseline, BL), after seven days of JD (JD7), and seven days after discontinuation of JD (Post-JD). Time domain variables were computed, viz., standard deviation of all normal RR intervals (SDNN), standard deviation of the delta of all RR intervals (SDΔNN), and the square root of the mean of the sum of the squares of differences between adjacent RR intervals (RMSSD). Frequency domain measures were determined using a standard Fast Fourier spectral analysis, as well as the parameters of the Poincaré plots (SD1 and SD2). Results. Seven days of JD significantly increased SDNN, SDΔNN, RMSSD, and both SD1 and SD2 from baseline values. The latter parameters remained increased Post-JD. JD did not modify the frequency domain measures of HRV. Conclusion. A passive simulated jogging device increased the time domain and Poincaré variables of HRV in T2DM. This intervention provided effortless physical activity as a novel method to harness the beneficial effects of passive physical activity for improving HRV in T2DM subjects.

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Whole body periodic acceleration (pGz) preserves heart rate variability after cardiac arrest

Cited by 5 publications

References 42 publications

The Effects of Passive Simulated Jogging on Short-Term Heart Rate Variability in a Heterogeneous Group of Human Subjects

The Effects of Passive Simulated Jogging on Short-Term Heart Rate Variability in a Heterogeneous Group of Human Subjects

The related factors for the recovery and maintenance time of sinus rhythm in hospitalized patients with cardiopulmonary resuscitation

A Nonrandomized Trial of the Effects of Passive Simulated Jogging on Short-Term Heart Rate Variability in Type 2 Diabetic Subjects

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