2022
DOI: 10.1016/j.apsb.2021.09.016
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Whole-body PET tracking of a d-dodecapeptide and its radiotheranostic potential for PD-L1 overexpressing tumors

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Cited by 19 publications
(25 citation statements)
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“…The syntheses of HKP2201 and HKP2202 precursor peptide and radionuclide labeling were performed according to previously published methods. 23 Briefly, CLP002 was synthesized manually using an Fmoc-based solidphase peptide synthesis strategy, as illustrated in Supplementary Figure 1. 1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) was used as a chelator to generate HKP2201 to label 64 Cu and 68 Ga. For the synthesis of HKP2202, a lysine was used as a linker to add the other CLP002.…”
Section: ■ Experimental Sectionmentioning
confidence: 99%
“…The syntheses of HKP2201 and HKP2202 precursor peptide and radionuclide labeling were performed according to previously published methods. 23 Briefly, CLP002 was synthesized manually using an Fmoc-based solidphase peptide synthesis strategy, as illustrated in Supplementary Figure 1. 1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) was used as a chelator to generate HKP2201 to label 64 Cu and 68 Ga. For the synthesis of HKP2202, a lysine was used as a linker to add the other CLP002.…”
Section: ■ Experimental Sectionmentioning
confidence: 99%
“…Compared with antibody-based imaging agents, small-molecule imaging agents have the advantages of low cost, good tumor penetration, fast tissue uptake and rapid imaging. For example, [ 64 Cu/ 68 Ga]DPA [ 22 ], D-dodecapeptide-based radiotracers, could image PD-L1 expression tumor with high a signal to noise ratio within 60 min. 68 Ga-NOTA-WL12 based on peptide could also acquire tumor images rapidly with reasonable radiation dosimetry [ 23 ].…”
Section: Introductionmentioning
confidence: 99%
“…Such systems have demonstrated efficiencies for differentiating vasculatures and tissues up to week(s) after initial intravenous administration 3 , 4 , 5 , 6 , 7 , 20 . Moreover, there is often interest to enhance the imaging sensitivity, for instance by employing positron emission tomography (PET) 21 , 22 , 23 , 24 , which has led to the increased development of imaging agents for dual modality PET/CT imaging 25 , 26 .…”
Section: Introductionmentioning
confidence: 99%