Whole body radioprotective activity of an acetone–water extract from the seedpod of Nelumbo nucifera Gaertn. seedpod

Lotus Flavonoids and Phenolic Acids: Health Promotion and Safe Consumption Dosages

“…Procyanidins extracted from the lotus seedpod, at a dose of 200 mg/kg bw were effective in reducing radiation‐induced mortality and elevating radiation median lethal dose from 8.9 to 10.5 Gy. They also prevented skin and spleen damage in irradiated mice (Duan et al., ). Furthermore, proanthocyanidins extracted from lotus seedpods also prevented subchronic damage in the spleen and thymus, caused by 4.0 Gy 60 Co‐ã (Duan, Zhang, Tang, Jia, & Xie, ).…”

“…The seeds, in comparison with the other parts of the lotus, do not contain such a high content of flavonoids. However, the seedpod is the only part that is rich in type‐B procyanidin and oligomeric procyanidins (Duan et al., ; Wu et al., , ), also known as condensed tannins (Kyselova, ). The content of procyanidins in the seedpod was 106.22% of that found in grape seeds, indicating a high content (Wu et al., ).…”

“…Long‐term intake of lotus seed tea inhibited protein oxidation of the mice skin with a protein carbonyl value of 17.18 nmol/mg protein (Kim & Moon, ). Meanwhile, lotus leaf extract at a concentration of 100 μg/mL showed significant inhibition of lipid peroxidation (Duan et al., ; Huang et al., ). Lipid peroxidation products including lipid hydroperoxide (LOOH) and conjugated dienes (CD), generated by UVB light oxidative stress, are deleterious for cellular functions (Ramachandran, Prasad, & Karthikeyan, ).…”

Radioprotective activity of neutral polysaccharides isolated from the fruiting bodies of Hohenbuehelia serotina

“…Ionizing radiation could markedly target and attenuate the endogenous antioxidant defense functions, and then destroy the redox balance process. In addition, cells exposed with radiation will lead to the fatal physiologic and morphologic changes in a dose-dependent manner [3]. However, the potential applications of ionizing radiation in medical field are inevitable, so searching for radioprotective agents against radiation damage is extremely necessary and important.…”

Overview of Radiation-protective Agent Research and Prospects for the Future

“…seedpod (LSPCs) for radioprotective activity against whole body gamma irradiation in Swiss albino mice. 28) Pretreatment with LSPCs 200 mg/kg by intragastric for 15 days was found to be the most effective dose in preventing radiation sickness, reducing radiation-induced mortality, increasing mean survival time, and elevating radiation median lethal dose from 8.9 to 10.5 Gy, indicating a dose modifying factor of 1.18. They concluded that LSPCs possess a strong whole body radioprotective activity, and it may be used as a radioprotector.…”