Whole-body Retention, Tissue Distribution and Excretion of Selenium-75 after Oral and Intravenous Administration in Lambs Fed Varying Selenium Intakes

Lopez, Perla L. Vaca; Preston, R. L.; Pfander, W. H.

doi:10.1093/jn/97.1.123

Cited by 42 publications

(19 citation statements)

References 17 publications

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“…Because feed intake was similar, dietary concentration of Se may be used in regression equations instead of calculating daily intake of the element. Results of the present study indicated no effect on feed intake in sheep fed up to 9 mg/kg Se for 30 d. Lopez et al (1969) fed lambs up to 5 mg/kg Se as Na2 SeO3 for 97 d prior to dosing with radioselenium and reported no adverse effect of Se on feed intake orgain. When preruminant calves were fed Se as Na2SeO3 in milk replacer at .2, 1, 3, 5 and 10 mg/kg (in DM) for 42 d, daily feed intake ranged from .83 to .76 kg for calves fed .2 or 10 mg/kg, respectively, and was not different (Jenkins and Hidiroglou, 1986).…”

Section: Resultscontrasting

confidence: 42%

“…In the present experiment, daily Se intake ranged from 3,600 to 10,800 /ag/sheep. Lopez et al (1969) reported that total absorption of ingested Se from the gastrointestinal tract of lambs was a direct function of Se intake, but endogenous secretion into the tract was constant and not related to dietary Se.…”

Section: Slopes From Linear Regression Equations Of Liver Se On Dietamentioning

confidence: 99%

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Effects of Time and Dietary Selenium Concentration as Sodium Selenite on Tissue Selenium Uptake by Sheep

Echevarría

Henry

Ammerman

et al. 1988

Journal of Animal Science

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Thirty crossbred wethers (60 kg avg initial wt) were used to study the time-dose response to dietary Se as sodium selenite (Na2SeO3). Sheep were fed a basal diet (.20 mg/kg Se, M basis) for 10 d; three wethers were killed and tissues were collected for controls. The remaining 27 sheep were assigned randomly to diets supplemented with either 3, 6 or 9 mg/kg Se (as-fed basis) from reagent grade Na2SeO3 and fed for 10, 20 or 30 d. Feed offered was restricted to 1,200 g daily and tap water was available ad libitum. Sheep were stunned and killed by exsanguination and liver, kidney, muscle, heart and spleen were removed and frozen for Se analysis. No toxic effects were noted as expressed by feed intake or hemoglobin concentration. Added dietary Se increased Se linearly (P less than .01) in liver, kidney, and serum. Selenium in liver, kidney and serum also increased (P less than .01) as time advanced. Serum, liver and kidney were more sensitive to dietary Se than were muscle, heart and spleen. Ten days appeared to be an adequate length of time for further Se bioassay studies of this nature. Reagent grade Na2SeO3 was nontoxic when fed to sheep for 30 d at levels up to 90 times the Se requirement.

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Section: Resultscontrasting

confidence: 42%

Section: Slopes From Linear Regression Equations Of Liver Se On Dietamentioning

confidence: 99%

Effects of Time and Dietary Selenium Concentration as Sodium Selenite on Tissue Selenium Uptake by Sheep

Echevarría

Henry

Ammerman

et al. 1988

Journal of Animal Science

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“…The greater uptake of 7 5 Se-selenite by erythrocytes from deficient than supplemented monkeys (Table 3) is consis tent with data for ovine erythrocytes [15,36] where an inverse relationship between Se up take by erythrocytes and Se status was found. This erythrocyte uptake pattern is consistent with work on sheep [37,38], rats [39], and mon keys [40] showing an inverse relationship be tween Se retention and Se status of the animal. The present data indicate that higher primates are similar to other animals in this respect.…”

Section: Selenium Deficiencies In Monkeyssupporting

confidence: 90%

Effects of feeding selenium deficient diets to rhesus monkeys (Macaca Mulatta).

Butler

Whanger

Patton

1988

Journal of the American College of Nutrition

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Pregnant rhesus monkeys (Macaca mulatta) were fed either selenium (Se) deficient or Se supplemented diets with adequate vitamin E. Except for some cardiac irregularities in the first babies born to these females, no physiological disorders due to Se deficiency were seen in a subsequent offspring. Plasma and erythrocyte glutathione peroxidase activities and blood Se levels increased in the Se supplemented monkeys but decreased in the deficient ones. The data indicated that hair Se levels reflect long term exposure to this element. In a very preliminary experiment, evidence was obtained to indicate that dietary protein deficiency along with Se deficiency will generate cardiomyopathic lesions characteristic of Se deficiency. It is hypothesized that, in addition to Se deficiency, another dietary deficiency (or abnormality) is necessary to produce Se deficiency lesions in higher primates. Higher glutathione transferase (or non-Se glutathione peroxidase) activity in tissues of rhesus monkeys may account for this resistance.

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“…Wright and Bell (1963) and Weswig et al (1965) demonstrated that jji vitro uptake of ^^Se by sheep erythrocytes was inversely related to level of dietary selenium. Lopez et al (1969) confirmed that in vivo retention of ^^Se by sheep erythrocytes, whole b!' lod, liver, and kidney was inversely related to dietary selenium inca^^e.…”

Section: General Literature Review Selenium As a Nutrientsupporting

confidence: 54%

Effect of selenium on the digestive enzymes of the porcine pancreas

Adkins

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Whole-body Retention, Tissue Distribution and Excretion of Selenium-75 after Oral and Intravenous Administration in Lambs Fed Varying Selenium Intakes

Cited by 42 publications

References 17 publications

Effects of Time and Dietary Selenium Concentration as Sodium Selenite on Tissue Selenium Uptake by Sheep

Effects of Time and Dietary Selenium Concentration as Sodium Selenite on Tissue Selenium Uptake by Sheep

Effects of feeding selenium deficient diets to rhesus monkeys (Macaca Mulatta).

Effect of selenium on the digestive enzymes of the porcine pancreas

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