Whole-Body<sup>18</sup>F Dopa PET for Detection of Gastrointestinal Carcinoid Tumors

Hoegerle, Stefan; Altehoefer, Carsten; Ghanem, Nadir; Koehler, Gabriele; Waller, Christiane; Scheruebl, Hans; Moser, E.; Nitzsche, Egbert U.

doi:10.1148/radiology.220.2.r01au25373

Cited by 257 publications

(117 citation statements)

References 27 publications

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“…Thus, a serotonin precursor 11C-5 hydroxy tryptophan was developed as a tracer for PET-scanning, which can be concentrated within carcinoid tumors [13] . Findings using this application are encouraging, allowing the identification of the primary tumor in 84% of cases [14,15] . Primary carcinoid tumors and distant metastasis in patients affected by neuroendocrine tumors are better detected by otreoscan scintigraphy compared to the CT scan and the MRI [16] .…”

Section: Discussionmentioning

confidence: 86%

Primary hepatic carcinoid: A case report and literature review

Fenoglio¹,

Severini²,

Ferrigno³

et al. 2009

WJG

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Carcinoids are tumors derived from neuroendocrine cells and often produce functional peptide hormones. Approximately 54.5% arise in the gastrointestinal tract and frequently metastasize to the liver. Primary hepatic carcinoid tumors (PHCT) are extremely rare; only 95 cases have been reported. A 65-year-old man came to our attention due to occasional ultrasound findings in absence of clinical manifestations. His previous medical history, since 2003, included an echotomography of the dishomogeneous parenchymal area but no focal lesions. A computed tomography s c a n p e r fo r m e d i n 2 0 0 5 s h o w e d an enhanced pseudonodular-like lesion of about 2 cm. Cholangiomagnetic resonance imaging identified the lesion as a possible cholangiocarcinoma. No positive findings were obtained with positron emission tomography. Histology suggested a secondary localization in the liver caused by a low-grade malignant neuroendocrine tumor. Immunohistochemistry was positive for anti chromogranin antibodies, Ki67 antibodies and synaptophysin. Octreoscan scintigraphy indicated intense activity in the lesion. Endoscopic investigations were performed to exclude the presence of extrahepatic neoplasms. Diagnosis of PHCT was established. The patient underwent left hepatectomy, followed by hormone therapy with sandostatine LAR. Two months after surgery he had a lymph nodal relapse along the celiac trunk and caudate lobe, which was histologically confirmed. The postoperative clinical course was uneventful, with a negative follow-up for hematochemical, clinical and radiological investigations at 18 mo post-surgery. Diagnosis of PHCT is based principally on the histopathological confirmation of a carcinoid tumor and the exclusion of a non-hepatic primary tumor. Surgical resection is the recommended primary treatment for PHCT. Recurrence rate and survival rate in patients treated with resection were 18% and 74%, respectively.

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Section: Discussionmentioning

confidence: 86%

Primary hepatic carcinoid: A case report and literature review

Fenoglio¹,

Severini²,

Ferrigno³

et al. 2009

WJG

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“…Therefore, several tracers directed toward the specific characteristics of carcinoid tumors, for example, 6-[ 18 F]fluorodopamine ( 18 F-dopa) and 11 C-labeled 5-HTP, were developed for PET imaging in these tumors [45,46]. Although the availability of PET scanning for the clinical diagnosis of carcinoid tumors is still limited, promising results have been described in diagnosing small lesions and lymph node metastases with a sensitivity of up to 65% for 18 F-dopa PET [47].…”

Section: F-labeled Fluorodeoxyglucose ( 18 Fdg) Is Widely Used As a Pmentioning

confidence: 99%

Metastatic Carcinoid Tumors: A Clinical Review

2005

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Carcinoid tumors are neuroendocrine tumors derived from enterochromaffin cells, which are widely distributed in the body. They can originate from any location in the body, but they are traditionally described as originating from the foregut, midgut, and hindgut. Although the overall incidence of carcinoid tumors appears to have increased in the past decades, the prognosis for patients with metastatic carcinoid tumors has improved during the last decade. Due to longer survival times, complications, such as carcinoid heart disease, and new metastatic patterns, like skin and bone metastases, may become more important features of carcinoid disease. Therapy focused on these complications should be part of the management. Combining new diagnostic and treatment modalities in metastatic carcinoid patients may result in better quality of life and longer survival times. The increasing number of therapeutic options and diagnostic procedures requires a multidisciplinary approach, with decisions made in multidisciplinary meetings focused on "tailor-made" therapy based on patients' specific conditions. Because carcinoid tumors are uncommon, effort should be made to treat these patients in specialized centers and for these centers to join together in multicenter studies. The Oncologist 2005;10:123-131The Oncologist 2005;10:123-131 www.TheOncologist.com

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“…CT scanning of the abdomen and thorax as well as somatostatin receptor scintigraphy are the major imaging modalities used to establish tumor staging and localization initially [13,14,40,41] . 68-Gallium-DOTATOC-PET/CT is a new, very sensitive method for visualizing (metastatic) intestinal NETs [42][43][44] ; however, this costly technique is not available everywhere. Due to frequent carcinoid heart disease (in up to 30%-60% of patients with carcinoid syndrome), every patient with carcinoid syndrome or with elevated urinary 5-HIAA levels should be echocardiographed [13] .…”

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confidence: 99%

Neuroendocrine tumors of the small bowels are on the rise: Early aspects and management

Scherübl

Jensen²,

Cadiot³

et al. 2010

WJGE

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Neuroendocrine tumors of the small bowel are on the rise. In the US they have increased by 300%-500% in the last 35 years. At the same time their prognosis is much improved. Today, most neuroendocrine tumors (NETs) of the duodenum are detected "incidentally" and therefore recognized at an early stage. Duodenal NETs which are well differentiated, not larger than 10 mm and limited to the mucosa/submucosa can be endoscopically resected. The management of duodenal NETs ranging between 10 and 20 mm needs an interdisciplinary discussion. Endoscopic ultrasound is the method of choice to determine tumor size and depth of infiltration. Surgery is recommended for welldifferentiated duodenal NET tumors greater than 20 mm, for localized sporadic gastrinomas (of any size) and for localized poorly differentiated NE cancers. Surgery is recommended for any ileal NET. Advanced ileal NETs with a carcinoid syndrome are treated with longacting somatostatin analogs. This treatment significantly improves (progression-free) survival in patients with metastatic NETs of the ileum. For optimal NET management, tumor biology, type, localization and stage of the neoplasm, as well as the patient's individual circumstances have to be taken into account.

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Whole-Body¹⁸F Dopa PET for Detection of Gastrointestinal Carcinoid Tumors

Abstract: 18F dopa PET is a promising procedure and useful supplement to morphologic methods in diagnostic imaging of gastrointestinal carcinoid tumors.

Cited by 257 publications

References 27 publications

Primary hepatic carcinoid: A case report and literature review

Primary hepatic carcinoid: A case report and literature review

Metastatic Carcinoid Tumors: A Clinical Review

Neuroendocrine tumors of the small bowels are on the rise: Early aspects and management

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Whole-Body18F Dopa PET for Detection of Gastrointestinal Carcinoid Tumors

Abstract: 18F dopa PET is a promising procedure and useful supplement to morphologic methods in diagnostic imaging of gastrointestinal carcinoid tumors.

Cited by 257 publications

References 27 publications

Primary hepatic carcinoid: A case report and literature review

Primary hepatic carcinoid: A case report and literature review

Metastatic Carcinoid Tumors: A Clinical Review

Neuroendocrine tumors of the small bowels are on the rise: Early aspects and management

Contact Info

Product

Resources

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Whole-Body¹⁸F Dopa PET for Detection of Gastrointestinal Carcinoid Tumors