Whole-body vibration of mice induces articular cartilage degeneration with minimal changes in subchondral bone

McCann, Matthew R.; Yeung, Cynthia; Pest, M.A.; Ratneswaran, A.; Pollmann, Steven I.; Holdsworth, David W.; Beier, Frank; Dixon, S. Jeffrey; Séguin, Cheryle A.

doi:10.1016/j.joca.2016.11.001

Cited by 20 publications

(18 citation statements)

References 52 publications

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“…The spatial and temporal associations between autophagy, cell density, and degeneration in cartilage with similar changes in meniscus require further experiments to establish cause and effect. Sample sizes for individual groups were small but within the range commonly reported for mouse studies of knee degeneration and osteoarthritis 44–50 .…”

Section: Discussionmentioning

confidence: 88%

Compromised autophagy precedes meniscus degeneration and cartilage damage in mice

Meckes

Caramés

Olmer

et al. 2017

Osteoarthritis and Cartilage

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Objective Autophagy is a cellular homeostasis mechanism that facilitates normal cell function and survival. Objectives of this study were to determine associations between autophagic responses with meniscus injury, joint aging, and osteoarthritis (OA), and to establish the temporal relationship with structural changes in menisci and cartilage. Methods Constitutive activation of autophagy during aging was measured in GFP-LC3 transgenic reporter mice between 6 and 30 months. Menisus injury was created by surgically destabilizing the medial meniscus (DMM) to induce posttraumatic OA in C57BL/6J mice. Levels of autophagy proteins and activation were analyzed by confocal microscopy and immunohistochemistry. Associated histopathological changes, such as cellularity, matrix staining, and structural damage, were graded in the meniscus and compared to changes in articular cartilage. Results In C57BL/6J mice, basal autophagy was lower in the meniscus than in articular cartilage. With increasing age, expression of the autophagy proteins ATG5 and LC3 was signficantly reduced by 24 months. Age-related changes included abnormal Safranin-O staining and reduced cellularity, which preceded structural damage in the meniscus and articular cartilage. In mice with DMM, autophagy was induced in the meniscus while it was suppressed in cartilage. Articular cartilage exhibited the most profound changes in autophagy and structure that preceded meniscus degeneration. Systemic administration of rapamycin to mice with DMM induced autophagy activation in cartilage and reduced degenerative changes in both meniscus and cartilage. Conclusion Autophagy is significantly affected in the meniscus during aging and injury and precedes structural damage. Maintenance of autophagic activity appears critical for meniscus and cartilage integrity.

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Section: Discussionmentioning

confidence: 88%

Compromised autophagy precedes meniscus degeneration and cartilage damage in mice

Meckes

Caramés

Olmer

et al. 2017

Osteoarthritis and Cartilage

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“…Although loss of articular cartilage is the hallmark pathological feature in OA, disease progression involves early subchondral trabecular bone remodeling resulting in decreased trabecular bone mass and formation of osteophytes at the joint margins [McCann et al, 2017]. Changes in bone remodeling are frequently present early in the OA process [Saberi Hosnijeh et al, 2018].…”

Section: Discussionmentioning

confidence: 99%

“…Clinical studies have suggested that WBV can relieve self‐perception of pain, improve muscle performance, balance, and gait quality, build muscle strength, decrease inflammatory markers, and minimize or slow the progression of disease in KOA [Lai et al, 2017; Simão et al, 2019]. However, a previous study found that meniscal tears and focal articular cartilage damage were induced by WBV with 45 Hz, 0.3 g peak acceleration between 4‐ and 8‐week exposures [McCann et al, 2017]. While these data suggest that excessive or insufficient mechanical loading may be deleterious to cartilage, there appears to be a “window” where some degree of loading is beneficial to the tissue [Pamon et al, 2018].…”

Section: Introductionmentioning

confidence: 99%

Pulsed Electromagnetic Field Versus Whole Body Vibration on Cartilage and Subchondral Trabecular Bone in Mice With Knee Osteoarthritis

Guo

Yang

et al. 2020

Bioelectromagnetics

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Pulsed electromagnetic field (PEMF) and whole body vibration (WBV) interventions are expected to be important strategies for management of osteoarthritis (OA). The aim of the study was to investigate the comparative effectiveness of PEMF versus WBV on cartilage and subchondral trabecular bone in mice with knee OA (KOA) induced by surgical destabilization of the medial meniscus (DMM). Forty 12-week-old male C57/BL mice were randomly divided into four groups (n = 10): Control, OA, PEMF, and WBV. OA was induced (OA, PEMF, and WBV groups) by surgical DMM of right knee joint. Mice in PEMF group received 1 h/day PEMF exposure with 75 Hz, 1.6 mT for 4 weeks, and the WBV group was exposed to WBV for 20 min/day with 5 Hz, 4 mm, 0.3 g peak acceleration for 4 weeks. Microcomputed tomography (micro-CT), histology, and immunohistochemistry analyses were performed to evaluate the changes in cartilage and microstructure of trabecular bone. The bone volume fraction (BV/TV), trabecular thickness (Tb.Th), and trabecular number (Tb.N) increased, and bone surface/bone volume (BS/BV) decreased by micro-CT analysis in PEMF and WBV groups. The Osteoarthritis Research Society International (OARSI) scores in PEMF and WBV groups were significantly lower than in the OA group. Immunohistochemical results showed that PEMF and WBV promoted expressions of Aggrecan, and inhibited expressions of IL-1β, ADAMTS4, and MMP13. Superior results are seen in PEMF group compared with WBV group. Both PEMF and WBV were effective, could delay cartilage degeneration and preserve subchondral trabecular bone microarchitecture, and PEMF was found to be superior to WBV. Bioelectromagnetics. 2020;41:298-307.

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“…At any rate, from the above reported scientific data it is highlighted that low intensities and low amplitudes are more suitable for individuals with a higher risk of fractures such as patients with osteoporosis [43]. Physical activity could also be used as therapeutic action for cartilage diseases such as osteoarthritis [44,45]. Physical activity should have the primary goal of preventing overloading and misuse of the joints.…”

Section: Adaptive Responses Of Bone and Cartilage To Vibration Exposurementioning

confidence: 99%

The Use of Vibration as Physical Exercise and Therapy

Musumeci

2017

JFMK

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Abstract:Musculoskeletal vibration stimulation is the topic chosen for this review. The aim is to discuss this interesting, but poorly analyzed topic in the current literature in order to explain and help readers to better understand the effects of vibration used as an exercise intervention and therapy for muscle, bone, and cartilage tissues. The use of vibration stimulation for enhancing athletic performance and therapeutic use is considered an important matter of medical biology that has developed in the last three decades. Current evidence suggests that vibration is effective in enhancing musculoskeletal strength and power capacity and improving physical conditions in patients with related disorders such as osteoporosis and osteoarthritis, although the mechanisms mediating these effects are still not well known.

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Whole-body vibration of mice induces articular cartilage degeneration with minimal changes in subchondral bone

Cited by 20 publications

References 52 publications

Compromised autophagy precedes meniscus degeneration and cartilage damage in mice

Compromised autophagy precedes meniscus degeneration and cartilage damage in mice

Pulsed Electromagnetic Field Versus Whole Body Vibration on Cartilage and Subchondral Trabecular Bone in Mice With Knee Osteoarthritis

The Use of Vibration as Physical Exercise and Therapy

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