Whole-body vibration slows the acquisition of fat in mature female rats

Abstract

Objective: To evaluate the effects of whole-body vibration on fat, bone, leptin and muscle mass. Methods/Design: Thirty 7-month-old female 344 Fischer rats were randomized by weight into three groups (baseline, vibration or control; n ¼ 8-10 per group). Rats in the vibration group were placed inside individual compartments attached to a Pneu-Vibe vibration platform (Pneumex, Sandpoint, ID, USA) and vibrated at 30-50 Hz (6 mm peak to peak) for 30 min per day, 5 days per week, for 12 weeks. The vibration intervention consisted of six 5-min cycles with a 1-min break between cycles. Results: There were significant body composition differences between the whole-body vibration and the control group. The whole-body vibration group weighed approximately 10% less (mean ± s.d.; 207 ± 10 vs 222 ± 15 g, Po0.03) and had less body fat (20.8 ± 3.8 vs 26.8 ± 5.9 g, Po0.05), a lower percentage of body fat (10.2 ± 1.7 vs 12 ± 2.0%, Po0.05), and lower serum leptin levels (1.06 ± 0.45 vs 2.27 ± 0.57 ng ml À1 , Po0.01) than the age-matched controls. No differences were observed for total lean mass, bone mineral content (BMC), bone mineral density (BMD), insulin-like growth factor-I (IGF-I) or soleus (SOL) and extensor digitorum longus (EDL) mass or function. Regional high-resolution dual-energy X-ray absoptiometry scans of the lumbar spine (L1-4) revealed that the whole-body vibration group had significantly greater BMC (0.33 ± 0.05 vs 0.26 ± 0.03 g, Po0.01) and BMD (0.21±0.01 vs 0.19±0.01 g cm À2 , Po0.01) than the control group. No differences between the groups were observed in the amount of food consumed. Conclusion: These findings show that whole-body vibration reduced body fat accumulation and serum leptin without affecting whole body BMC, BMD or lean mass. However, the increase in vertebral BMC and BMD suggests that vibration may have resulted in local increases in bone mass and density. Also, whole-body vibration did not affect muscle function or food consumption.

Effect of Combination Therapy of Fatty Acids, Calcium, Vitamin D and Boron with Regular Physical Activity on Cardiovascular Risk Factors in Rat

“…Although the mechanism responsible for the increased body weight was not studied, it is assumed that the observed body weight gain may be the result of higher muscle mass and bone mass and/or the result of higher blood fl ow leading to the alteration on the peripheral vascular and tissue perfusion. Maddalozzo et al 2008 reported that mature female vibrated rats weighed 10 less, with less body fat and serum leptin concentrations 8 . Interestingly, in the AF group Gr.…”

“…Recently, whole body vibration has been proposed as a potential alternative, or adjuvant, to exercise 8 25 , reducing the risk of bone fracture more than walking 26 , increasing the serum levels of testosterone and growth hormone 27 , and representing no stressful stimulus for the neuroendocrine and neuromuscular systems 27,28 . Further, it would be well-advised to determine the infl uence of WBV on CVD risk factors.…”

“…The findings suggest that WBV training improved isometric and dynamic muscle, muscle strength and cardiorespiratory fi tness 2,6,7 , and was reported to reduce body fat accumulation and serum leptin concentration 8 .…”

Rare adipose disorders (RADs) masquerading as obesity

“…Supporting the use of WBV as exercise in DD, WBV slowed the acquisition of fat in female rats [242] and improved pain and fatigue in women with fibromyalgia [243] .…”

Whole-body vibration and weight loss: truth or consequence?

“…Maddalozzo et al 1 recently reported that 12 weeks of wholebody vibration (WBV) reduced body fat accumulation and serum leptin levels in rats. Taken at face value, these results are potentially important to the treatment of obesity.…”