Whole-Body Vibration Training Effect on Physical Performance and Obesity in Mice

Huang, Chi‐Chang; Tseng, Tzu‐Ling; Huang, Wen-Ching; Chung, Y.; Chuang, Hsiao-Li; Wu, June H.

doi:10.7150/ijms.9975

Cited by 43 publications

(43 citation statements)

References 35 publications

(42 reference statements)

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“…Moreover, WBV has been confirmed as potential alternative exercise training method to increase physical fitness adherence in non-obese [11] and obese adults [10]. As previously reported, WBV might have positive acute and chronic effects in both obese mice [30] and humans [28,10]. Huang et al [30] showed that WBV could improve exercise performance and prevent fat accumulation in obese mice suggesting a possible clinical use of WBV in the prevention and treatment of obesity.…”

Section: Salivary Cortisol Levelsmentioning

confidence: 87%

Effects of Acute Whole-Body Vibration Practice on Maximal Fat Oxidation in Adult Obese Males: A Pilot Study

et al. 2020

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Objective: Whole-body vibration (WBV) training has been established as a useful method to improve physical fitness in obese individuals. However, the effects of WBV exercise on maximal fat oxidation (MFO) have not been examined in obese subjects yet. Method: MFO was evaluated during a cardiopulmonary exercise test (CPET) on a treadmill in 12 adult obese males (BMI = 34.9 ± 3.3 kg/m 2 ) after three different warm-up conditions: static half squat plus WBV (HSV), static half squat without WBV (HSWV), and rest (REST). Cortisol levels were evaluated before and after the warm-up, and 1 min (T1), 10 min (T10), and 30 min (T30) of the recovery phase. Results: MFO was significantly higher in HSV (p = 0.013; 569.4 ± 117.9 mg/min) and HSWV (p = 0.033; 563.8 ± 142.9 mg/min) than REST (445.5 ± 117.9 mg/min). Cortisol concentrations at T1 were significantly higher in HSV (p = 0.023) and HSWV (p = 0.015) than REST. Moreover, cortisol concentrations were significantly lower at T30 than T1 in HSWV (p = 0.04). No differences were found between T30 and T1 in HSV. Conclusions: Active warm-up increases MFO; however, vibration stimulus during half squatting does not increase MFO during a CPET in obese subjects. The lack of significant differences of cortisol concentrations in HSV during the recovery phase might suggest a long-term effect of WBV on the endocrine system. ± 2.2 ng/mL) and no significant time-dependent reduction was found during recovery phase. Cortisol concentrations were significantly lower at PRE than T1 (p = 0.028), T10 (p = 0.003), and T30 (p = 0.008). Moreover, cortisol concentrations at POST were significantly lower than T1 (p = 0.003) and T10 (p = 0.006).In HSWV, cortisol levels were significantly higher at POST (0.981 ± 0.7 ng/mL, p = 0.019) and T1 (1.3 ± 0.9 ng/mL; p = 0.023) compared to PRE. Thereafter, a significant, time-dependent reduction was found from T10 to T30 when compared to the T1 point (T10 = 0.992 ± 0.8 ng/ mL; p = 0.004 and T30 = 0.743 ± 0.5 ng/mL; p = 0.003). Moreover, cortisol levels were significantly lower at T30 than T10 (p = 0.002), and no statistically significant differences were found among the other time points.

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Section: Salivary Cortisol Levelsmentioning

confidence: 87%

Effects of Acute Whole-Body Vibration Practice on Maximal Fat Oxidation in Adult Obese Males: A Pilot Study

et al. 2020

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“…A recent study also with C57BL/6 mouse models pointed that MV can positively affect the body weight of animals (Huang et al. ).…”

Section: Discussionmentioning

confidence: 96%

“…One of the earliest reports of MV influence on obesity in a high-fat diet-induced obesity model (C57BL/6 mice) demonstrated that 12 weeks of treatment was able to reduce subcutaneous and visceral fat in the obese animals concurrent with increased bone marrow MSCs with decreased adipogenic differentiation capability (Luu et al 2009). A recent study also with C57BL/6 mouse models pointed that MV can positively affect the body weight of animals (Huang et al 2014).…”

Section: Discussionmentioning

confidence: 99%

Estrogen therapy associated with mechanical vibration improves bone microarchitecture and density in osteopenic female mice

et al. 2018

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We investigated the effects of estrogen therapy (ET) associated with low‐intensity and high‐frequency mechanical vibration (MV) on bone tissue in osteopenic female mice. Fifty 3‐month‐old female Swiss mice were ovariectomized (OVX) or sham‐operated, and distributed after 4 months into the following groups, with 10 animals per group: Sham; Control, OVX + vehicle solution; MV, OVX + MV; ET, OVX + 17β‐estradiol; and MV + ET, OVX + MV and 17β‐estradiol. Both vehicle solution and 17β‐estradiol (10 μg kg−1 day−1) were injected subcutaneously 7 days per week, and vibration (0.6 g, 60 Hz) was delivered 30 min per day, 5 days per week. Bone mineral density (BMD) and body composition were evaluated by densitometry at baseline and after 60 days of treatment when the animals were euthanized, and their femurs underwent histomorphometric and histochemical analyses. The Control group showed increased weight and fat percentage, while the ET and MV + ET groups showed increased lean mass but decreased fat percentage. At the end of the treatment period, the BMD decreased in Control, remained constant in Sham and MV, and increased in ET and MV + ET. The MV + ET group showed the greatest bone volume compared with Sham (129%), Control (350%), MV (304%) and ET (14%). No differences occurred in cortical thickness. The Control group showed the highest content of mature collagen fibers, while the MV + ET group showed the highest content of immature collagen fibers. In conclusion, ET plus MV was effective in improving bone quality in osteopenic female mice, and this improvement is associated with specific changes in trabecular but not cortical bone.

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“…175 Vibration treatment was also tested and proved positive in a more severe obesity model. Application of vibration (0.5 × g , 45 Hz, 60 min/day) for 12 weeks in female db/db mice ameliorated insulin resistance, showing the potential for the treatment of type 2 diabetes.…”

Section: Combating Obesity With Mechanical Signalsmentioning

confidence: 99%

“…70,174 Whole-body vibration of different intensity but relatively low magnitude (0.13-0.68 × g, 5.6-13 Hz) was shown to improve exercise performance and reduce fatigue while also preventing fat accumulation in obese mice. 175 Vibration treatment was also tested and proved positive in a more severe obesity model. Application of vibration (0.5 × g, 45 Hz, 60 min/day) for 12 weeks in female db/db mice ameliorated insulin resistance, showing the potential for the treatment of type 2 diabetes.…”

Section: In Models Of Obesitymentioning

confidence: 99%

Mechanical signals protect stem cell lineage selection, preserving the bone and muscle phenotypes in obesity

Frechette

Krishnamoorthy

Pamon

et al. 2017

Annals of the New York Academy of Sciences

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The incidence of obesity is rapidly rising, increasing morbidity and mortality rates worldwide. Associated comorbidities include type 2 diabetes, heart disease, fatty liver disease, and cancer. The impact of excess fat on musculoskeletal health is still unclear, although it is associated with increased fracture risk and a decline in muscular function. The complexity of obesity makes understanding the etiology of bone and muscle abnormalities difficult. Exercise is an effective and commonly prescribed non-pharmacological treatment option, but it can be difficult or unsafe for the frail, elderly, and morbidly obese. Exercise alternatives, such as low-intensity vibration (LIV), have potential for improving musculoskeletal health, particularly in conditions with excess fat. LIV has been shown to influence bone marrow mesenchymal stem cell differentiation toward higher-order tissues (i.e., bone) and away from fat. While the exact mechanisms are not fully understood, recent studies utilizing LIV both at the bench and in the clinic have demonstrated its efficacy. Here, we discuss the current literature investigating the effects of obesity on bone, muscle, and bone marrow and how exercise and LIV can be used as effective treatments for combating the negative effects in the presence of excess fat.

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Whole-Body Vibration Training Effect on Physical Performance and Obesity in Mice

Cited by 43 publications

References 35 publications

Effects of Acute Whole-Body Vibration Practice on Maximal Fat Oxidation in Adult Obese Males: A Pilot Study

Effects of Acute Whole-Body Vibration Practice on Maximal Fat Oxidation in Adult Obese Males: A Pilot Study

Estrogen therapy associated with mechanical vibration improves bone microarchitecture and density in osteopenic female mice

Mechanical signals protect stem cell lineage selection, preserving the bone and muscle phenotypes in obesity

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