Whole-Bone Toughness Is Linked to Canal and Osteocyte Lacunae Deficits in the ZDSD Type 2 Diabetic Rat Model

Woolley, William; Obata, Yoshihiro; Martin, Kaitlynn; Acevedo, Claire

doi:10.1007/s11837-023-05882-8

JOM

2023

DOI: 10.1007/s11837-023-05882-8

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Whole-Bone Toughness Is Linked to Canal and Osteocyte Lacunae Deficits in the ZDSD Type 2 Diabetic Rat Model

William Woolley

Yoshihiro Obata

Kaitlynn Martin

et al.

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2024

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Cited by 2 publications

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Glycemic Marker Correlation with Collagen Denaturation and Non-Enzymatic Collagen Cross-Linking in Age-Associated Bone Resistance

Rosenberg,

Sundaresh,

Gililland

et al. 2024

JOM

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The primary clinical indicator of fracture risk among the elderly is low bone mass, yet it accounts for less than half of fractures in individuals over 50 years. Age is recognized to influence bone quality, affecting bone structure and properties. Previous research indicates that age diminishes tissue plasticity and toughness conferred by collagen, suggesting that age-related changes in the collagen environment may contribute to bone fragility. This study explores the relationship between age-related collagen impairment, specifically the accumulation of non-enzymatic collagen cross-linking and molecular collagen denaturation, and bone toughness in middle-aged and older patients (postmenopausal 50–70 years old and senile osteoporosis age > 70 years old). Additionally, it examines the influence of blood glucose and HbA1c levels, as well as body mass index (BMI), on these factors. Despite not finding any differences in fracture toughness between groups, we found a significant correlation between hemoglobin A1c and collagen integrity (collagen denaturation and non-enzymatic cross-linking).

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Glycemic Marker Correlation with Collagen Denaturation and Non-Enzymatic Collagen Cross-Linking in Age-Associated Bone Resistance

Rosenberg,

Sundaresh,

Gililland

et al. 2024

JOM

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Quantitative ultrasound imaging reveals distinct fracture-associated differences in tibial intracortical pore morphology and viscoelastic properties in aged individuals with and without diabetes mellitus – an exploratory study

Dehnen,

Galindo,

Hoff

et al. 2024

Front. Endocrinol.

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IntroductionDiabetes mellitus (DM) is a chronic metabolic disorder that increases fragility fracture risk. Conventional DXA-based areal bone mineral density (aBMD) assessments often underestimate this risk. Cortical Backscatter (CortBS) ultrasound, a radiation-free technique, non-invasively analyzes cortical bone’s viscoelastic and microstructural properties. This study aimed to evaluate CortBS’s discriminative performance in DM patients compared to DXA and characterize changes in cortical bone microstructure in Type 1 and Type 2 DM (T1DM, T2DM) patients.MethodsThis in-vivo study included 89 DM patients (T1DM = 39, T2DM = 48) and 76 age- and sex-matched controls. DXA measured aBMD, while CortBS measurements were taken at the anteromedial tibia using a medical ultrasound scanner with custom software. Multivariate analysis of variance assessed the impact of DM type on CortBS and DXA measurement results. Partial least squares discriminant analyses with cross-validation were used to compare the discrimination performance for vertebral, non-vertebral, and any fragility fractures, adjusting for gender, age, and anthropometric parameters (weight, height, BMI).ResultsFractures occurred in 8/23 T1DM, 17/18 T2DM, and 16/55 controls. DXA parameters were reduced in fracture patients, with significant diabetes impact. T2DM was associated with altered CortBS parameters, reduced scatterer density, and larger pores. CortBS outperformed DXA in discriminating fracture risk (0.61 ≤ AUC(DXA) ≤ 0.63, 0.68 ≤ AUC(CortBS) ≤ 0.69).ConclusionsBoth T1DM and T2DM showed altered bone metabolism, with T2DM linked to impaired tissue formation. CortBS provides insights into pathophysiological changes in diabetic bone and provided superior fracture risk assessment in DM patients compared to DXA.

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Whole-Bone Toughness Is Linked to Canal and Osteocyte Lacunae Deficits in the ZDSD Type 2 Diabetic Rat Model

Cited by 2 publications

References 84 publications

Glycemic Marker Correlation with Collagen Denaturation and Non-Enzymatic Collagen Cross-Linking in Age-Associated Bone Resistance

Glycemic Marker Correlation with Collagen Denaturation and Non-Enzymatic Collagen Cross-Linking in Age-Associated Bone Resistance

Quantitative ultrasound imaging reveals distinct fracture-associated differences in tibial intracortical pore morphology and viscoelastic properties in aged individuals with and without diabetes mellitus – an exploratory study

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