Whole-Cell Biosensors for Qualitative and Quantitative Analysis of Quorum Sensing Signal Molecules and the Investigation of Quorum Quenching Agents

Mellini, Marta; Letizia, Morgana; Leoni, Livia; Rampioni, Giordano

doi:10.1007/978-1-0716-3473-8_5

Cited by 3 publications

(1 citation statement)

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“…Apparently, an effective syn-com may harbour QS-active bacteria, which provide the applied synthetic community a dynamic character to modulate the rhizosphere microbiome and stimulate the plant host to develop abiotic and biotic resistance properties (Andres-Barrao et al 2017 ). Further progress in revealing the involvement of QS-regulation in plant as well as in human health is still dependent on further optimization of the sensitivity and specificity of QS-signal analytical approaches (Mellini et al 2024 ). Concerning the severe problem of rapid spreading of chronic infections in humans because of the immense dangerous threat by multiresistant pathogens, the application of QS-affecting approaches, which target virulence acquisition processes of pathogens promised to avoid the selection of antibiotic resistances, because growth of pathogens is not directly targeted.…”

Section: Discussionmentioning

confidence: 99%

Quorum sensing-related activities of beneficial and pathogenic bacteria have important implications for plant and human health

Hartmann,

Binder,

Rothballer

2024

FEMS Microbiology Ecology

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Eukaryotic organisms co-evolved with microbes from the environment forming holobiotic meta-genomic units. Members of host-associated microbiomes have commensalic, benefical / symbiotic or pathogenic phenotypes. More than 100 years ago, Lorenz Hiltner, pioneer of soil microbiology, introduced the term “Rhizosphere“ to characterize the observation that a high density of saprophytic, beneficial and pathogenic microbes are attracted by root exudates. The balance between these types of microbes decide about the health of the host. Nowadays we know, that for the interaction of microbes with all eukaryotic hosts similar principles and processes of cooperative and competitive functions are in action. Small diffusible molecules like (phyto)hormones, volatiles and quorum sensing signals are examples for mediators of interspecies and cross-kingdom interactions. Quorum sensing (QS) of bacteria is mediated by different auto-inducible metabolites in a density dependent manner. In this perspective publication, the role of QS-related activities for the health of hosts will be discussed focussing mostly on N-acyl-homoserine lactones (AHL). It is also considered that in some cases very close phylogenetic relations exist between plant beneficial and opportunistic human pathogenic bacteria. Based on a genome and system-targeted new understanding, sociomicrobiological solutions are possible for the biocontrol of diseases and the health improvement of eukaryotic hosts.

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Section: Discussionmentioning

confidence: 99%