2020
DOI: 10.3390/pr8080969
|View full text |Cite
|
Sign up to set email alerts
|

Whole-Cell Biotransformation of 1,12-Dodecanedioic Acid from Coconut Milk Factory Wastewater by Recombinant CYP52A17SS Expressing Saccharomyces cerevisiae

Abstract: Biotransformation of fatty acids from renewable wastewater as feedstock to value-added chemicals is a fascinating commercial opportunity. α,ω-dicarboxylic acids (DCAs) are building blocks in many industries, such as polymers, cosmetic intermediates, and pharmaceuticals, and can be obtained by chemical synthesis under extreme conditions. However, biological synthesis can replace the traditional chemical synthesis using cytochrome P450 enzymes to oxidize fatty acids to DCAs. Saccharomyces cerevisiae BY(2R)/pYeDP… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

0
6
0

Year Published

2022
2022
2024
2024

Publication Types

Select...
5

Relationship

0
5

Authors

Journals

citations
Cited by 5 publications
(6 citation statements)
references
References 32 publications
0
6
0
Order By: Relevance
“…Because the main fatty acid present in coconut milk factory wastewater is lauric acid (approximately 45%-53%), this can be converted to 12-hydroxydodecanoic acid (12-HDDA) and 1,12-DDA via omega oxidation (ω-oxidation) involving the hydroxylation of the terminal alkyl carbon of a fatty acids to an alcohol, followed by further oxidation to a dicarboxylic acid. At the optimum operation condition (30 • C and pH 5), a yield of 60 and 38 µg L −1 was achieved for 12-HDDA and 1,12-DDA, respectively, using coconut milk factory wastewater with 10 g L −1 yeast extract and 20 g L −1 peptone [75]. Moreover, sugar-containing waste/wastewater would be even more economical as this might not require extra glucose for cell growth.…”
Section: Long-chain Dicarboxylic Acids From Wastewatermentioning
confidence: 99%
See 2 more Smart Citations
“…Because the main fatty acid present in coconut milk factory wastewater is lauric acid (approximately 45%-53%), this can be converted to 12-hydroxydodecanoic acid (12-HDDA) and 1,12-DDA via omega oxidation (ω-oxidation) involving the hydroxylation of the terminal alkyl carbon of a fatty acids to an alcohol, followed by further oxidation to a dicarboxylic acid. At the optimum operation condition (30 • C and pH 5), a yield of 60 and 38 µg L −1 was achieved for 12-HDDA and 1,12-DDA, respectively, using coconut milk factory wastewater with 10 g L −1 yeast extract and 20 g L −1 peptone [75]. Moreover, sugar-containing waste/wastewater would be even more economical as this might not require extra glucose for cell growth.…”
Section: Long-chain Dicarboxylic Acids From Wastewatermentioning
confidence: 99%
“…Next to membrane-based liquid-liquid extraction, the application of AEX resin to adsorb the MCCAs from fermentation broth has also been investigated [61,74,75]. A preliminary study by Rebecchi et al [59] in batch scale illustrated the highest affinity and selectivity of Amberlyst A21 (a tertiary amine AEX resin) toward MCCAs in the complex carboxylic acids mixture obtained by acidogenic digestion of grape pomaces.…”
Section: Adsorption Using Anion Exchange Resinsmentioning
confidence: 99%
See 1 more Smart Citation
“…Therefore, there is an urgent need to develop harmless, resource-based, and large-scale treatment technologies to simplify the existing pretreatment process and achieve the high-value utilization of food waste. This can not only improve the use of this “waste” resource and overcome resource shortage but also facilitate environmental restoration. …”
Section: Prospecting the Synthesis Of Dicarboxylic Acids From The Per...mentioning
confidence: 99%
“…α,β‐Dicarboxylic acids (DCAs) are building blocks in many industries, such as polymers, cosmetic intermediates, and pharmaceuticals. Saccharomyces cerevisiae BY(2R)/pYeDP60‐CYP52A17SS (BCM), a transgenic strain expressing the galactose‐inducible CYP52A17SS cytochrome P450 enzyme, was able to grow in a coconut milk factory wastewater (CCW) medium and produced 12‐hydroxydodecanoic acid (HDDA) and 1,12‐dodecanedioic acid (DDA) (Buathong et al, 2020).…”
Section: Application In Chemical Industrymentioning
confidence: 99%