Whole exome sequencing identifies genetic variants in Chinese Han pregnant women with venous thromboembolism

Shen, Yuxia; Zhang, Yan; Xiong, Ying; Zhang, Zhiping; Zhang, Baohua; Li, Aihong; Zhang, Zhaofeng; Ding, Jing; Du, Jing; Che, Yan

doi:10.1016/j.thromres.2022.01.015

Cited by 2 publications

(1 citation statement)

References 38 publications

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“…ZFP41 is a type of ZFP, which play diverse roles in cell biological functions, such as cell differentiation, apoptosis, transcriptional regulation, cell metabolism and the immune response (45). current studies have found that ZFP41 plays a prominent role in tumor differentiation and oxidative stress, and is closely related to the co-expression of lacM and venous thromboembolism (46)(47)(48)(49). However, the role of ZFP41 in prognosis and cell function in Hcc has not yet been discovered.…”

Section: Discussionmentioning

confidence: 99%

Combining a glycolysis‑related prognostic model based on scRNA‑Seq with experimental verification identifies ZFP41 as a potential prognostic biomarker for HCC

Teng,

Xu,

Wang

et al. 2024

Mol Med Rep

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Hepatocellular carcinoma (HCC) is a common malignancy with a poor prognosis, and its heterogeneity affects the response to clinical treatments. Glycolysis is highly associated with HCC therapy and prognosis. The present study aimed to identify a novel biomarker for HCC by exploring the heterogeneity of glycolysis in HCC. The intersection of both marker genes of glycolysis-related cell clusters from single-cell RNA sequencing analysis and mRNA data of liver HCC from The Cancer Genome Atlas were used to construct a prognostic model through Cox proportional hazard regression and the least absolute shrinkage and selection operator Cox regression. Data from the International Cancer Genome Consortium were used to validate the results of the analysis. Immune status analysis was then conducted. A significant gene in the prognostic model was identified as a potential biomarker and was verified through in vitro experiments. The results revealed that the glycolysis-related prognostic model divided patients with HCC into high- and low-risk groups. A nomogram combining the model and clinical features exhibited accurate predictive ability, with an area under the curve of 0.763 at 3 years. The high-risk group exhibited a higher expression of checkpoint genes and lower tumor immune dysfunction and exclusion scores, suggesting that this group may be more likely to benefit from immunotherapy. The tumor tissues had a higher zinc finger protein (ZFP)41 mRNA and protein expression compared with the adjacent tissues. In vitro analyses revealed that ZFP41 played a crucial role in cell viability, proliferation, migration, invasion and glycolysis. On the whole, the present study demonstrates that the glycolysis-related prognostic gene, ZFP41, is a potential prognostic biomarker and therapeutic target, and may play a crucial role in glycolysis and malignancy in HCC.

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Section: Discussionmentioning

confidence: 99%

Combining a glycolysis‑related prognostic model based on scRNA‑Seq with experimental verification identifies ZFP41 as a potential prognostic biomarker for HCC

Teng,

Xu,

Wang

et al. 2024

Mol Med Rep

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Incidence of maternal venous thromboembolism in China: A systematic review and meta‐analysis

Luo

Shan

Zhang

et al. 2023

Intl J Gynecology & Obste

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BackgroundVenous thromboembolism (VTE) is one of the primary causes of maternal death. Although many studies have reported maternal VTE, no study has estimated the incidence of it in China.ObjectivesThe aim of this work was to estimate the incidence of maternal VTE in China and to compare the risk factors for it.Search strategyThe authors searched eight platforms and databases including PubMed, Embase, and Cochrane Library from inception to April 2022, with the search terms “venous thromboembolism” AND “puerperium (pregnancy)” AND “incidence” AND “China.”Selection criteriaStudies provide data to calculate the incidence of maternal VTE among Chinese patients.Data collection and analysisThe authors made a standardized table to collect data and calculated the incidence and 95% confidence intervals (CIs), founding source of heterogeneity by subgroup analysis and meta‐regression and judging publication bias by funnel plot and Egger test.Main resultsThe included 53 papers with a total sample size of 3 813 871 patients had 2539 cases of VTE, and the incidence of maternal VTE in China was 0.13% (95% CI, 0.11–0.16; P < 0.001).ConclusionsThe trend in the incidence of maternal VTE in China is stable. Cesarean section and advanced age are associated with a higher incidence of VTE.

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Whole exome sequencing identifies genetic variants in Chinese Han pregnant women with venous thromboembolism

Cited by 2 publications

References 38 publications

Combining a glycolysis‑related prognostic model based on scRNA‑Seq with experimental verification identifies ZFP41 as a potential prognostic biomarker for HCC

Combining a glycolysis‑related prognostic model based on scRNA‑Seq with experimental verification identifies ZFP41 as a potential prognostic biomarker for HCC

Incidence of maternal venous thromboembolism in China: A systematic review and meta‐analysis

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