Whole-Exome Sequencing of Bronchial Epithelial Cells Reveals a Genetic Print of Airway Remodelling in COPD

Germain, A; Perotin, Jeanne-Marie; Delépine, G.; Polette, Myriam; Deslée, G.; Dormoy, Valérian

doi:10.3390/biomedicines10071714

Cited by 2 publications

(1 citation statement)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Dysfunction of motile cilia was evaluated in the airways of COPD patients using a wide range of experimental tools from genetic studies to live imaging (table 1, [10,[37][38][39][40][41][42][43][44][45][46][47][48][49][50][51][52]). The main findings commonly included decreased CBF, shortening of motile cilia, and ciliary dyskinesia from the nasal epithelium to the bronchioles (table 1).…”

Section: Alteration Of Motile Ciliamentioning

confidence: 99%

Airway ciliated cells in adult lung homeostasis and COPD

Petit,

Belgacemi,

Ancel

et al. 2023

Eur Respir Rev

Self Cite

View full text Add to dashboard Cite

Cilia are organelles emanating from the cell surface, consisting of an axoneme of microtubules that extends from a basal body derived from the centrioles. They are either isolated and nonmotile (primary cilia), or grouped and motile (motile cilia). Cilia are at the centre of fundamental sensory processes and are involved in a wide range of human disorders. Pulmonary cilia include motile cilia lining the epithelial cells of the conductive airways to orchestrate mucociliary clearance, and primary cilia found on nondifferentiated epithelial and mesenchymal cells acting as sensors and cell cycle keepers. Whereas cilia are essential along the airways, their regulatory molecular mechanisms remain poorly understood, resulting in a lack of therapeutic strategies targeting their structure or functions. This review summarises the current knowledge on cilia in the context of lung homeostasis and COPD to provide a comprehensive overview of the (patho)biology of cilia in respiratory medicine with a particular emphasis on COPD.

show abstract

Section: Alteration Of Motile Ciliamentioning

confidence: 99%

Airway ciliated cells in adult lung homeostasis and COPD

Petit,

Belgacemi,

Ancel

et al. 2023

Eur Respir Rev

Self Cite

View full text Add to dashboard Cite

show abstract

PREVAX: A Phase I Clinical Trial of an EGF-Based Vaccine in Moderate-to-Severe COPD Patients

Hernandez Reyes,

Santos Morales,

Hernandez Moreno

et al. 2024

Vaccines

View full text Add to dashboard Cite

Background: EGFR has been suggested to contribute to COPD development and progression. Excessive ligand activation of the receptor leads to epithelial hyperproliferation and increased production of mucus, together with alterations in the primary cilia. The present study was designed to evaluate the safety and effect of depleting EGF in moderate-to-severe COPD patients, with an EGF-based vaccine. Patients and methods: A phase I trial was conducted in subjects with moderate or severe COPD. The anti-EGF vaccine schedule consisted of 4 biweekly doses followed by 4 monthly boosters. The primary endpoint was the evaluation of the safety and immunogenicity of the vaccine, together with the change in FEV1 and physical function at week 24. Results: Twenty-six patients with moderate or severe COPD were included in the trial. The vaccine was well tolerated and no serious related adverse events were reported. Ninety percent of the individuals developed a protective antibody response. The specific anti-EGF antibodies had high avidity and were able to inhibit EGFR phosphorylation. At the end of vaccination, serum EGF became undetectable. At week 24, there was a clinically significant improvement in lung function, with a mean change in trough FEV1 of 106 mL. Patients also increased their physical functioning. Conclusions: The EGF-based vaccine was immunogenic and provoked an EGF exhaustion in patients with moderate-to-severe COPD. Depleting EGF might result in a meaningful increase in FEV1, with good tolerability. The current results provide new avenues to treat chronic inflammatory lung diseases associated with EGFR aberrant signaling.

show abstract

Whole-Exome Sequencing of Bronchial Epithelial Cells Reveals a Genetic Print of Airway Remodelling in COPD

Cited by 2 publications

References 19 publications

Airway ciliated cells in adult lung homeostasis and COPD

Airway ciliated cells in adult lung homeostasis and COPD

PREVAX: A Phase I Clinical Trial of an EGF-Based Vaccine in Moderate-to-Severe COPD Patients

Contact Info

Product

Resources

About