Whole exome sequencing of primary cutaneous CD4+ small/medium T‐cell lymphoproliferative disorders

Abstract

Primary cutaneous CD4+ T-cell lymphoproliferative disorder (PCSMLPD) is an uncommon T-cell proliferation, which generally presents as an asymptomatic solitary slow-growing erythematous papule or plaque in the head and neck region. Histologically, these lymphoproliferations are characterized by dense dermal infiltrates of predominantly small-to medium-sized pleomorphic lymphocytes, with a variable but minor proportion of large lymphocytes. The lesional cells show a T-follicular helper (TFH) immunophenotype and the majority, but not all, demonstrate clonal