Whole flaxseed consumption lowers serum LDL-cholesterol and lipoprotein(a) concentrations in postmenopausal women

Arjmandi, Bahram H.; Khan, Dilshad Ahmed; Juma, Shanil; Drum, Melinda L.; Venkatesh, S; Sohn, Eugenia; Wei, Li-Li; Derman, Richard

doi:10.1016/s0271-5317(98)00100-6

Cited by 99 publications

(74 citation statements)

References 29 publications

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“…Others (Finnegan et al, 2003a, b) reported an increase in plasma ALA with 4.5 and 9.5 g of ALA per day supplementation after 3 and 6 months in groups with an average age of B50 years. Studies for this age group using ground flaxseed have been carried out in patients with lupus nephritis (Clark et al, 1995(Clark et al, , 2001) and in hypercholesterolemic postmenopausal women (Arjmandi et al, 1998;Lemay et al, 2002). In most of these investigations, ALA concentrations were increased after the dietary supplementation.…”

Section: Discussionmentioning

confidence: 99%

Bioavailability of α-linolenic acid from flaxseed diets as a function of the age of the subject

et al. 2009

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Background: Dietary flaxseed may have beneficial cardiovascular effects. An aged population has a higher incidence of cardiovascular disease, but they may react differently to flaxseed in the diet. Objective: To investigate the response, over a period of 4 weeks, of subjects aged 18-29 or 45-69 years to a diet containing the same amount of a-linolenic acid (ALA) (6 g) introduced in the form of ground flaxseed (30 g) or flaxseed oil. Results: All subjects who received flaxseed oil showed a significant increase in plasma ALA and eicosapentaenoic acid (EPA) concentrations over the course of this study. Subjects who received ground flaxseed in the 18-29-year-old group showed a statistically significant increase in their plasma ALA levels, and although there was a trend in the same direction for the 45-69-year-old subjects, this did not achieve statistical significance. The diets induced no major changes in platelet aggregation, plasma total cholesterol, low-density lipoprotein or high-density lipoprotein cholesterol levels in any of the groups. Younger subjects showed a decrease in triglyceride (TG) values compared with older subjects. There were no significant side effects that caused compliancy issues. Conclusion: Subject age does not seem to be a major determining factor in influencing ALA absorption from a flaxseedsupplemented diet nor in the metabolism of ALA to EPA in the groups fed flaxseed oil. Concerns about side effects in older subjects administered a higher fiber load in a flaxseed-supplemented diet are not justified. However, younger but not older subjects showed a beneficial decrease in circulating TGs due to flaxseed supplementation.

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Section: Discussionmentioning

confidence: 99%

Bioavailability of α-linolenic acid from flaxseed diets as a function of the age of the subject

et al. 2009

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“…Patenaude et al compared the effect of increased consumption of ALA, from flaxseed oil (6 g/d for 4 weeks), in two age groups and reported a 20% decrease in circulating TAG concentration in younger subjects (18-29 y) compared to a 3.5% increase in older subjects (45-69 y) [144]. Some studies which directly compare the effects of ALA and LA on fasting TAG concentrations suggest that the effects of ALA are not markedly different from those of LA [134,229,231,232,240], while others describe higher TAG concentrations after increased ALA intake but not after a high-LA diet [124,227]. For example, Bemelmans et al reported 12% higher plasma TAG concentrations after ALA than after LA [119].…”

Section: Alpha-linolenic and Stearidonic Acids And Cardiovascular Rismentioning

confidence: 99%

Metabolism and functional effects of plant-derived omega-3 fatty acids in humans

Baker

Miles

Burdge

et al. 2016

Progress in Lipid Research

354

292

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“…The investigators found that there were significant reductions in total cholesterol in both the flaxseed (6.9 %) and the sunflower seed (5.5 %) groups. Notably, only the flaxseed group saw significant reductions in LDL-cholesterol (14.7 %) and lipoprotein(a) (7.4 %) when compared to the baseline levels [72]. As compared to whole flaxseed, the addition of 30 g/day of ground flaxseed did not lower total cholesterol and LDL-cholesterol more than a low-fat diet in a study of 161 prostate cancer patients [73].…”

Section: Flaxseedmentioning

confidence: 89%

Dietary Supplements for Cholesterol Management

Almandoz

2015

Contemporary Endocrinology

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Whole flaxseed consumption lowers serum LDL-cholesterol and lipoprotein(a) concentrations in postmenopausal women

Cited by 99 publications

References 29 publications

Bioavailability of α-linolenic acid from flaxseed diets as a function of the age of the subject

Bioavailability of α-linolenic acid from flaxseed diets as a function of the age of the subject

Metabolism and functional effects of plant-derived omega-3 fatty acids in humans

Dietary Supplements for Cholesterol Management

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