Whole-Genome Sequence of the Fruiting Myxobacterium Cystobacter fuscus DSM 52655

Treuner-Lange, Anke; Bruckskotten, Marc; Rupp, Oliver; Goesmann, Alexander; Søgaard‐Andersen, Lotte

doi:10.1128/genomea.01196-17

Cited by 3 publications

(2 citation statements)

References 39 publications

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“…The Gram-negative Cystobacter genus is comprised of seven validly published species (available at: https://lpsn.dsmz.de/genus/cystobacter ) and although previous taxonomic studies have indicated that this genus belongs to the Archangiaceae family, a recent study by Waite et al (2020) proposed its reclassification as a member of the Myxococcaceae family, within the Myxococcales order. These myxobacteria are ubiquitous in soil environments and similar to Myxococcus species, Cystobacter utilise gliding motility to move over surfaces, and are also able to form spore-filled fruiting bodies when subjected to unfavourable conditions ( Akbar et al, 2017 ; Treuner-Lange et al, 2017 ). However, the Cystobacter fruiting bodies differ in morphology to those of the Myxococcus genus, and are shiny, spherical and held within a slime matrix, whereas the latter are characterised by haystack-shaped cell aggregates ( Treuner-Lange et al, 2017 ).…”

Section: Antimicrobial Lipopeptides: Production By Underexplored Pred...mentioning

confidence: 99%

“…These myxobacteria are ubiquitous in soil environments and similar to Myxococcus species, Cystobacter utilise gliding motility to move over surfaces, and are also able to form spore-filled fruiting bodies when subjected to unfavourable conditions ( Akbar et al, 2017 ; Treuner-Lange et al, 2017 ). However, the Cystobacter fruiting bodies differ in morphology to those of the Myxococcus genus, and are shiny, spherical and held within a slime matrix, whereas the latter are characterised by haystack-shaped cell aggregates ( Treuner-Lange et al, 2017 ). Cystobacter species have a relatively large genome size, thus enabling them to produce a vast range of secondary metabolites, including bacteriocins, polyketides, lantipeptides and microcins ( Saadatpour and Mohammadipanah, 2020 ).…”

Section: Antimicrobial Lipopeptides: Production By Underexplored Pred...mentioning

confidence: 99%

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Underexplored bacteria as reservoirs of novel antimicrobial lipopeptides

et al. 2022

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Natural products derived from microorganisms play a prominent role in drug discovery as potential anti-infective agents. Over the past few decades, lipopeptides produced by particularly Bacillus, Pseudomonas, Streptomyces, Paenibacillus, and cyanobacteria species, have been extensively studied for their antimicrobial potential. Subsequently, daptomycin and polymyxin B were approved by the Food and Drug Administration as lipopeptide antibiotics. Recent studies have however, indicated that Serratia, Brevibacillus, and Burkholderia, as well as predatory bacteria such as Myxococcus, Lysobacter, and Cystobacter, hold promise as relatively underexplored sources of novel classes of lipopeptides. This review will thus highlight the structures and the newly discovered scaffolds of lipopeptide families produced by these bacterial genera, with potential antimicrobial activities. Additionally, insight into the mode of action and biosynthesis of these lipopeptides will be provided and the application of a genome mining approach, to ascertain the biosynthetic gene cluster potential of these bacterial genera (genomes available on the National Center for Biotechnology Information) for their future pharmaceutical exploitation, will be discussed.

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Section: Antimicrobial Lipopeptides: Production By Underexplored Pred...mentioning

confidence: 99%

Section: Antimicrobial Lipopeptides: Production By Underexplored Pred...mentioning

confidence: 99%

Underexplored bacteria as reservoirs of novel antimicrobial lipopeptides

et al. 2022

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Myxobacteria: biology and bioactive secondary metabolites

Saggu

Nath

Kumar

2023

Research in Microbiology

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In silico characterization of a novel putative aerotaxis chemosensory system in the myxobacterium, Corallococcus coralloides

2018

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BackgroundAn efficient signal transduction system allows a bacterium to sense environmental cues and then to respond positively or negatively to those signals; this process is referred to as taxis. In addition to external cues, the internal metabolic state of any bacterium plays a major role in determining its ability to reside and thrive in its current environment. Similar to external signaling molecules, cytoplasmic signals are also sensed by methyl-accepting chemotaxis proteins (MCPs) via diverse ligand binding domains. Myxobacteria are complex soil-dwelling social microbes that can perform a variety of physiologic and metabolic activities ranging from gliding motility, sporulation, biofilm formation, carotenoid and secondary metabolite biosynthesis, predation, and slime secretion. To live such complex lifestyles, they have evolved efficient signal transduction systems with numerous one- and two-component regulatory system along with a large array of chemosensory systems to perceive and integrate both external and internal cues.ResultsHere we report the in silico characterization of a putative energy taxis cluster, Cc-5, which is present in only one amongst 34 known and sequenced myxobacterial genomes, Corallococcus coralloides. In addition, we propose that this energy taxis cluster is involved in oxygen sensing, suggesting that C. coralloides can sense (either directly or indirectly) and then respond to changing concentrations of molecular oxygen.ConclusionsThis hypothesis is based on the presence of a unique MCP encoded in this gene cluster that contains two different oxygen-binding sensor domains, PAS and globin. In addition, the two monooxygenases encoded in this cluster may contribute to aerobic respiration via ubiquinone biosynthesis, which is part of the cytochrome bc1 complex. Finally, we suggest that this cluster was acquired from Actinobacteria, Gammaproteobacteria or Cyanobacteria. Overall, this in silico study has identified a potentially innovative and evolved mechanism of energy taxis in only one of the myxobacteria, C. coralloides.Electronic supplementary materialThe online version of this article (10.1186/s12864-018-5151-6) contains supplementary material, which is available to authorized users.

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Whole-Genome Sequence of the Fruiting Myxobacterium Cystobacter fuscus DSM 52655

Cited by 3 publications

References 39 publications

Underexplored bacteria as reservoirs of novel antimicrobial lipopeptides

Underexplored bacteria as reservoirs of novel antimicrobial lipopeptides

Myxobacteria: biology and bioactive secondary metabolites

In silico characterization of a novel putative aerotaxis chemosensory system in the myxobacterium, Corallococcus coralloides

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