In the present work, a bionanocomposite for plant crop protection was prepared by non‐toxic biocompatible & biodegradable nanomaterials (Cellulose & TiO2) to utilize its synergistic effects against antimicrobial pathogens. The commercially available microcrystalline cellulose has been reduced to a nanometric scale regime using acid hydrolysis, while the standard TiO2 nano‐powder of particle size ~20nm has been used to prepare their nanocomposite (NC). The antibacterial studies via agar well diffusion method demonstrated that after 72 hrs of incubation, parent nanomaterials Ncell and TiO2 were not showing any activity against phytopathogens X. campestris pv. campestris, and Clavibacter while the nanocomposite’s NC’s were still effective depicting both bacteriostatic and bactericidal actions. However, the bacterial growth of biocontrol P. fluorescence was not affected by Ncell, TiO2 NPs and NC after 72hrs of incubation. The antifungal testing results via poison food agar assay method suggest that the nanocomposite, along with Ncell and TiO2 NPs, exhibited strong inhibition of fungal growth of Phytophthora Spp at 0.125mg/ml concentration while for F. graminearum, similar effect was observed at 0.25mg/ml concentration. The nanocomposite has proved its potential by exhibiting longer & stronger synergestic effects against plant pathogens as a good antimicrobial agent for protection of agricultural crops.