2021
DOI: 10.1016/j.jaci.2020.08.003
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Whole genome sequencing identifies genetic variants associated with co-trimoxazole hypersensitivity in Asians

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Cited by 57 publications
(61 citation statements)
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“…A multicenter case-control study collecting data from Taiwan, Thailand, and Malaysia showed a strong association between HLA-B*13:01 allele with co-trimoxazole induced SCARs (OR: 8.7, 95% CI 5.7-13.4; p = 7.2 × 10 −21) driven from SJS/TEN(OR: 2.71, 95% CI 3-5.4; p = 0.006) and DRESS (OR: 45, 95% CI 18.7-134; p = 1.1 × 10 −26 ). After meta-analysis of data from Taiwan, Thailand and Malaysia and phenotype stratification indicated a strong association between HLA-B*13:01 allele and co-trimoxazole induced DRESS (OR: 40.1, 95% CI 19.54-82.32; p < 0.00001 [181]. Another case-control study conducted only in Thai patients lead by Sukasem C et al 2020 demonstrated that genetic association of cotrimoxazole driven SCARs was phenotype-specific in which HLA-B*15:02 and HLA-C*08:01 alleles were significantly associated with cotrimoxazole induced SJS/TEN only.…”
Section: Cotrimoxazolementioning
confidence: 99%
“…A multicenter case-control study collecting data from Taiwan, Thailand, and Malaysia showed a strong association between HLA-B*13:01 allele with co-trimoxazole induced SCARs (OR: 8.7, 95% CI 5.7-13.4; p = 7.2 × 10 −21) driven from SJS/TEN(OR: 2.71, 95% CI 3-5.4; p = 0.006) and DRESS (OR: 45, 95% CI 18.7-134; p = 1.1 × 10 −26 ). After meta-analysis of data from Taiwan, Thailand and Malaysia and phenotype stratification indicated a strong association between HLA-B*13:01 allele and co-trimoxazole induced DRESS (OR: 40.1, 95% CI 19.54-82.32; p < 0.00001 [181]. Another case-control study conducted only in Thai patients lead by Sukasem C et al 2020 demonstrated that genetic association of cotrimoxazole driven SCARs was phenotype-specific in which HLA-B*15:02 and HLA-C*08:01 alleles were significantly associated with cotrimoxazole induced SJS/TEN only.…”
Section: Cotrimoxazolementioning
confidence: 99%
“…Co-trimoxazole (CTX), the sulfamethoxazole-trimethoprim combination drug, has been known to cause SCARs, and HLA-B * 15:02 and HLA-C * 08:01 were significantly associated with CTX-induced SJS/TEN, and HLA-B * 13:01 was associated with CTX-induced DRESS in Thai population (22). Moreover, genome-wide association study in CTX hypersensitivity in collaboration of Taiwan, Thai and Malaysia confirmed that HLA-B * 13:01 was strongly associated with its SCARs (23). Recently, association between HLA * 11:01 and sulfonamide-related SCAR was shown in Japanese patients (24).…”
Section: Other Drugsmentioning
confidence: 88%
“…Recent advance in the technology of pharmacogenomic studies have showed more genetic risk factors associated with SCARs, not only in genes of HLA and other immune pathways, but also in drug metabolism or elimination. The genetic approach for the pharmacogenomics studies for SCAR has been evolved from sequencing based genotyping with polymerase chain reaction (PCR), such as HLA genotypes (15) to more comprehensive approaches, including genome-wide association study (GWAS) and next-generation sequencing (NGS), in discovering the relationship between adverse drug reactions (ADRs) and genotyping, and discovered more non-HLA loci (15)(16)(17).…”
Section: Molecular Mechanism and Susceptible Genes Related To Severe Cutaneous Adverse Reactionsmentioning
confidence: 99%