Whole-Genome Sequencing of Inbred Mouse Strains Selected for High and Low Open-Field Activity

Thomas, Aimee L; Evans, Luke M.; Nelsen, Michaela D.; Chesler, Elissa J.; Powers, Matthew S.; Booher, Winona C.; Lowry, Christopher A.; DeFries, John C.; Ehringer, Marissa A.

doi:10.1007/s10519-020-10014-y

Cited by 7 publications

(37 citation statements)

References 46 publications

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“…SAP is associated with increased anxiety-like behaviors. 28,31 During both OFA trials, male and female Low Activity mice exhibited this behavior significantly more often than their High Activity counterparts. This behavior resulted in a longer latency for the Low Activity mice to leave the center.…”

Section: Femalementioning

confidence: 90%

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Anxiety‐related defensive behavioral responses in mice selectively bred for High and Low Activity

Booher

Hall

Thomas

et al. 2021

Genes Brain and Behavior

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High and Low Activity strains of mice (displaying low and high anxiety-like behavior, respectively) with 7.8-20 fold differences in open-field activity were selected and subsequently inbred to use as a genetic model for studying anxiety-like behavior in mice (DeFries et al., 1978, Behavior Genetics, 8:3-13). These strains exhibited differences in other anxiety-related behaviors as assessed using the light-dark box, elevated plus-maze, mirror chamber, and elevated square-maze tests (Henderson et al., 2004, Behavior Genetics, 34: 267-293). The purpose of these experiments was three-fold. First, we repeated a 6-day behavioral battery using updated equipment

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Section: Femalementioning

confidence: 90%

“…SAP occurs during risk-assessment and is generally associated with anxiety. 28 In order to best compare the results of the current study to past studies, the behavioral battery was performed in a manner similar to that in Henderson et al 22 except we replaced the mirror box and square maze with novel object exploration.…”

Section: Introductionmentioning

confidence: 99%

Anxiety‐related defensive behavioral responses in mice selectively bred for High and Low Activity

Booher

Hall

Thomas

et al. 2021

Genes Brain and Behavior

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“…Pre-registration: We preregistered our study on the Open Science Framework website (https://osf.io/nzwyf/) on 07/22/2021, after defining mouse gene sets from Thomas et al (2021) 6 , but before estimating gene set associations and LDSC-based SNP-heritability in human traits.…”

Section: Methodsmentioning

confidence: 99%

“…Mouse Anxiety-like Behavior Genes and Gene Sets: Thomas et al (2021) 6 identified sets of genes that were reported as differentially expressed in association with anxiety-like behaviors in rodent models or were within rodent anxiety-like behavior quantitative trait loci (QTL) regions by publications within the GeneWeaver database 18 (for specifics on the collection see Thomas et al (2021)). Here, we used mouse model data from Thomas et al (2021) for this investigation, since the collection of mice contained the most extensive set of experimental analyses and results of the available animal models. These sets consisted of 4 260 genes from seven different publications of mouse differential gene expression, as well as 8 104 genes from five publications of mouse anxiety-like behavior QTL analyses.…”

Section: Methodsmentioning

confidence: 99%

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Testing Human Anxiety Associations of Genes Previously Implicated by Mouse Anxiety Models

Brasher

Mize

Thomas³

et al. 2022

Preprint

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Anxiety disorders are common and can be debilitating, with effective treatments remaining hampered by an incomplete understanding of the underlying genetic etiology. Improvements have been made in understanding the genetic influences on mouse behavioral models of anxiety, yet it is unclear the extent to which genes identified in these experimental systems contribute to genetic variation in human anxiety phenotypes. Leveraging new and existing large-scale human genome-wide association studies, we tested whether sets of genes previously identified in mouse anxiety-like behavior studies contribute to a range of human anxiety disorders. When tested as individual genes, thirteen mouse-identified genes were associated with human anxiety phenotypes, suggesting an overlap of individual genes contributing to both mouse models of anxiety-like behaviors and human anxiety traits. When genes were tested as sets, we did identify fourteen significant associations between mouse gene sets and human anxiety, but the majority of gene sets showed no significant association with human anxiety phenotypes. These few significant associations indicate a need to identify and develop more translatable mouse models by identifying sets of genes that 'match' between model systems and specific human phenotypes of interest. We suggest that continuing to develop improved behavioral paradigms and finer-scale experimental data, for instance from individual neuronal subtypes or cell-type-specific expression data, is likely to improve our understanding of the genetic etiology and underlying functional changes in anxiety disorders.

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Announcement of the Fulker Award for a Paper Published in Behavior Genetics, Volume 51, 2021

2022

Behav Genet

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Whole-Genome Sequencing of Inbred Mouse Strains Selected for High and Low Open-Field Activity

Cited by 7 publications

References 46 publications

Anxiety‐related defensive behavioral responses in mice selectively bred for High and Low Activity

Anxiety‐related defensive behavioral responses in mice selectively bred for High and Low Activity

Testing Human Anxiety Associations of Genes Previously Implicated by Mouse Anxiety Models

Announcement of the Fulker Award for a Paper Published in Behavior Genetics, Volume 51, 2021

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