Whole-genome sequencing of SARS-COV-2 showed wide spread of B.1.525 in February 2021 in Libya

Alhudiri, Inas M; Ramadan, Ahmad M.; Ibrahim, Khaled; ElJilani, Mouna Mohamed; Aboud, Adel Abdalla; Salem, Mohamed Ali; Elgheriani, Hajer Mohamed; Elzagheid, Adam

doi:10.1101/2021.07.03.21257942

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“…SARS-COV-2 samples from Libya were regrettably not confirmed by genome sequencing during that time; instead, tracking relied on RT-qPCR assays that targeted the presence of the L452R and P681R mutations. However, samples collected around the end of February and beginning of March 2021 had their genomes sequenced, and the majority of cases were B.1.525, with only 2% being an alpha variant (32). Hence, we believe that most of SARS-COV-2 infection in May and beginning of June 2021 was B.1.525 variant.…”

Section: Discussionmentioning

confidence: 99%

Impact of vaccination and risk factors on COVID-19 mortality amid delta wave in Libya: a single centre cohort study

Alhudiri¹,

Abusrewil

Dakhil³

et al. 2023

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Background The Delta variant has led to a surge in COVID-19 cases in Libya, making it crucial to investigate the impact of vaccination on mortality rates among hospitalized patients and critically ill. Aims To study risk factors and COVID-19 mortality rates among unvaccinated and vaccinated adults during delta wave at a single COVID-19 care centre in Tripoli, Libya. Methods The study involved two independent cohorts (n=341). One cohort was collected retrospectively from May 2021-August 2021 and the second cohort was prospectively collected from August 2021-October 2021 and most of them were during the Delta wave. The two cohorts were merged and analysed as one group. Results Most patients were male (60.5%) and 53.3% were >60 years. The vast majority of admitted patients did not have previous COVID-19 infection (98.9%) and were unvaccinated (90.3%). Among vaccinated, 30 patients had one dose and only 3 had two doses. Among patients who received one dose, 58.1% (18/31) died and 41.9% (13/31) survived. Most patients (72.2%) had a pre-existing medical condition. Multivariable prediction model showed that age >60 years was significantly associated with death (odds ratio=2.328, CI 1.456-3.724, p-value=<0.0001). Conclusion Previous infection or full vaccination against COVID-19 significantly reduces hospitalization and death, as most admitted patients were unvaccinated and not previously infected. However, a single vaccine dose may not be adequate, especially for older individuals and those with underlying medical conditions. High-risk older patients with comorbidities should be fully vaccinated and offered up to date bivalent COVID-19 booster doses.

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Section: Discussionmentioning

confidence: 99%