2018
DOI: 10.1039/c8ew00395e
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Whole metagenome sequencing of chlorinated drinking water distribution systems

Abstract: This research highlights the potential of whole metagenome sequencing to help protect drinking water quality and safety.

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Cited by 46 publications
(48 citation statements)
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“…Considering that the microbiome structure is closely related to their functions, we used PICRUSt software to predict the functional changes under QSI treatment. Results showed that the main biological functions associated with biofilm formation included carbohydrate and protein metabolism, as well as polysaccharide biosynthesis ( Figure 6 A), which is consist with the results of Douterelo [ 41 ]. Among the functional groups detected, the most significant one is chemotaxis.…”
Section: Discussionsupporting
confidence: 85%
“…Considering that the microbiome structure is closely related to their functions, we used PICRUSt software to predict the functional changes under QSI treatment. Results showed that the main biological functions associated with biofilm formation included carbohydrate and protein metabolism, as well as polysaccharide biosynthesis ( Figure 6 A), which is consist with the results of Douterelo [ 41 ]. Among the functional groups detected, the most significant one is chemotaxis.…”
Section: Discussionsupporting
confidence: 85%
“…The high abundance of beta-lactam resistance in the warmer samples here might be explained by the dominance of genus Pseudomonas, some species of which were documented to be the host of beta-lactam resistance genes (Torrens et al, 2019). The pathway of GSH metabolism, a typical mechanism for protecting cell from oxidative damage (Douterelo et al, 2018), was discovered abundantly in all samples. This is reasonable because the residual chlorine in the bulk water could stimulate the synthesis of GSH: GSH-reductase reduced the disulphide of GSH to sulfhydryl (Kehrer et al, 2010), which played an important role in resisting oxidative stress of free chlorine.…”
Section: Biofilmmentioning
confidence: 76%
“…Culture-dependent methods are used to detect and enumerate indicator organisms and have been remarkably successful in improving DW quality and safety, but do not detect all microorganisms present in that water. Metagenomic analysis employing high-throughput sequencing coupled with bioinformatics has gained attention during the past decade, allowing detection, identification, and characterization of all microorganisms present in DWDS [22][23][24]. Inferences of infectious potential of detected microbial species is determined by detecting genes coding for pathogenic and metabolic properties [24,25].…”
Section: Introductionmentioning
confidence: 99%
“…Metagenomic analysis employing high-throughput sequencing coupled with bioinformatics has gained attention during the past decade, allowing detection, identification, and characterization of all microorganisms present in DWDS [22][23][24]. Inferences of infectious potential of detected microbial species is determined by detecting genes coding for pathogenic and metabolic properties [24,25]. Thus, bacteria, viruses, fungi, and protists now can be detected, identified to sub-species level, and characterized.…”
Section: Introductionmentioning
confidence: 99%