Whole red paprika (Capsicum annuum L.) and its orange-red pigment capsanthin ameliorate obesity-induced skeletal muscle atrophy in mice

Kim, Young In; Kim, Jisun; Lee, Hyunjung; Jung, Chang Hwa; Ahn, Jiyun

doi:10.1016/j.jff.2023.105624

Cited by 3 publications

(2 citation statements)

References 39 publications

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“…C2C12 myoblast cells begin to express myogenin upon almost reaching 100% confluency, and it upregulates after the switch to the differentiation medium for five days to matured myotubes [ 24 ]. Therefore, C2C12 differentiation to matured myofibers and PA induction occurred as previously described [ 25 ]. To induce myogenic differentiation, the C2C12 myoblasts were seeded at the density of 1 × 10 5 cells/well in 6-well culture dishes.…”

Section: Methodsmentioning

confidence: 99%

Gromwell (Lithospermum erythrorhizon) Attenuates High-Fat-Induced Skeletal Muscle Wasting by Increasing Protein Synthesis and Mitochondrial Biogenesis

Kim,

Lee,

Yoo

et al. 2023

J. Microbiol. Biotechnol.

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Gromwell ( Lithospermum erythrorhizon , LE) can mitigate obesity-induced skeletal muscle atrophy in C2C12 myotubes and high-fat diet (HFD)-induced obese mice. The purpose of this study was to investigate the anti-skeletal muscle atrophy effects of LE and the underlying molecular mechanism. C2C12 myotubes were pretreated with LE or shikonin, and active component of LE, for 24 h and then treated with 500 μM palmitic acid (PA) for an additional 24 h. Additionally, mice were fed a HFD for 8 weeks to induced obesity, and then fed either the same diet or a version containing 0.25% LE for 10 weeks. LE attenuated PA-induced myotubes atrophy in differentiated C2C12 myotubes. The supplementation of LE to obese mice significantly increased skeletal muscle weight, lean body mass, muscle strength, and exercise performance compared with those in the HFD group. LE supplementation not only suppressed obesity-induced skeletal muscle lipid accumulation, but also downregulated TNF-α and atrophic genes. LE increased protein synthesis in the skeletal muscle via the mTOR pathway. We observed LE induced increase of mitochondrial biogenesis and upregulation of oxidative phosphorylation related genes in the skeletal muscles. Furthermore, LE increased the expression of peroxisome proliferator-activated receptor-gamma coactivator-1 alpha and the phosphorylation of adenosine monophosphate-activated protein kinase. Collectively, LE may be useful in ameliorating the detrimental effects of obesity-induced skeletal muscle atrophy through the increase of protein synthesis and mitochondrial biogenesis of skeletal muscle.

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Section: Methodsmentioning

confidence: 99%

Gromwell (Lithospermum erythrorhizon) Attenuates High-Fat-Induced Skeletal Muscle Wasting by Increasing Protein Synthesis and Mitochondrial Biogenesis

Kim,

Lee,

Yoo

et al. 2023

J. Microbiol. Biotechnol.

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“…These effects were also analyzed in combination with orlistat. Similarly, C57BL/6N mice treated with carotenoids from red paprika (e.g., α -carotene, β -carotene, capsorubin, lutein, and zeaxanthin) showed enhanced endurance exercise capacity, increased muscle weights of limbs, and diminished intramyocellular fat accumulation, prevented the degradation of muscle protein through the activation of the mTOR pathway, and enhanced mitochondrial dysfunction [ 109 ].…”

Section: Carotenoids: Sources Extraction Characterization and Activit...mentioning

confidence: 99%

Recent Advances in the Therapeutic Potential of Carotenoids in Preventing and Managing Metabolic Disorders

Ortega-Regules,

Martínez-Thomas,

Schürenkämper-Carrillo

et al. 2024

Plants

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Carotenoids constitute compounds of significant biological interest due to their multiple biological activities, such as antimicrobial, anticancer, antiadipogenic, antidiabetic, and antioxidant properties. Metabolic syndrome (MetS) comprehends a series of metabolic abnormalities (e.g., hypertension, obesity, and atherogenic dyslipidemia) that can affect children, adolescents, and the elderly. The treatment of MetS involves numerous medications, which, despite their efficacy, pose challenges due to prolonged use, high costs, and various side effects. Carotenoids and their derivatives have been proposed as alternative treatments to MetS because they reduce serum triglyceride concentrations, promote insulin response, inhibit adipogenesis, and downregulate angiotensin-converting enzyme activity. However, carotenoids are notably sensitive to pH, light exposure, and temperature. This review addresses the activity of carotenoids such as lycopene, lutein, fucoxanthin, astaxanthin, crocin, and β-carotene towards MetS. It includes a discussion of sources, extraction methods, and characterization techniques for analyzing carotenoids. Encapsulation approaches are critically reviewed as alternatives to prevent degradation and improve the biological performance of carotenoids. A brief overview of the physiopathology and epidemiology of the diseases, including MetS, is also provided.

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Ginseng berry extract and ginsenoside Re enhance exercise performance through mitochondrial biogenesis in high-fat induced skeletal muscle atrophy

Kim,

Yoon,

Shin

et al. 2024

Journal of Functional Foods

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Whole red paprika (Capsicum annuum L.) and its orange-red pigment capsanthin ameliorate obesity-induced skeletal muscle atrophy in mice

Cited by 3 publications

References 39 publications

Gromwell (Lithospermum erythrorhizon) Attenuates High-Fat-Induced Skeletal Muscle Wasting by Increasing Protein Synthesis and Mitochondrial Biogenesis

Gromwell (Lithospermum erythrorhizon) Attenuates High-Fat-Induced Skeletal Muscle Wasting by Increasing Protein Synthesis and Mitochondrial Biogenesis

Recent Advances in the Therapeutic Potential of Carotenoids in Preventing and Managing Metabolic Disorders

Ginseng berry extract and ginsenoside Re enhance exercise performance through mitochondrial biogenesis in high-fat induced skeletal muscle atrophy

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