Whole slide imaging for teleconsultation and clinical use

Dangott, Bryan; Parwani, Anil V.

doi:10.4103/2153-3539.65342

Cited by 21 publications

(15 citation statements)

References 2 publications

(1 reference statement)

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“…Validation should address both technical and interpretative components, and must be 19 14 Concordance and minor discordance between WSI and glass slides, % 12,13,42,45 93 98 a P , .001 versus glass slide (nonrandom). …”

Section: Resultsmentioning

confidence: 99%

“…Specific microscopic details (eg, organisms, nuclear atypia, apoptosis, mitotic figures, eosinophil granules) were sometimes noted to be difficult to identify because of poor image resolution on high magnification or went undetected (eg, minute focus of prostate adenocarcinoma) in the digital image. [19][20][21][22] It was also observed by some investigators that the time required to review a virtual slide took longer than that needed to examine a glass slide.…”

mentioning

confidence: 99%

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Validating Whole Slide Imaging for Diagnostic Purposes in Pathology: Guideline from the College of American Pathologists Pathology and Laboratory Quality Center

Pantanowitz

Sinard

Henricks

et al. 2013

Archives of Pathology & Laboratory Medicine

520

495

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Context.-There is increasing interest in using whole slide imaging (WSI) for diagnostic purposes (primary and/ or consultation). An important consideration is whether WSI can safely replace conventional light microscopy as the method by which pathologists review histologic sections, cytology slides, and/or hematology slides to render diagnoses. Validation of WSI is crucial to ensure that diagnostic performance based on digitized slides is at least equivalent to that of glass slides and light microscopy. Currently, there are no standard guidelines regarding validation of WSI for diagnostic use.Objective.-To recommend validation requirements for WSI systems to be used for diagnostic purposes.Design.-The College of American Pathologists Pathology and Laboratory Quality Center convened a nonvendor panel from North America with expertise in digital pathology to develop these validation recommendations. A literature review was performed in which 767 international publications that met search term requirements were identified. Studies outside the scope of this effort and those related solely to technical elements, education, and image analysis were excluded. A total of 27 publications were graded and underwent data extraction for evidence evaluation. Recommendations were derived from the strength of evidence determined from 23 of these published studies, open comment feedback, and expert panel consensus.Results.-Twelve guideline statements were established to help pathology laboratories validate their own WSI systems intended for clinical use. Validation of the entire WSI system, involving pathologists trained to use the system, should be performed in a manner that emulates the laboratory's actual clinical environment. It is recommended that such a validation study include at least 60 routine cases per application, comparing intraobserver diagnostic concordance between digitized and glass slides viewed at least 2 weeks apart. It is important that the validation process confirm that all material present on a glass slide to be scanned is included in the digital image.Conclusions.-Validation should demonstrate that the WSI system under review produces acceptable digital slides for diagnostic interpretation. The intention of validating WSI systems is to permit the clinical use of this technology in a manner that does not compromise patient care.

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Section: Resultsmentioning

confidence: 99%

mentioning

confidence: 99%

Validating Whole Slide Imaging for Diagnostic Purposes in Pathology: Guideline from the College of American Pathologists Pathology and Laboratory Quality Center

Pantanowitz

Sinard

Henricks

et al. 2013

Archives of Pathology & Laboratory Medicine

520

495

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“…One study suggested that the interobserver agreement was better for neoplastic than for nonneoplastic diseases [16]. It has been suggested that a scanning magnification of ×200 may not be sufficient to allow correct diagnosis in inflammatory lesions [82]. …”

Section: Surgical Pathologymentioning

confidence: 99%

Validation of Whole-Slide Imaging for Histolopathogical Diagnosis: Current State

et al. 2016

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Rapid advances in informatics and technological improvements have led to the development of high-throughput whole-slide imaging (WSI) scanners able to produce high-quality digital images, which allow achieving a correct diagnosis of the biopsies using virtual viewers. This technology is currently prepared to be introduced in the departments of pathology for routine diagnosis. The aim of this review is to analyze the current evidence regarding the use of WSI in primary or routine diagnosis in the different subspecialties of pathology. An increasing number of studies have shown almost perfect inter- and intraobserver agreement between the diagnoses obtained with WSI and the classical diagnoses based on conventional light microscopy. The only exception seems to be cytology, which still requires some technological development. Although validation studies are needed in some areas of pathology, growing evidence indicates that WSI is a reliable tool for routine diagnosis. Pathologists have a positive perception of the ergonomics of the workstations, the low magnification of WSI and the possibility of making annotations and measurements. WSI can be used from any device and anywhere, thereby providing great opportunities for teleconsultation. New technologies such as the recognition of histopathology patterns using image analysis may facilitate diagnosis and improve the reproducibility among pathologists in the future.

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“…The end result is the emergence of highly efficient and sophisticated devices that can convert a pathology glass slide into a remotely available image within minutes, thereby facilitating the centralized, shared, and standardized review of slides by multiple users from various sites. 18,19,22 Automated WSI scanners are increasingly being used in many applications such as pathology education, research, quality assurance, consultation, and telepathology. 21 Technologic advancements in current WSI scanning devices have increased the capability for handling and scanning hundreds of slides automatically per day.…”

Section: Whole Slide Imaging and Its Application In Pathologymentioning

confidence: 99%

“…This initial prototype had a spatial sampling period of 0.33 microns/ pixel with the capability of scanning an entire slide in 5 to 10 minutes. [19][20][21][22] The last decade has seen a rapid emergence of vendors producing increasingly efficient and automated high-speed WSI scanners. Some contemporary WSI scanners have multislide loaders with up to 400 slides in a batch and are capable of reading bar codes on slides.…”

Section: Whole Slide Imaging and Its Application In Pathologymentioning

confidence: 99%

Central Pathology Review for Phase III Clinical Trials: The Enabling Effect of Virtual Microscopy

Mróz

Parwani

Kulesza

2013

Archives of Pathology &Amp; Laboratory Medicine

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Context.—Central pathology review (CPR) was initially designed as a quality control measure. The potential of CPR in clinical trials was recognized as early as in the 1960s and quickly became embedded as an integral part of many clinical trials since. Objective.—To review the current experience with CPR in clinical trials, to summarize current developments in virtual microscopy, and to discuss the potential advantages and disadvantages of this technology in the context of CPR. Data Sources.—A PubMed (US National Library of Medicine) search for published studies was conducted, and the relevant articles were reviewed, accompanied by the authors' experience at their practicing institution. Conclusions.—The review of the available literature strongly suggests the growing importance of CPR both in the clinical trial setting as well as in second opinion cases. However, the currently applied approach significantly impedes efficient transfer of slides and patient data. Recent advances in imaging, digital microscopy, and Internet technologies suggest that the CPR process may be dramatically streamlined in the foreseeable future to allow for better diagnosis and quality assurance than ever before. In particular, whole slide imaging may play an important role in this process and result in a substantial reduction of the overall turnaround time required for slide review at the central location. Above all, this new approach may benefit the large clinical trials organized by oncology cooperative groups, since most of those trials involve complicated logistics owing to enrollment of large number of patients at several remotely located participating institutions.

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Whole slide imaging for teleconsultation and clinical use

Cited by 21 publications

References 2 publications

Validating Whole Slide Imaging for Diagnostic Purposes in Pathology: Guideline from the College of American Pathologists Pathology and Laboratory Quality Center

Validating Whole Slide Imaging for Diagnostic Purposes in Pathology: Guideline from the College of American Pathologists Pathology and Laboratory Quality Center

Validation of Whole-Slide Imaging for Histolopathogical Diagnosis: Current State

Central Pathology Review for Phase III Clinical Trials: The Enabling Effect of Virtual Microscopy

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