Whole transcriptome sequencing reveals dexmedetomidine-improves postoperative cognitive dysfunction in rats via modulating lncRNA

Deng, Fang; Cai, Lily; Zhou, Bin; Zhou, Zhidong; Xu, Guohai

doi:10.1007/s13205-020-02190-9

Cited by 16 publications

(14 citation statements)

References 35 publications

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“…Bekker and Sturaitis [25] concluded that DEX infusion during the perioperative period signally reduced the levels of TNF-α, IL-6, and other inflammatory factors in patients. Furthermore, the results of Deng et al [26] showed that DEX could observably reduce the incidence of POCD and the levels of inflammatory factors such as IL-6 and TNF-α, which were consistent with the results of this study.…”

Section: Computational and Mathematical Methods In Medicinesupporting

confidence: 92%

Magnetic Resonance Imaging Characteristic Evaluation of Dexmedetomidine on Neurocognitive Dysfunction in Elderly Patients with Colorectal Tumors after Laparoscopic Operation

Ding

Xia

et al. 2022

Computational and Mathematical Methods in Medicine

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In order to investigate the effects of Dexmedetomidine (DEX) on postoperative anesthesia recovery time and consciousness function in elderly patients with laparoscopic colorectal tumors, 40 patients (20 in the control group and 20 in the DEX group) were selected. The DEX group was intravenously pumped at a rate of 0.8 μg/kg/h for 10 min and then continuously pumped at a rate of 0.3 μg/kg/h until 40 min before the end of the operation. The two groups were given the same amount of normal saline, with the same way of anesthesia. The results showed that the visual analog scale (VAS) score of pain in the two groups decreased signally. Compared with the control group, the inflammatory factors tumor necrosis factor (TNF-α), interleukin-1β (IL-1β), interleukin-6 (IL-6), and macrophage inflammatory protein (MIP-2) in the DEX group were remarkably decreased at T1 and T2 stages, with a considerable difference ( P < 0.05 ). One month after the auxiliary diagnosis of colorectal tumor, no clear nodular, irregular shape patches, or patchy diffuse limited points were found, which indicated that the whole tumor had been removed. In summary, DEX could improve postoperative cognitive function in elderly patients who underwent the laparoscopic radical resection of colon cancer, and its mechanism was related to the reduction of inflammatory factors. Therefore, the anesthesia intervention with DEX during the operation had a positive significance for tumor resection.

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Section: Computational and Mathematical Methods In Medicinesupporting

confidence: 92%

Magnetic Resonance Imaging Characteristic Evaluation of Dexmedetomidine on Neurocognitive Dysfunction in Elderly Patients with Colorectal Tumors after Laparoscopic Operation

Ding

Xia

et al. 2022

Computational and Mathematical Methods in Medicine

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“…In addition, it has been reported that DEX can inhibit the NF-κB pathway by regulating miR-146a-3p ( 48 ) and the TLR4 pathway via the regulation of miR-129 ( 49 ). In addition to miRNAs, lncRNAs are also involved in several diseases through DEX, such as chronic obstructive pulmonary disease ( 50 ), postoperative cognitive dysfunction ( 51 ) and oxygen-glucose deprivation/reperfusion injury ( 52 ). Thus, it may be hypothesized that miRNAs or lncRNAs could mediate the effect of DEX on TLR4/NF-κB signaling.…”

Section: Discussionmentioning

confidence: 99%

Dexmedetomidine alleviates airway hyperresponsiveness and allergic airway inflammation through the TLR4/NF‑κB signaling pathway in mice

et al. 2022

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Dexmedetomidine (DEX) suppresses inflammatory responses and protects against organ injury. The aim of the present study was to investigate the effect of DEX on airway hyperresponsiveness (AHR) and allergic airway inflammation, as well as its underlying mechanism of action in a murine model of ovalbumin (OVA)-induced asthma. A total of 30 female BALB/c mice were divided into 6 groups (n=5 mice/group): Control, OVA, OVA + DEX (20, 30 or 50 µg/kg) and OVA + TAK-242 [a toll-like receptor 4 (TLR4) inhibitor]. The mice were intraperitoneally injected with 20, 30 or 50 µg/kg DEX 1 h before OVA challenge. AHR to inhaled methacholine (Mch) was measured, and the mice were sacrificed 24 h after the last challenge. AHR following Mch inhalation was measured using the FlexiVent apparatus. Hematoxylin and eosin, periodic acid-Schiff and Wright-Giemsa staining was performed to evaluate inflammatory cell infiltration in the lung tissue. The levels of IL-4, IL-5 and IL-13 in the bronchoalveolar lavage fluid were analyzed using ELISA, and their mRNA expression levels in the lung tissue were examined using reverse transcription-quantitative PCR. The protein expression of TLR4, NF-κB and phosphorylated (p) NF-κB in the lung tissue was also detected using immunohistochemistry. In the murine OVA-induced asthma model, DEX decreased AHR following Mch inhalation and reduced the infiltration of inflammatory cells. IL-4, IL-5 and IL-13 levels in the bronchoalveolar lavage fluid were significantly lower following DEX treatment. Furthermore, DEX treatment inhibited the expression of TLR4, NF-κB and p-NF-κB in the lung tissue and exhibited a similar effect to TAK-242 treatment. In conclusion, DEX may attenuate AHR and allergic airway inflammation by inhibiting the TLR4/NF-κB pathway. These results suggested that DEX may represent a potential anti-inflammatory agent for the treatment and management of patients with asthma.

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“…LncRNAs represent an important area of research investigating the pathogenesis of POCD. Several recent studies have identified lncRNAs which are differentially expressed in POCD [ 22 – 24 ]. Among these, Chen et al demonstrated that knockdown of the lncRNA PCAI decreased cell death and degree of inflammatory response in BV-2 cells treated with lipopolysaccharide in vitro [ 25 ].…”

Section: Discussionmentioning

confidence: 99%

LncRNA NONMMUT055714 acts as the sponge of microRNA-7684-5p to protect against postoperative cognitive dysfunction

Wei

Sun

Wang

et al. 2021

Aging

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Whole transcriptome sequencing reveals dexmedetomidine-improves postoperative cognitive dysfunction in rats via modulating lncRNA

Cited by 16 publications

References 35 publications

Magnetic Resonance Imaging Characteristic Evaluation of Dexmedetomidine on Neurocognitive Dysfunction in Elderly Patients with Colorectal Tumors after Laparoscopic Operation

Magnetic Resonance Imaging Characteristic Evaluation of Dexmedetomidine on Neurocognitive Dysfunction in Elderly Patients with Colorectal Tumors after Laparoscopic Operation

Dexmedetomidine alleviates airway hyperresponsiveness and allergic airway inflammation through the TLR4/NF‑κB signaling pathway in mice

LncRNA NONMMUT055714 acts as the sponge of microRNA-7684-5p to protect against postoperative cognitive dysfunction

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