Whooping cough in a renal transplant recipient

Garbiras, M.; Shabaka, Amir; Calvo, N.; Martin, LaTasha R.; Moreno, Mauricio; Manzanara, Virginia Lopez de la; Fructuoso, Ana Sánchez

doi:10.1111/tid.12503

Cited by 3 publications

(4 citation statements)

References 33 publications

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“…To our knowledge, this is the second reported case of B pertussis infection in a renal transplant recipient and the first patient demonstrating co‐infection with B parapertussis/bronchiseptica . We considered the possibility of this case patient having a monomicrobial infection with either B parapertussis/bronchiseptica or B pertussis .…”

Section: Discussionmentioning

confidence: 81%

Bordetella pertussis in a four‐time kidney transplant recipient: A call for immunization programs at transplant centers

Hovel

Pease

Scarano

et al. 2019

Transplant Infectious Dis

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Pertussis, or whooping cough, is a highly contagious respiratory illness caused most frequently by Bordetella pertussis. Clinical presentation ranges in severity, but lifethreatening illness disproportionately affects children and immunocompromised individuals. Acellular vaccines for pertussis have been available for decades, and they are recommended throughout the lifespan. A patient who had received a kidney transplant presented with respiratory distress and dry cough as manifestations of coinfection with B pertussis and Bordetella parapertussis/bronchiseptica. The goal of this case report was to highlight the importance of immunization programs at transplant centers, which are in the unique position to care for patients both with end-stage organ disease and in the post-transplant setting. K E Y W O R D S Bordetella, immunization, kidney transplant, pneumonia, transplant | 5 of 5 HOVEL Et aL. Derrick J. Chen

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Section: Discussionmentioning

confidence: 81%

Bordetella pertussis in a four‐time kidney transplant recipient: A call for immunization programs at transplant centers

Hovel

Pease

Scarano

et al. 2019

Transplant Infectious Dis

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“…24 Six case studies reported mild to severe pertussis disease in adults aged 31-82 years with underlying conditions as Diabetes Mellitus Type II, Wegener's granulomatosis, multiple myeloma, renal transplantation, and acquired immune deficiency syndrome. [41][42][43][44][45][46] Mannose-binding lectin deficiency (MBL) One study evaluated the risk of pertussis in patients with MBL. Among study participants of all ages (median age of 15 years, age range: 1-71), severe MBL deficiency was significantly more frequent among the 125 pertussis patients than among the 430 controls (11.2% vs. 5.8%, odds ratio 2.0 [95% CI: 1.0-4.1]).…”

Section: Immunocompromising Conditionsmentioning

confidence: 99%

Pertussis in High Risk Groups: An Overview of the Past Quarter Century

Jenkins

Savic

Kandeil³

2020

Human Vaccines & Immunotherapeutics

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Infectious diseases can impact chronic medical conditions. However, it is currently not clear how pertussis correlates with preexisting or underlying disorders. We reviewed literature from the last 25 years to describe the burden and impact of pertussis infection in specific risk groups in individuals aged ≥11 years. Our literature search returned 543 hits, of which 18 were eligible for this review. Adolescents and adults with underlying conditions, such as asthma, chronic obstructive pulmonary disease (COPD), or obesity are potentially at increased risk of pertussis infection. Immunodeficiency and smoking have also been associated with worsened pertussis symptoms and an increased pertussis-related hospitalization rate. In patients with pertussis and preexisting asthma or COPD, symptoms were worsened, and healthcare costs were consequently increased. Further efforts are needed to close the knowledge gap and to understand the burden of pertussis in at-risk adolescent and adult populations to help inform vaccination strategies and recommendations.

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“…Tetanus, diphtheria, and pertussis are rare bacterial VPIs in adult SOT recipients [3][4][5][6]. In a recent cohort of SOT recipients from Switzerland, no case of diphtheria or tetanus was found within 12 years post-transplantation; however, two cases of pertussis were detected, resulting in an incidence rate of 10 per 100,000 person-years of follow-up [2].…”

Section: Introductionmentioning

confidence: 99%

“…In France, another case involved a renal transplant recipient who developed generalized tetanus 12 years post-transplantation; although anti-tetanus antibodies were detectable, the patient required prolonged intensive care and could not ingest food for 11 days due to trismus [4]. Additional reports from the USA and Spain have described pertussis infections in renal transplant recipients that were diagnosed and treated after significant delays, with patients experiencing a month of coughing [5,6]. Due to the potential risk of severe infection and poor outcomes, vaccination with tetanus and diphtheria toxoids vaccine (Td) or tetanus, diphtheria, and acellular pertussis (Tdap) vaccine are recommended in adult SOT recipients before or after transplantation [7,8].…”

Section: Introductionmentioning

confidence: 99%

Evidence for Immunity against Tetanus, Diphtheria, and Pertussis through Natural Infection or Vaccination in Adult Solid Organ Transplant Recipients: A Systematic Review

Lenzing,

Harboe,

Sørensen

et al. 2024

Microorganisms

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(1) Background: We aim to systematically review the current evidence on immunity against tetanus, diphtheria, and pertussis in adult solid organ transplantation (SOT) recipients, either through natural infection or vaccination. (2) Methods: This systematic review was conducted per PRISMA guidelines. We assessed the risk of bias using the Cochrane RoB 2 and ROBINS-I and summarized the findings narratively due to the heterogeneity of the studies. (3) Results: Of the 315 screened articles, 11 were included. Tetanus immunity varied between 55% and 86%, diphtheria immunity from 23% to 75%, and pertussis immunity was between 46% and 82%. Post-vaccination immunity showed variation across the studies, with some indicating reductions and others no change, with antibody responses influenced by transplanted organs, gender, age, and immunosuppressive regimens. The single randomized study exhibited a low risk of bias, while of the ten non-randomized studies, six showed moderate and four serious risks of bias, necessitating cautious interpretation of results. (4) Conclusions: SOT recipients exhibit considerable immunity against tetanus and diphtheria at transplantation, but this immunity decreases over time. Although vaccination can enhance this immunity, the response may be suboptimal, and the increased antibody levels may not persist, underscoring the need for tailored vaccination strategies in this vulnerable population.

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Whooping cough in a renal transplant recipient

Cited by 3 publications

References 33 publications

Bordetella pertussis in a four‐time kidney transplant recipient: A call for immunization programs at transplant centers

Bordetella pertussis in a four‐time kidney transplant recipient: A call for immunization programs at transplant centers

Pertussis in High Risk Groups: An Overview of the Past Quarter Century

Evidence for Immunity against Tetanus, Diphtheria, and Pertussis through Natural Infection or Vaccination in Adult Solid Organ Transplant Recipients: A Systematic Review

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