Why And How Indo-mediterranean Diet, May Be Superior To Other Diets? The Role Of Antioxidants In The Diets

Singh, Ram B.; Fatima, Ghizal; Fedačko, Ján; Magamadov, Aminat; Watanabe, Shaw

doi:10.20944/preprints202201.0373.v1

Cited by 13 publications

(1 citation statement)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is not only time of eating but also frequency of eating as well as content of foods and also possibly mastication of foods which can influence the risk of CVDs and T2DM [35][36][37][38][39]. It seems that eating moderate amount of Indo-Mediterranean foods as breakfast, may be crucial for prevention of CVDs and T2DM as well as all-cause mortality, because such foods are considered to be potential immune-modulators [40,41].…”

Section: International Breakfast Research Initiative Recommendationsmentioning

confidence: 99%

Effects of Breakfast Skipping on The Risk of Cardiovascular Diseases and Diabetes Mellitus

Singh¹,

Fedačko²,

Fatima³

et al. 2022

Preprint

View full text Add to dashboard Cite

Epidemiological studies indicate that skipping breakfast as a universal behavior, may have adverse effects on cardiovascular diseases [CVDs}and metabolic diseases. However, eating breakfast regularly, may increase satiety, thereby reducing overeating later in the day which prevents weight gain. Recent studies indicate that skipping breakfast increases the risk of obesity, metabolic syndrome, hypertension, hypercholesterolemia, type 2 diabetes mellitus (T2DM), coronary artery disease (CAD), and cardiovascular mortality as well as all-cause mortality. However, many studies also reported that regular taking of breakfast decreases the risk of CVDs and T2DM and all-cause mortality. Previous studies reported that heavy breakfast, in particular eating western diet may increase circadian rhythm of CVDs and sudden cardiac death. It seems that those who do not eat breakfast, they tend to eat refined and sweetened products, possibly, more in the night resulting in to greater risk of CVDs and T2DM. Breakfast skipping and eating in the night, may be associated with circadian misalignment in the central and peripheral clocks, leading to oxidative stress and inflammation. Increased systemic inflammation damages the adipocytes, beta cells of pancreas, endothelial cells and smooth muscle cells as well as neurons, which may produce dysfunction in these cells resulting in to related diseases. The beneficial effects of breakfast, may also be, at least in part, due to nutrient dense foods rather than time of eating. Eating regular breakfast, in particular rich in Indo-Mediterranean foods; vegetables, whole grains, fruits, spices and nuts may be protective against circadian increase in oxidative stress in the morning, resulting in to significant decline in the risk of CVDs and T2DM.

show abstract

Section: International Breakfast Research Initiative Recommendationsmentioning

confidence: 99%

Effects of Breakfast Skipping on The Risk of Cardiovascular Diseases and Diabetes Mellitus

Singh¹,

Fedačko²,

Fatima³

et al. 2022

Preprint

View full text Add to dashboard Cite

show abstract

Plasma Carotenoids and Polyphenols and Their Association with MetS: The Need for Nutritional Interventions

et al. 2023

View full text Add to dashboard Cite

Metabolic syndrome (MetS) is characterized by increased pro-oxidative stress and a chronic inflammation state and their consequent alterations. Several studies have highlighted the protective effect of carotenoids and polyphenols in MetS patients. This study aimed to evaluate the plasma level of selected carotenoids and polyphenols and to determine their relationship with MetS severity, MetS components, and inflammatory markers in Polish adults with metabolic disorders. It was designed as a cross-sectional study. The final study group comprised 275 adults, including 158 women and 117 men. Data were collected on the frequency of consumption of selected food groups. Anthropometric measurements and blood samples were taken to determine the concentration of carotenoids, polyphenols, and indicators (parameters) of metabolic disorders. Plasma concentrations of selected carotenoids and polyphenols were low in adults with MetS. The highest concentrations of carotenoids and polyphenols in the blood were observed for lutein and phenolic acids (including gallic and p-coumaric acids). Nevertheless, a correlation was found between the individual bioactive compounds and MetS components. In terms of the lipid profile, our study showed that the plasma of the selected carotenoids and polyphenols positively correlated with HDL cholesterol (zeaxanthin; total carotenoids), LDL cholesterol (chlorogenic acid), triglycerides (lycopene), and the total cholesterol (kaempferol). We found that the level of CRP as a marker of inflammation negatively correlated with the concentration of zeaxanthin. In our study group, no relationship was found between the dietary antioxidant intensity and the variables studied, which may be attributed to the low frequency of consumption of the sources of bioactive compounds, such as carotenoids and polyphenols, but also to the metabolic disorders. Further research is needed to determine whether these associations are causally related to the metabolic syndrome or are a result of the pathologies of the syndrome or improper diet with a low intake of vegetables and fruit.

show abstract

Paneth Cell, Gut Microbiota Dysbiosis and Diabetes Mellitus

Luvhengo,

Mabasa,

Molepo

et al. 2023

Applied Sciences

View full text Add to dashboard Cite

Around 500 million adults in the world have diabetes mellitus, and the incidence is increasing. Over 90% of type 2 diabetes mellitus cases are associated with dysbiosis of the microbiota of the gut, chronic systemic inflammation, mitochondrial dysfunction and destruction of the β-cells of the pancreas. Paneth cells are found in the entire length of the small intestine in humans and play a key role in its innate immunity. Deficient function of Paneth cells predisposes the intestine to gastrointestinal and extra-gastrointestinal diseases, which include inflammatory bowel disease. This manuscript reviews the roles of the Paneth cells in the innate immunity of the small intestine, the link between dysbiosis and dysfunction of Paneth cells and the influence of dysbiosis in the pathogenesis of diabetes mellitus. The manuscript also reviews some strategies currently used to try to reverse dysbiosis and its consequences.

show abstract

Why And How Indo-mediterranean Diet, May Be Superior To Other Diets? The Role Of Antioxidants In The Diets

Cited by 13 publications

References 28 publications

Effects of Breakfast Skipping on The Risk of Cardiovascular Diseases and Diabetes Mellitus

Effects of Breakfast Skipping on The Risk of Cardiovascular Diseases and Diabetes Mellitus

Plasma Carotenoids and Polyphenols and Their Association with MetS: The Need for Nutritional Interventions

Paneth Cell, Gut Microbiota Dysbiosis and Diabetes Mellitus

Contact Info

Product

Resources

About