2015
DOI: 10.1021/acs.iecr.5b01667
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Why Are Two Enzymes Better than One for the Efficient Simultaneous Saccharification and Fermentation (SSF) of Natural Polymers? Hints from Inside and Outside a Yeast

Abstract: In the Simultaneous Saccharification and Fermentation (SSF) of natural polymers, in addition to regulating the intracellular enzymes for metabolizing the nutrients, the excretion and synthesis of extracellular depolymerases for the breakdown of the polymeric substrates must be regulated by the microbes accordingly. Through a case study of the growth of a recombinant Saccharomyces cerevisiae capable of excreting both α-amylase and glucoamylase on starch, we demonstrated that the interlinked population balance a… Show more

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Cited by 7 publications
(3 citation statements)
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“…These unstructured models are often unable to provide a mechanistic understanding of coupled multi‐physics phenomena in cellulose bioconversion, including SSF and CBP. By contrast, Ho et al (2015a, 2015b) made a significant step forward in this regard by accounting for the coupled dynamics of polymeric saccharification and regulation of cellular metabolism during fermentation by interlinking population balances and cybernetic models. Despite improved predictions compared to existing approaches, this model still has limited capability of providing mechanistic details due to: (1) oversimplification of fermentation pathways into a single‐step reaction and (2) lack of consideration of extensive recalcitrance through heterogeneous structure and properties of cellulose.…”
Section: Introductionmentioning
confidence: 99%
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“…These unstructured models are often unable to provide a mechanistic understanding of coupled multi‐physics phenomena in cellulose bioconversion, including SSF and CBP. By contrast, Ho et al (2015a, 2015b) made a significant step forward in this regard by accounting for the coupled dynamics of polymeric saccharification and regulation of cellular metabolism during fermentation by interlinking population balances and cybernetic models. Despite improved predictions compared to existing approaches, this model still has limited capability of providing mechanistic details due to: (1) oversimplification of fermentation pathways into a single‐step reaction and (2) lack of consideration of extensive recalcitrance through heterogeneous structure and properties of cellulose.…”
Section: Introductionmentioning
confidence: 99%
“…These unstructured models are often unable to provide a mechanistic understanding of coupled multi-physics phenomena in cellulose bioconversion, including SSF and CBP. By contrast, Ho et al (2015aHo et al ( , 2015b) made a significant step forward in this regard by accounting for the coupled dynamics of polymeric saccharification and regulation of cellular metabolism during fermentation by interlinking population balances and cybernetic models.…”
mentioning
confidence: 99%
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