Why Candida Species have Emerged as Important Nosocomial Pathogens?

Deorukhkar, Sachin Chandrakant; Saini, Santosh

doi:10.20546/ijcmas.2016.501.054

Cited by 14 publications

(15 citation statements)

References 37 publications

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“…It is reported that 25% of urinary tract infections were related to Candida spp. [ 7 ]. 50 to 75% of women of childbearing age developed vulvovaginal candidiasis annually and 5 to 8%, or about 75 million women, can be affected at least four times in a year [ 8 – 10 ].…”

Section: Introductionmentioning

confidence: 99%

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Ethnobotanical survey on plants used in the treatment of candidiasis in traditional markets of southern Benin

Fanou

Klotoé

Fah

et al. 2020

BMC Complement Med Ther

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Background Candidiasis, an opportunistic cosmopolitan disease is nowadays like bacterial infections which is a real public health problem. In view of the emergence of Candida strains resistant to existing antifungal agents, alternative solutions should be considered. This is the purpose of this ethnobotanical survey, which aims to identify the medicinal plant species traditionally used to treat candidiasis in traditional markets of southern Benin. Methods The study was performed from October 2015 to January 2018 in the traditional markets of Southern-Benin. Data were collected by two complementary methods: triplet purchase of medicinal recipes (ATRM) from herbalists markets and semi-structured interview (ISS) from traditional healers. Results A total of 109 species of medicinal plants belonging to 44 families have been listed and identified. The most frequently cited species were Pteleopsis suberosa Engl. & Diels, Lantana camara L., Cyanthillium cinereum (L.) H. Rob, Ocimum gratissimum L. and Lippia multiflora Moldenke with respectively 43.84, 39.73 and 34.25% citation frequencies for the last three species respectively. Leguminosae (20.18%), Euphorbiaceae (5.50%) and Apocynaceae (5.50%) were the most represented botanical families. Leafy stems were more used than other plant organs. The decoction and the oral route were the most appropriate methods of preparation and administration reported by traditional healers. Conclusion Benin’s plant cover is made up of a wide variety of medicinal plant species used in the traditionnal treatment of candidiasis and which may constitute new sources of medicines to be developed.

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Section: Introductionmentioning

confidence: 99%

“…Their therapeutic management requires the use of antifungals to which Candida spp. strains are increasingly resistant [ 7 , 18 , 19 ]. Indeed, high levels of Candida spp .…”

Section: Introductionmentioning

confidence: 99%

Ethnobotanical survey on plants used in the treatment of candidiasis in traditional markets of southern Benin

Fanou

Klotoé

Fah

et al. 2020

BMC Complement Med Ther

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“…While a large number of microorganisms are capable of causing infections, those that are able to survive and thrive in clean sites, such as that of clinics and hospitals, present a considerable threat [ 57 ]. These organisms include Gram-positive Enterococcus faecalis , Candida albicans , Staphylococcus aureus , Staphylococcus epidermidis , and Streptococcus viridans ; and Gram-negative Escherichia coli , Klebsiella pneumoniae , Proteus mirabilis , and Pseudomonas aeruginosa .…”

Section: Microbial Contaminationmentioning

confidence: 99%

Plant Secondary Metabolite-Derived Polymers: A Potential Approach to Develop Antimicrobial Films

et al. 2018

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The persistent issue of bacterial and fungal colonization of artificial implantable materials and the decreasing efficacy of conventional systemic antibiotics used to treat implant-associated infections has led to the development of a wide range of antifouling and antibacterial strategies. This article reviews one such strategy where inherently biologically active renewable resources, i.e., plant secondary metabolites (PSMs) and their naturally occurring combinations (i.e., essential oils) are used for surface functionalization and synthesis of polymer thin films. With a distinct mode of antibacterial activity, broad spectrum of action, and diversity of available chemistries, plant secondary metabolites present an attractive alternative to conventional antibiotics. However, their conversion from liquid to solid phase without a significant loss of activity is not trivial. Using selected examples, this article shows how plasma techniques provide a sufficiently flexible and chemically reactive environment to enable the synthesis of biologically-active polymer coatings from volatile renewable resources.

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“…Due to their versatility of adapting to a variety of different habitats including medical devices, Candida spp. have emerged as one of the important causes of health-care associated infections [14]. Candida rank 3rd among leading causes of catheter-associated infections [15].…”

Section: Biofilm Formationmentioning

confidence: 99%

Virulence Traits Contributing to Pathogenicity of Candida Species

Deorukhkar¹

2017

JMEN

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Candida is the unique opportunistic mycotic pathogen that has adapted variety of mechanisms to establish itself both as commensal and pathogen in humans. This yeast like fungus presents in many clinical forms, ranging from superficial manifestations involving the skin, nails and mucosal surfaces to deep seated infections involving various internal organs and disseminated diseases. Although Candida spp. can initiate infection in both immunocompetent and immunocompromised hosts, the incidence of candidiasis is usually high in immunocompromised patients. Therefore the role of Candida in overall process of initiation and progression of infection was considered to be passive. However, recently this concept is revamped and it can be now stated that Candida actively participates in the pathophysiology of establishment and progression of infection through the mechanisms of aggression known as virulence factors. Some of these virulence factors help in colonization or initiation of infection while others aid in progression of infection or dissemination in host tissues. Adherence to host tissues, biofilm formation on medical devices and secretion of ectohydrolases are some of putative virulence traits of Candida spp. Although virulence factors contributing to pathogenicity of Candida albicans is well studied, the search through available literature has revealed a dearth of information on virulence factors of non albicans Candida (NAC) spp. The identification of virulence attributes unique to a particular Candida spp. is very important to understand the pathogenesis and epidemiology of candidiasis.

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Why Candida Species have Emerged as Important Nosocomial Pathogens?

Cited by 14 publications

References 37 publications

Ethnobotanical survey on plants used in the treatment of candidiasis in traditional markets of southern Benin

Ethnobotanical survey on plants used in the treatment of candidiasis in traditional markets of southern Benin

Plant Secondary Metabolite-Derived Polymers: A Potential Approach to Develop Antimicrobial Films

Virulence Traits Contributing to Pathogenicity of Candida Species

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