Why Do Older Women Have Poor Implantation Rates? A Possible Role of the Mitochondria

Bartmann, Ana Karina; Romão, Gustavo Salata; Ramos, Ester Silveira; Ferriani, Rui Alberto

doi:10.1023/b:jarg.0000027018.02425.15

Cited by 60 publications

(43 citation statements)

References 33 publications

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“…The same mechanism has been postulated to play a role in the ageing of human oocytes [143][144][145][146][147][148][149]. Considering that human oocytes enter the first stage of meiosis during fetal life and then arrest until later in adult life, when they are selected for further development via folliculogenesis, this long period of quiescence might be responsible for the sustained exposure of the oocyte in general and its mitochondria in particular to ROS, with the resultant compromise in the capacity of the oocyte to finish the process of meiosis competently [150].…”

Section: Menopausementioning

confidence: 75%

Reproductive ageing in women

Djahanbakhch

Ezzati

Zosmer

2007

The Journal of Pathology

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The traditional view in respect to female reproduction is that the number of oocytes at birth is fixed and continuously declines towards the point when no more oocytes are available after menopause. In this review we briefly discuss the embryonic development of female germ cells and ovarian follicles. The ontogeny of the hypothalamic-pituitary-gonadal axis is then discussed, with a focus on pubertal transition and normal ovulatory menstrual cycles during female adult life. Biochemical markers of menopausal transition are briefly examined. We also examine the effects of age on female fertility, the contribution of chromosomal abnormalities of the oocyte to the observed decline in female fertility with age and the possible biological basis for the occurrence of such abnormalities. Finally, we consider the effects of maternal age on obstetric complications and perinatal outcome. New data that have the potential to revolutionize our understanding of mammalian oogenesis and follicular formation, and of the female reproductive ageing process, are also briefly considered.

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Section: Menopausementioning

confidence: 75%

Reproductive ageing in women

Djahanbakhch

Ezzati

Zosmer

2007

The Journal of Pathology

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“…These include impaired mitochondrial function, genomic instability, and oxidative stress. Therefore, it is possible that as women and oocytes age and the mitochondrial energy production decreases, that many of the processes of oocyte maturation, especially nuclear spindle activity and chromosomal segregation, become impaired [9,10]. The result is the increased rate of aneuploidy, especially trisomies observed in older women.…”

Section: Discussionmentioning

confidence: 99%

The effect of age on in vitro fertilization outcome: is too young possible?

Nazemian

Esfandiari

Javed

et al. 2010

J Assist Reprod Genet

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Purpose The negative correlation between fecundity and age in women has been extensively documented although data on reproductive performance in very young women is sparse. The objective of this study was to determine whether age ≤25 years has an impact on reproductive outcome in women undergoing IVF-ET. Methods IVF outcome in 85 infertility patients aged 19-25 years was compared to that in 69 infertility patients aged 30-35 years. Primary outcomes included fertilization rates and embryo quality. Secondary outcomes were clinical pregnancy and miscarriage rates. Results The young patients (≤25 years) demonstrated a lower fertilization rate, and reduced number of top quality embryos. Although clinical pregnancy, and implantation rates were similar to their older counterparts (30-35 years), the young women had a significantly higher miscarriage rate. Conclusion Our results demonstrating poorer reproductive performance in very young patients were surprising and need further investigation.

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“…Ubiquitous mitochondrial %O 2 K production is the first step in the formation and propagation of ROS within and out of the cell and it could be a mediator of oxidative chain reactions that alter cell function and integrity (Orrenius et al 2007). Abnormal mitochondrial activity alters ROS production and reduces conceptus implantation in women (Bartmann et al 2004). Therefore, Figure 7 Representative immunohistochemical localisation of tryptophanyl tRNA synthetase (WARS) in the sheep aglandular caruncular (left panels) and glandular intercaruncular (right panels) collected from cyclic ewes on days 12, (C12) and 16 (C16) of the oestrous cycle and on days 12, (P12) and 16 (P16) of pregnancy.…”

Section: Antioxidant Cell Defencementioning

confidence: 99%

Proteomic analysis of the sheep caruncular and intercaruncular endometrium reveals changes in functional proteins crucial for the establishment of pregnancy

Al-Gubory¹,

Arianmanesh²,

Garrel³

et al. 2014

Reproduction

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The expression and regulation of endometrial proteins are crucial for conceptus implantation and development. However, little is known about site-specific proteome profiles of the mammalian endometrium during the peri-implantation period. We utilised a two-dimensional gel electrophoresis/mass spectrometry-based proteomics approach to compare and identify differentially expressed proteins in sheep endometrium. Caruncular and intercaruncular endometrium were collected on days 12 (C12) and 16 (C16) of the oestrous cycle and at three stages of pregnancy corresponding to conceptus pre-attachment (P12), implantation (P16) and post-implantation (P20). Abundance and localisation changes in differentially expressed proteins were determined by western blot and immunohistochemistry. In caruncular endometrium, 45 protein spots (5% of total spots) altered between day 12 of pregnancy (P12) and P16 while 85 protein spots (10% of total spots) were differentially expressed between P16 and C16. In intercaruncular endometrium, 31 protein spots (2% of total spots) were different between P12 and P16 while 44 protein spots (4% of total spots) showed differential expression between C12 and C16. The pattern of protein changes between caruncle and intercaruncle sites was markedly different. Among the protein spots with implantation-related changes in volume, 11 proteins in the caruncular endometrium and six proteins in the intercaruncular endometrium, with different functions such as protein synthesis and degradation, antioxidant defence, cell structural integrity, adhesion and signal transduction, were identified. Our findings highlight the different but important roles of the caruncular and intercaruncular proteins during early pregnancy.

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Why Do Older Women Have Poor Implantation Rates? A Possible Role of the Mitochondria

Cited by 60 publications

References 33 publications

Reproductive ageing in women

Reproductive ageing in women

The effect of age on in vitro fertilization outcome: is too young possible?

Proteomic analysis of the sheep caruncular and intercaruncular endometrium reveals changes in functional proteins crucial for the establishment of pregnancy

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