Why Do Our Kidneys Get Old

Wiggins, Jocelyn

doi:10.1159/000328008

Cited by 9 publications

(3 citation statements)

References 67 publications

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“…The kidney is also highly vascular and is impacted by aging of the vascular system with respect to the development of atherosclerosis and hypertension. It has been known for over 50 years that renal functions decline with age, and glomerulosclerosis increases with age even in the absence of comorbidities 19. Females develop lower levels of age-dependent renal function loss than males, which may be in part due to the protective effects of estrogen on cardiorenal function.…”

Section: Discussionmentioning

confidence: 99%

Oxidative damage parameters in renal tissues of aged and young rats based on gender

Uzun¹,

Korkmaz²,

Sitar³

et al. 2013

CIA

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PurposeAging is characterized by a gradual functional decrease of all systems including the kidneys. Growing evidence links altered lipid protein redox-homeostasis with renal dysfunction. The effect of sexual dimorphism on the lipid protein redox-homeostasis mechanisms in the aging kidney is obscure. In the current study, we aimed to investigate redox homeostasis as it related to sexual dimorphism on protein oxidation and lipid peroxidation parameters, as protein carbonyl (PCO), total thiol (T-SH), advanced oxidation protein products (AOPP), malondialdehyde, glutathione (GSH), and superoxide dismutase (SOD) activity, as potential aging biomarkers, which may contribute to an analysis of the free radical theory of aging.Materials and methodsThe study was carried out with 16 naturally aged rats (24 months old; eight males and eight females) and their corresponding young rat groups as controls (6 months old; eight males and eight females). All of the aforementioned parameters (PCO, T-SH, AOPP, MDA, GSH, SOD) were measured manually instead of automated devices or ELISA kits.ResultsPCO, AOPP, and malondialdehyde levels in aged rats were significantly higher in the older rat group than in the younger rat group, whereas SOD activities were significantly lower in old rats. T-SH levels were not significantly different in male groups; however, T-SH levels were lower in the aged female group than in the young female control group. In addition, GSH levels were significantly different between the aged rat group and the corresponding young control group for both genders.ConclusionWith respect to PCO and AOPP, impaired redox homeostasis is substantially more prominent in males than females. The decrease of G-SH levels in male groups could be attributed to stabilizing the redox status of protein thiol groups by the depletion of the GSH groups. Considering the results, the renal tissue proteins and lipids in different genders may have different susceptibilities to oxidative damage.

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Section: Discussionmentioning

confidence: 99%

Oxidative damage parameters in renal tissues of aged and young rats based on gender

Uzun¹,

Korkmaz²,

Sitar³

et al. 2013

CIA

View full text Add to dashboard Cite

show abstract

“…Research in aging is a young field and aging has turned out to be a complex process controlled by many transcription factors and signaling pathways. 7 Although aging seems to occur in most species, many animals living in the natural environment do not become senescent because they die of disease, starvation, and predation before they reach old age. 8,9 Even so, the phenomenon of negligible senescence, which is characterized by an attenuated age-related change in reproductive and physiologic functions, as well as no observable agerelated gradual increase in mortality rate, 9 has been documented.…”

Section: The Biological Process Of Agingmentioning

confidence: 99%

Chronic Kidney Disease: A Clinical Model of Premature Aging

Stenvinkel

Larsson

2013

American Journal of Kidney Diseases

256

209

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“…With aging, there are changes concerning nutritional habits, leading to alterations of the gastrointestinal system, leading to improper digestion [20]. The geriatric population has decreased renal function as well [21,22]. A decline in the endocrine function of the pineal gland and sex hormones leads to their diminished protective effects and changes the individual`s adaptive capabilities [23][24][25].…”

Section: Specifics Of Geriatric Populationmentioning

confidence: 99%

Hip Fractures in a Geriatric Population - Rehabilitation Based on Patients Needs

Radosavljevic¹,

Nikolić

Lazović³

et al. 2014

aging dis

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With an increased life expectancy in humans and thus an increase in the number of the elderly population, the frequency of hip fractures will rise as well. Aside from a higher incidence, hip fractures in a geriatric population is a significant problem due to the possible onset of severe and in some cases dramatic complications and consequences. The primary purpose of treatment and rehabilitation in the elderly after a hip fracture is to improve an individual's quality of life. It is important to underline that principles and methods of functional restoration after hip fracture should consider careful planning of a rehabilitation program individually for every patient and its implementation with respect to decisions made by the rehabilitation team.

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Why Do Our Kidneys Get Old

Cited by 9 publications

References 67 publications

Oxidative damage parameters in renal tissues of aged and young rats based on gender

Oxidative damage parameters in renal tissues of aged and young rats based on gender

Chronic Kidney Disease: A Clinical Model of Premature Aging

Hip Fractures in a Geriatric Population - Rehabilitation Based on Patients Needs

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