Why do people take part in vaccine trials? A mixed methods narrative synthesis

Dean, Alfred; Rose, F. Clifford; Jones, Katherine; Scantlebury, Arabella; Adamson, Joy; Knapp, Peter

doi:10.1016/j.pec.2023.107861

Cited by 2 publications

(5 citation statements)

References 59 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Patient-centric also means designing trials that are realistic and easy to implement. Complex protocols, even basic RCT requirements such as randomization and blinding, may be disincentivizing ( 13 , 24 ). A Cochrane meta-analysis of research into methods and factors in clinical trial recruitment found high evidence that recruitment efforts were 10% more successful for open trials compared with blinded, placebo-controlled ( 32 ).…”

Section: Patient-centric Designmentioning

confidence: 99%

“…Surveys show that, in general, patients regard clinical trials as essential to medical progress and want to participate in them (7,8). It also indicates that clinical trial participants are chiefly motivated by the desire to help others, personal benefit, and the perception that they are a good fit for the study (and vice-versa) (8)(9)(10)(11)(12)(13)(14)(15). Patients are often influenced by close relationships when facing a decision to participate in a clinical trial.…”

Section: Participant Motivationmentioning

confidence: 99%

“…Mistrust in clinical trials is commonplace, particularly among individuals with negative medical experiences and among groups (e.g., African-American, Latinx, and other racial and ethnic minorities) who have historically experienced medical discrimination and exploitation (7,(27)(28)(29)(30). Mistrust in clinical research is often multifactorial, may be conscious or subconscious, and may be reinforced by beliefs, attitudes, and messages among peers, family members, social and mainstream media, and other community members, sometimes including, unfortunately, healthcare providers (13,15,24,27). Facing a decision around trial participation, patients may host an array of concerns, including how they will be treated, what will happen to their specimens and their data, whether or not their contributions will be appreciated, and whether they are being coerced, whether information about risks of participation is being withheld (13,27,29).…”

Section: Recruitment Barriersmentioning

confidence: 99%

“…Mistrust in clinical research is often multifactorial, may be conscious or subconscious, and may be reinforced by beliefs, attitudes, and messages among peers, family members, social and mainstream media, and other community members, sometimes including, unfortunately, healthcare providers ( 13 , 15 , 24 , 27 ). Facing a decision around trial participation, patients may host an array of concerns, including how they will be treated, what will happen to their specimens and their data, whether or not their contributions will be appreciated, and whether they are being coerced, whether information about risks of participation is being withheld ( 13 , 27 , 29 ). Many or all of the patients' concerns may go unexpressed.…”

Section: Introductionmentioning

confidence: 99%

“…It is critical that researchers and recruiters invite potential participants to share their questions and concerns, provide information as appropriate, and help them sort through ambivalence ( 13 ). Doubts and questions that go unaddressed allow mistrust to linger and interfere with recruitment.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Recruitment and retention of clinical trial participants: understanding motivations of patients with chronic pain and other populations

Anastasi,

Capili,

Norton

et al. 2024

Front. Pain Res.

View full text Add to dashboard Cite

This paper aims to present and discuss the issues, challenges, and strategies related to recruitment and retention in clinical trials involving participants with chronic pain. The randomized controlled clinical trial (RCT) is widely regarded as the gold standard for evaluating clinical interventions. However, it is crucial to acknowledge and address the challenges associated with recruiting and retaining participants. To prioritize the experience of the study population, targeted outreach strategies and a patient-centric approach are necessary. Researchers should consider incorporating recruitment and retention strategies during the study design phase. Implementing multi-pronged recruitment methods, leveraging relationships with community providers, and involving representatives of the patient population are helpful approaches. Effective communication and maintaining a professional environment are vital for optimizing engagement and supporting the successful execution of clinical trials involving participants with chronic pain.

show abstract

Section: Patient-centric Designmentioning

confidence: 99%

Section: Participant Motivationmentioning

confidence: 99%

Section: Recruitment Barriersmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Recruitment and retention of clinical trial participants: understanding motivations of patients with chronic pain and other populations

Anastasi,

Capili,

Norton

et al. 2024

Front. Pain Res.

View full text Add to dashboard Cite

show abstract

Factors that influence recruitment to COVID-19 vaccine trials: a qualitative evidence synthesis

Biesty,

Sheehan,

Meskell

et al. 2024

Trials

View full text Add to dashboard Cite

Background The COVID-19 pandemic marked a unique period characterised by an extraordinary global virus spread. The collective effort to halt the transmission of the virus led to various public health initiatives, including a variety of COVID-19 vaccine trials. Many of these trials used adaptive methods to address the pandemic’s challenges, such as the need for rapid recruitment. These adaptive methods allow for modifications to the trial procedures without undermining the trial’s integrity, making the research process more flexible and efficient. However, recruiting participants for vaccine trials remains a considerable challenge. The aim of this qualitative evidence synthesis (QES) is to explore the factors that influence a person’s decision to participate in a COVID-19 vaccine trial. Lessons learned from this could help shape future trials’ design and conduct, particularly those conducted within a pandemic. Methods We conducted a systematic search for qualitative studies and mixed methods studies with a qualitative component in the WHO COVID-19 Research Database, MEDLINE, CINAHL, PsycINFO, Epistemomikos, Online Resource for Research in Clinical Trials (ORCCA), and the Cochrane COVID-19 Study Register. We used the best-fit framework synthesis approach and the Social Ecological Model as an a priori framework. We used the GRADE-CERQual approach to assess our confidence in the review findings. Results Five studies involving 539 participants were included. One of these studies included participants in a COVID-19 vaccine trial. In three of the studies, participants were asked hypothetically about their attitudes. Another study included people who had either not responded to or declined an invitation to participate in a COVID-19 vaccine trial. We developed six themes outlining the factors that influence a person’s decision to participate in a COVID-19 vaccine trial: (1) personal gains, (2) perceived risk, (3) influence of family and community, (4) contributing for others, (5) institutional trust and mistrust, and (6) accessibility of the trial. Conclusion This review sheds light on how people perceive the potential personal, family, and community advantages of trial participation and how these perceptions may be weighed against concerns about vaccine safety. The findings also point toward specific aspects of trial methodology to consider when designing COVID-19 vaccine trials. Graphical Abstract Supplementary Information The online version contains supplementary material available at 10.1186/s13063-024-08670-0.

show abstract

Why do people take part in vaccine trials? A mixed methods narrative synthesis

Cited by 2 publications

References 59 publications

Recruitment and retention of clinical trial participants: understanding motivations of patients with chronic pain and other populations

Recruitment and retention of clinical trial participants: understanding motivations of patients with chronic pain and other populations

Factors that influence recruitment to COVID-19 vaccine trials: a qualitative evidence synthesis

Contact Info

Product

Resources

About