Why do we need chemical derivatization?

Holländer, Andreas

doi:10.1002/ppap.201700044

Cited by 7 publications

(2 citation statements)

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“…Chemical derivatization involves the conversion of a compound (educt) into a product with a more favorable chemical structure, the derivative. Already in the 19th century, the approach was exploited in organic synthesis [ 7 ]. In general, a specific functional group of an organic compound participates in the derivatization reaction, which converts the educt into a derivative of a different chemical composition, thus modifying reactivity, solubility, boiling/melting points, or the aggregation state.…”

Section: Chemical Derivatizationmentioning

confidence: 99%

Chemical Derivatization in Flow Analysis

Rocha

Zagatto

2022

Molecules

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Chemical derivatization for improving selectivity and/or sensitivity is a common practice in analytical chemistry. It is particularly attractive in flow analysis in view of its highly reproducible reagent addition(s) and controlled timing. Then, measurements without attaining the steady state, kinetic discrimination, exploitation of unstable reagents and/or products, as well as strategies compliant with Green Analytical Chemistry, have been efficiently exploited. Flow-based chemical derivatization has been accomplished by different approaches, most involving flow and manifold programming. Solid-phase reagents, novel strategies for sample insertion and reagent addition, as well as to increase sample residence time have been also exploited. However, the required alterations in flow rates and/or manifold geometry may lead to spurious signals (e.g., Schlieren effect) resulting in distorted peaks and a noisy/drifty baseline. These anomalies can be circumvented by a proper flow system design. In this review, these aspects are critically discussed mostly in relation to spectrophotometric and luminometric detection.

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Section: Chemical Derivatizationmentioning

confidence: 99%

Chemical Derivatization in Flow Analysis

Rocha

Zagatto

2022

Molecules

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“…This problem was considered from a wider perspective by Andreas Hollaender who, in his recent comments, raised insightful questions like “ why do we need chemical derivatization at all ” and “ what do we actually want to know? ” A fundamental urge to reveal the truth drives scientists to search for new approaches (typically more complex, more sophisticated and, to be honest, more expensive). It is true that the use of combined approaches, such as FTIR‐ATR with H/D isotope exchange, and NEXAFS allowed some light to be shed on the problem of distinguishing the N‐bearing functional groups on plasma‐treated polymer surfaces .…”

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confidence: 99%