Gay neighborhoods, like all neighborhoods, are in a state of continual change. The relevance of gay neighborhoods—originally formed to promote segregation of individuals who identify as sexual minorities—is lately challenged by advances in technology, experiences with pandemics, shifts in generational opinion and social values, increasing acceptance of LGBTQ+ individuals, and (in certain places) increased rights and protections for LGBTQ+ individuals. This confluence of change has created for many people anxiety related to the belief that gay neighborhoods may be dissolving or even disappearing altogether. Seeking to address these concerns, this opening chapter of the book The Life and Afterlife of Gay Neighborhoods: Renaissance and Resurgence presents eight important takeaway messages distilled from the chapters in this volume that, taken together, provide an in-depth overview of the formation, maturation, current challenges, and future prospects of LGBTQ+ spaces in urban environments. Findings suggest that shifts in patterns of residence, socialization, and entertainment for LGBTQ+ residents and visitors across metropolitan space have resulted in certain gay neighborhoods becoming less gay while other neighborhoods become more gay. In this time of social change, economic inequities, public health crises, and technological evolution, gay neighborhoods provide a culturally and historically significant template for communities in confronting adversity, fear, and discrimination. At this point in their maturity, gay neighborhoods have reached a plateau in their evolution; from here we pause to consider the current state of gay neighborhoods—and trajectories that might describe their future form—as we contemplate the importance of gay neighborhoods in the ongoing advancement of LGBTQ+ people everywhere. We conclude by observing that while gayborhoods have experienced a certain level of de-gaying, the trend toward viewing gayborhoods as inclusive and gay-friendly places de-emphasizes the self-segregation aspects of gayborhoods that were important to their initial formation; consequently, while gay neighborhoods may become less gay, other neighborhoods may also become more gay.