2018
DOI: 10.1101/377226
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Why is cancer not more common? A changing microenvironment may help to explain why, and suggests strategies for anti-cancer therapy

Abstract: AbstractOne of the great unsolved puzzles in cancer biology is not why cancers occur, but rather, explaining why so few cancers occur compared with the theoretical number that could occur given the number of progenitor cells in the body and the normal mutation rate. We hypothesised that a contributory explanation is that the tumour microenvironment (TME) is not fixed, and that this could impair the ability of neoplastic cells to retain a high enough fitness to become a cancer. … Show more

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