Why is cancer so common a disease in people yet so rare at a cellular level?

Ferrell, Stuart D.; Ahmad, I.; Nguyen, Christine L.; Petrova, Sarah C.; Wilhelm, Sabrina R.; Yin, Yulong; Barsky, Sanford H.

doi:10.1016/j.mehy.2020.110171

Cited by 4 publications

(3 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Breast cancer has become one of the diseases with a high mortality rate. [8]. Since the new cancer treatment that has a selective treatment effects and low required to improve patient quality life.…”

Section: Discussionmentioning

confidence: 99%

Histopathological Effect of Annona Muricata Fruit Extract on Methyl nitrosourea -Induced Mammary Gland Carcinoma in Female Albino Mice

Sabah Abdulhur,

Hamza Fares

2023

Kufa Jou. Vete. Med. Sci.

View full text Add to dashboard Cite

The Annona muricata (Family-Annonaceae) fruit contain annonaceous acetogenins which have an effect on cancer cell as reported in many research studies. This study was aimed to evaluate the effect of methanolic fruit extract of Annona muricata (MFEAM) on breast cancer histology and invasive cell of MNU-induced breast cancer mice. Fifty female albino mice were divided into five groups (of ten each): control; MNU-induced breast cancer; MNU-induced breast cancer + (MFEAM) 200 mg/kg, MNU-induced breast cancer + (MFEAM) 300 mg/kg and MNU-induced breast cancer + (MFEAM) 500 mg/kg. The research indicates that breast cancer invasive ductal carcnoma (IDC) developed in the MNU-induced breast cancer group. The control group showed normal duct structure. The (MFEAM) -treated group showed lower invasive (DCIS) compared with the untreated cancer group. We concluded that (MFEAM), that improved the histological changes of breast cancer-induced MNU. Also (MFEAM) reduced proliferative epitheal cell of breast cancer-induced MNU and the most effective dose was 300 mg/kg. The present study concluded that the methanol extracts derived from Annona muricata fruit potentially exhibit antitumor activity. The control group showed normal duct structure. The (MFEAM) -treated group showed lower invasive (DCIS) compared with the untreated cancer group, We concluded (MFEAM) that improved the histological changes of breast cancer-induced MNU. Also (MFEAM) reduced proliferative epitheal cell of breast cancer-induced MNU and the most effective dose in 300 mg/kg.

show abstract

Section: Discussionmentioning

confidence: 99%

Histopathological Effect of Annona Muricata Fruit Extract on Methyl nitrosourea -Induced Mammary Gland Carcinoma in Female Albino Mice

Sabah Abdulhur,

Hamza Fares

2023

Kufa Jou. Vete. Med. Sci.

View full text Add to dashboard Cite

show abstract

“…Cancer is a genetic disorder that originates in singular cells; cumulative abnormalities in cellular genetics lead to cancer cells that undergo uncontrollable growth and divisions [27]. Somatic loss of both alleles of a tumor suppressor gene causes protein dysfunction, resulting in the loss of cellular regulatory function [28,29].…”

Section: Discussionmentioning

confidence: 99%

Exome Sequencing Reveals Novel Germline Variants in Breast Cancer Patients in the Southernmost Region of Thailand

Sukpan,

Sangkhathat,

Sriplung

et al. 2023

JPM

View full text Add to dashboard Cite

Germline carriers of pathogenic variants in cancer susceptibility genes are at an increased risk of breast cancer (BC). We characterized germline variants in a cohort of 151 patients diagnosed with epithelial BC in the southernmost region of Thailand, where the predominant ethnicity differs from that of the rest of the country. Whole exome sequencing was used to identify and subsequently filter variants present in 26 genes known to be associated with cancer predisposition. Of the 151 individuals assessed, 23, corresponding to 15.2% of the sample, exhibited the presence of one or more pathogenic or likely pathogenic variants associated with BC susceptibility. We identified novel germline truncating variants in BRIP1, CHEK2, MSH6, PALB2, and PTEN and annotated variants of uncertain significance (VUSs), both novel and previously documented. Therefore, it is advisable to use genetic testing as an additional risk screening method for BC in this area.

show abstract

“…The fact that only one to several out of trillions of targeted cells in the same animal are transformed early enough for the cells to develop to overt tumors signifies that the genetic manipulation as an artificial mutation has negligible efficacy in neoplastic transformation [6,138,275]. The discrepancy between 100% tumor penetrance at the animal level and the negligible transformation efficacy at the cellular level is reminiscent of the situation in the human being that "cancer is so common a disease yet so rare at a cellular level", as pointed out by Ferrell Jr et al [281]. Indeed, one of five people will likely develop cancer in his/her lifespan [142,143], which is horrible.…”

Section: Dissenting Evidence 4: Mutations Rarely Transform Cells In A...mentioning

confidence: 99%

Mutation or not, what directly establishes a neoplastic state, namely cellular immortality and autonomy, still remains unknown and should be prioritized in our research

Zhu¹,

Wang²,

Zellmer³

et al. 2022

J. Cancer

View full text Add to dashboard Cite

Why is cancer so common a disease in people yet so rare at a cellular level?

Cited by 4 publications

References 48 publications

Histopathological Effect of Annona Muricata Fruit Extract on Methyl nitrosourea -Induced Mammary Gland Carcinoma in Female Albino Mice

Histopathological Effect of Annona Muricata Fruit Extract on Methyl nitrosourea -Induced Mammary Gland Carcinoma in Female Albino Mice

Exome Sequencing Reveals Novel Germline Variants in Breast Cancer Patients in the Southernmost Region of Thailand

Mutation or not, what directly establishes a neoplastic state, namely cellular immortality and autonomy, still remains unknown and should be prioritized in our research

Contact Info

Product

Resources

About