Why is COVID-19 virus so deadly for cancer patients?

Yan, Sirui; Zhang, Ying; Liu, Qiuyun

doi:10.1097/cej.0000000000000605

Cited by 16 publications

(21 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This process is driven by the S2 unit undergoing dramatic conformational changes after activation to expose the receptor binding domain (RBD) [73] , [74] . Binding of the RBD to ACE-2 receptor leads to disconnection of the S1 from the S2 protein thereby promoting S2-mediated virus-host membrane fusion and viral entry [75] . Taking into account the crucial role of the RBD in this process it becomes an attractive target for treatment.…”

Section: Potential Biomarkers To Identify High Risk Patients and Targmentioning

confidence: 99%

SARS-CoV-2 and cancer: Are they really partners in crime?

Dam

Huizing

Mestach

et al. 2020

Cancer Treatment Reviews

View full text Add to dashboard Cite

Highlights Cancer patients with COVID-19 have a higher morbidity and mortality. Particularly patients with ongoing or recent cancer treatment, metastatic solid tumors and hematological malignancies are at risk. Underlying immunosuppression, elevated cytokine levels, altered expression of the angiotensin converting enzyme (ACE-2) and TMPRSS2, and a prothrombotic status in cancer patients may fuel the effects of a SARS-CoV-2 sepsis. The gene expression level of ACE2 may be an indicator of the susceptibility to SARS-CoV-2 infection, while TMPRSS2 plays a supporting role. Better knowledge of the mechanisms involved may be a tool to identify high risk patients and to prevent severe complications by targeting the involved pathways.

show abstract

Section: Potential Biomarkers To Identify High Risk Patients and Targmentioning

confidence: 99%

SARS-CoV-2 and cancer: Are they really partners in crime?

Dam

Huizing

Mestach

et al. 2020

Cancer Treatment Reviews

View full text Add to dashboard Cite

show abstract

“…Due to the presence of insoluble calcium oxalate, cancer patients and young people with constipation problems should be very cautious about the SARS-CoV-2 virus. (Yan et al, 2020;An et al, 2020a;Wan et al, 2019) Individuals with regular diarrhea might develop less severe symptoms as hydrogen bonding capacity allows the buildup of proton pool and acids, which are capable of solubilizing insoluble and rigid salts.…”

Section: Resultsmentioning

confidence: 99%

The Pneumonia Outbreak: High Isoleucine and High Valine Plus Glycine Contents Are Features of the Proteins of COVID-19 Virus

Wan¹,

Yan²,

Zhang³

et al. 2020

Preprint

Self Cite

View full text Add to dashboard Cite

The current pneumonia epidemic could evolve into a pandemic on a global scale if not effectively contained. The COVID-19 virus possesses a 61-amino acid open reading frame resembling SARS-CoV virulence factor - ORF6 peptide. The isoleucine content is 15.9% in ORF6 of SARS-CoV versus 16.4% of that in SARS-CoV-2. Given the proton affinity in the carbonyl oxygen in isoleucine, augmented proton traffic can enhance proton-ion antiport and prompt cell swelling. Calorie restriction has been confirmed in animal studies to extend lifespan, and its underlying mechanism is not fully known. As the content of essential amino acids in the open reading frame of SARS-CoV-2 reaches 57.4%, a starch/vitamin diet served for short period of time does not give rise to essential amino acids and halts virion production, which could be adopted as prophylactic approach of many viral infections. Plant-based diet or fasting/boiled rice water can also minimize the intake of essential amino acids or all amino acids respectively. Furthermore, several proteins of SARS-CoV-2 possess high valine plus glycine content which is implicated in heart disease, justifying the aforementioned approaches.

show abstract

“…This process is driven by the S2 unit undergoing dramatic conformational changes after activation to expose the receptor binding domain (RBD) [73,74]. Binding of the RBD to ACE-2 receptor leads to disconnection of the S1 from the S2 protein thereby promoting S2-mediated virus-host membrane fusion and viral entry [75]. Taking into account the crucial role of the RBD in this process it becomes an attractive target for treatment.…”

Section: Potential Biomarkers To Identify High Risk Patients and Targmentioning

confidence: 99%