Why is fatty liver unsuitable for transplantation? Deterioration of mitochondrial ATP synthesis and sinusoidal structure during cold preservation of a liver with steatosis

Fukumori, Tatsuya; Ohkohchi, Nobuhiro; Tsukamoto, Shigeki; Satoh, Susumu

doi:10.1016/s0041-1345(96)00158-3

Cited by 72 publications

(57 citation statements)

References 10 publications

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“…As fatty livers have a defective capability to synthesize ATP during post-ischemic reperfusion [6][7][8], mitochondrial dysfunction could be a major factor for the reduced tolerance of steatotic organs to preservation injury.…”

Section: Discussionmentioning

confidence: 99%

“…Alternatively, fatty degeneration, which induces a series of ultrastructural and biochemical alterations both in human and animal mitochondria [10 -13], may render these organelles intrinsically more susceptible to ischemia-reperfusion injury. However, although experimental observations suggest that the mitochondrial preservation injury is enhanced by steatosis [7,14,15], a systematic investigation of mitochondrial function in fatty liver exposed to cold ischemia and reperfusion is still lacking.…”

Section: Introductionmentioning

confidence: 99%

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Impairment of mitochondrial oxidative phosphorylation in rat fatty liver exposed to preservation-reperfusion injury

Caraceni¹,

Bianchi²,

Domenicali³

et al. 2004

Journal of Hepatology

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Impairment of mitochondrial oxidative phosphorylation in rat fatty liver exposed to preservation-reperfusion injury

Caraceni¹,

Bianchi²,

Domenicali³

et al. 2004

Journal of Hepatology

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“…39 Furthermore, animal studies have shown that fatty livers experience greater reduction in energy stores during cold storage and have a decreased capacity to restore ATP levels after reperfusion. 40 Additional factors contributing to the poor outcomes of fatty livers after transplantation may include Kupffer cell dysfunction, increased leukocyte adhesion, more vigorous lipid peroxidation, and ischemic necrosis of endothelial cells. 41 Steatotic livers have been associated with increased primary nonfunction 35,42,43 and initial poor graft function, although recoverable within the first week after liver transplantation.…”

Section: Steatotic Donorsmentioning

confidence: 99%

The utility of marginal donors in liver transplantation

Busuttil¹

2003

Liver Transplantation

630

508

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The shortage of organs has led centers to expand their criteria for the acceptance of marginal donors. The combination of multiple marginal factors seems to be additive on graft injury. In this review, the utility of various marginal donors in patients requiring liver transplantation will be described, including older donors, steatotic livers, non-heart-beating donors, donors with viral hepatitis, and donors with malignancies. The pathophysiology of the marginal donor will be discussed, along with strategies for minimizing the ischemia reperfusion injury experienced by these organs. Finally, new strategies for improving the function of the marginal/expanded donor liver will be reviewed. (Liver Transpl 2003;9:651-663.)

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“…These include impaired hepatic microcirculation [10] and decreased intracellular energy levels [11]. Impaired microcirculation may result from intra-cellular lipid accumulation, which increases cell volume.…”

Section: Introductionmentioning

confidence: 99%

Effect of Hepatic Steatosis on Bioenergetic Function During Hepatic Ischemia-reperfusion: A Systematic Review

Chu¹

2013

TOTRANSJ

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Abstract:Background: The impact of hepatic steatosis on bioenergetics following hepatic ischemia-reperfusion injury (IRI) remains controversial and is associated with variable reports on its outcome. Large numbers of studies have been published examining the relationship between hepatic steatosis and cellular bioenergetics following hepatic IRI. This systematic review evaluates these studies.Methods: An electronic search of the Medline and Embase databases (January 1946 to June 2012) was performed to select studies that reported relevant outcomes in animal models or patients with hepatic steatosis subjected to IRI.Results: A total of 489 articles were identified, of which 63 animal studies met the predefined criteria and were included in the study. There was large variation in the type of animal model, duration and type of IRI utilized and histological description of hepatic steatosis. Bioenergetic impairments appear to increase the susceptibility of steatotic livers to IRI. The most common impairment was decreased adenosine triphosphate recovery with increased oxidative stress following IRI. Impaired mitochondrial function play a key role in the susceptibility of steatotic livers to IRI.Conclusions: Animals with >30% hepatic steatosis have been shown to have poor outcome following IRI. Despite limitations of different experimental models and inconsistency in histological description, impaired mitochondrial function and bioenergetics appear to be important mediators in the decreased tolerance of steatotic livers to IRI. Future studies need to be consistent and clinically relevant to further improve our understanding of this issue.

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Why is fatty liver unsuitable for transplantation? Deterioration of mitochondrial ATP synthesis and sinusoidal structure during cold preservation of a liver with steatosis

Cited by 72 publications

References 10 publications

Impairment of mitochondrial oxidative phosphorylation in rat fatty liver exposed to preservation-reperfusion injury

Impairment of mitochondrial oxidative phosphorylation in rat fatty liver exposed to preservation-reperfusion injury

The utility of marginal donors in liver transplantation

Effect of Hepatic Steatosis on Bioenergetic Function During Hepatic Ischemia-reperfusion: A Systematic Review

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