Why is leukocytapheresis effective in inflammatory bowel diseases?

Kohgo, Yutaka

doi:10.1007/s00535-004-1509-4

Cited by 1 publication

(1 citation statement)

References 10 publications

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“…Previous reports suggested that LCAP was safe with few and minor adverse effects when used for some refractory autoimmune diseases [23, 24]. Interestingly, the counts of WBC and PMN decreased rapidly following LPS injection, which was consistent with an other report [25].…”

Section: Discussionsupporting

confidence: 90%

Peripheral Leukocytapheresis Attenuates Acute Lung Injury Induced by LipopolysaccharideIn Vivo

Zhang

Huang

Zhou

et al. 2012

Mediators of Inflammation

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The mortality of acute lung injury and acute respiratory distress syndrome (ALI/ARDS) remains high and efforts for prevention and treatments have shown little improvement over the past decades. The present study investigated the efficacy and mechanism of leukocytapheresis (LCAP) to partially eliminate peripheral neutrophils and attenuate lipopolysaccharide (LPS)-induced lung injury in dogs. A total of 24 healthy male mongrel dogs were enrolled and randomly divided into LPS, LCAP and LCAP-sham groups. All animals were injected with LPS to induce endotoxemia. The serum levels of leucocytes, neutrophil elastase, arterial blood gas, nuclear factor-kappa B (NF-κB) subunit p65 in lung tissues were measured. The histopathology and parenchyma apoptosis of lung tissues were examined. We found that 7, 3, and 7 animals in the LPS, LCAP, and sham-LCAP groups, respectively, developed ALI 36 h after LPS infusion. The levels of NF-κB p65 in lung tissue, neutrophils and elastase in blood, decreased significantly following LCAP. LCAP also alleviated apoptosis, and NF-κB p65 in lung tissues. Collectively, our results show that partial removal of leucocytes from peripheral blood decreases elastase level in serum. This, in turn, attenuates lung injuries and may potentially decrease the incidence of ALI.

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Section: Discussionsupporting

confidence: 90%