Why Is Otosclerosis of Low Prevalence in Japanese?

Ohtani, Iwao; Baba, Yoko; Suzuki, Chiaki; Kano, Makoto

doi:10.1097/00129492-200305000-00005

Cited by 34 publications

(20 citation statements)

References 7 publications

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“…About otosclerosis in Africa, there are only rare reports in the literature [2]. Early epidemiologic data suggested low frequency of otosclerosis among the Japanese population, but recent investigations showed an incidence similar to that in Europeans [5,6]. In the United States, 15 million people suffer from otosclerosis and it is considered to be among the most common causes of acquired deafness.…”

mentioning

confidence: 99%

Evidence of Increased Average Age of Patients with Otosclerosis

Niedermeyer

Häusler²,

Schwub³

et al. 2007

Otosclerosis and Stapes Surgery

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Otosclerosis is an inflammatory disease of the human temporal bone which was assumed to affect up to 10% of the Caucasians. Histologic otosclerosis has an incidence of 3.4%. It is considered as a major cause of hearing loss in Western countries while a low incidence is observed among Africans. Many hypotheses about its origin had been formulated in the past. Otosclerosis genes (OTSC1-5) and collagen 1 genes are mutated in some familial cases of otosclerosis. On this genetic background, a common environmental factor such as a measles virus infection might be the triggering factor. Studies in the past indicated a distribution of otosclerosis among men and women of 1:1.4. Our study was designed to analyze the age of patients with otosclerosis at the time of surgery in the eighties and the nineties of the last century. Patients suffering from clinical otosclerosis who underwent stapedectomy between 1978 and 1999 with complete clinical data available (n = 1,351) were included in the study. Age and gender distribution, the age difference between men and women and the influence of gender and the year of recruitment were evaluated. Statistical analyses demonstrated an increase in the average age of patients with clinical otosclerosis from the eighties to the nineties (p = 0.012). The gender distribution showed no statistically significant variation (p = 0.398). These data might reflect an improved health consciousness among the elder population or could be the result of increased health awareness in the seventies and eighties. Finally, in the early seventies, measles virus vaccination was introduced in Germany and the shift of age could be the result of the measles virus immunization campaign.

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mentioning

confidence: 99%

Evidence of Increased Average Age of Patients with Otosclerosis

Niedermeyer

Häusler²,

Schwub³

et al. 2007

Otosclerosis and Stapes Surgery

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“…On the other hand, in Japan, the ear surgery is performed during 2 weeks of hospitalization. The incidence of otosclerosis was much lower in Japan than in western countries [15]. We took good care of the patients after stapes surgery.…”

Section: Discussionmentioning

confidence: 99%

Taste disturbance after stapes surgery – clinical and experimental study

Miuchi¹,

Sakagami²,

Tsuzuki³

et al. 2009

Acta Oto-Laryngologica

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Conclusion: Most of the clinical cases experienced taste disturbance after stapes surgery, and in a few cases this disturbance persisted for a long time. The animal experiment suggested the role of geniculate ganglion (GG) cells in nerve generation. Objectives: To clinically examine taste disorder and its recovery after stapes surgery and experimentally demonstrate a role of GG. Patients and methods: Taste function after preservation of chorda tympani nerve (CTN) in stapes surgery was prospectively investigated with a questionnaire and electrogustometry (EGM). Further, expression of neurotrophic factors in GG after injury of CTN was examined by in situ hybridization histochemistry (ISSH) and RT-PCR. Results: Among the cases, 15/18 (83.3%) were associated with taste disturbance and 6/18 (33.3%) were associated with tongue numbness 2 weeks after surgery; however, the symptoms ceased in 14/18 cases (77.8%). Two weeks after surgery, the EGM threshold was found to be elevated in 15/18 cases (83.3%), while in 10/18 cases (55.6%), it did not decrease until 1 year after surgery. Expression of ISSH and amplified bands of BDNF and GFR increased at 7 and 14 days after nerve injury in ipsilateral GGs and also increased at 7 days on the contralateral side.

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“…Author(s) agree that this article remain permanently open access under the terms of the Creative Commons Attribution License 4.0 International License Minnesota Temporal collection is 12.5% in Caucasian and 1.5% in temporal bones of Japanese origin (Hueb et al, 1991;Ohtani et al, 2003). While the overall prevalence of histologic Otosclerosis is 10%, only 10% of these are clinically apparent making the overall prevalence of clinical otosclerosis approximately 1% in the population.…”

Section: Introductionmentioning

confidence: 93%

Temporal bone histopathology study on cochlear otosclerosis: A memoir for the cochlear implant surgeon

Ahmed¹

2019

Afr. J. Cell. Path

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The aim of this study was to describe the pathologic changes in temporal bones with cochlear otosclerosis that may have implications for cochlear implantation. Fifteen human temporal bones with otosclerosis were used for this study. In each temporal bone was studied: (1) medial wall of the middle ear and in particular the horizontal segment of the facial nerve canal; (2) the round window niche and the corresponding part of the scala tympani; (3) the area of the labyrinthine segment and first genu of the facial nerve. Six temporal bones revealed otosclerotic pathology spanning the otic capsule between the cochlear endosteum and the facial nerve canal. The labyrinthine facial nerve was enveloped by otosclerosis in two cases, while the horizontal segment was involved in four temporal bones. Complete obstruction of the round window niche was observed in three cases, while round window niche obstruction was observed in four temporal bones. Otosclerosis presents difficulties for implant candidates. These otosclerotic changes with obstruction are usually present at the round window or at the scala tympani. The histology described underpins the need to counsel patients regarding the possibility of facial nerve stimulation and difficult implantation.

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Why Is Otosclerosis of Low Prevalence in Japanese?

Cited by 34 publications

References 7 publications

Evidence of Increased Average Age of Patients with Otosclerosis

Evidence of Increased Average Age of Patients with Otosclerosis

Taste disturbance after stapes surgery – clinical and experimental study

Temporal bone histopathology study on cochlear otosclerosis: A memoir for the cochlear implant surgeon

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