Why isn’t cefadroxil used more often?

Computational drug repurposing for inflammatory bowel disease using genetic information

“… Drug Link to IBD Toxicity Cefadroxil Alanine aminopeptidase (ANPEP): Involved in the production and processing of pro-inflammatory cytokines (IFN- γ , IL-1 ß , IL-6, IL-8) [ 16 ] Peptide Transporter 1 (PEP1): Abnormally upregulated in colon of IBD patients; induces inflammation through uptake of bacterial peptides from commensal bacteria [ 17 ] Endothelin-1 Receptor (EDNRA): Enhances inflammation through recruitment of T lymphocytes and neutrophils, and release of pro-inflammatory and profibrotic cytokines [ 18 ]. Pregnane X Receptor (NR1l2): Shown to protect against IBD through dysregulation of the nuclear factor-κB signaling cascade [ 19 ] Mild Side effects (nausea, vomiting, diarrhea, abdominal pain may occur) [ 26 ] Propantheline Bromide Muscarinic acetylcholine receptor m1 (CHRM1): Muscarinic receptor antagonist that acts as a antispasmodic agent; not suitable for IBD overall [ 20 ] Mild side effects such as dry mouth, constipation and urinary retention [ 27 ] Severe side effects such as tachyarrhythmia, hallucinations, delirium, and cognitive impairment can occur [ 27 ] Lanatoside C Protein kinase C∂ (PRKCD): Involved in the regulation of several key IBD signaling pathways such as MAPK, NF-κB, c-Myc, and TNF- α [ 21 ] Can cause anorexia, nausea, vomiting, and neurological symptoms [ 28 ] Can rarely trigger fatal arrhythmias [ 28 ] Rifabutin Hsp90 (HSP90AA1, HSP90B1): downregulates pro-inflammatory cytokines IL-1b, IFN- γ and TNF- α [ 22 ] Mild side effects such as uveitis, rash, nausea, vomiting, neutropenia, anemia, discoloration of skin and body fluids [ 29 ] Liver impairment (rarely) [ 29 ] Dimethyloxalylglycine (DMOG) …”

First-Generation Cephalosporins for Treatment of Acute Hematogenous Osteomyelitis in Children: A Study of Efficacy and Adverse Effects

“…One concern with using cephalexin is that this higher frequency of dosing potentially reduces adherence [ 14 , 15 ]. Cefadroxil is another first-generation cephalosporin with the same antimicrobial spectrum of coverage and a similar adverse effect profile [ 16 , 17 ]. However, cefadroxil has the benefit of a slightly longer half-life, allowing for less frequent dosing of every 8 to 12 hours [ 16–19 ].…”

“…Cefadroxil is another first-generation cephalosporin with the same antimicrobial spectrum of coverage and a similar adverse effect profile [ 16 , 17 ]. However, cefadroxil has the benefit of a slightly longer half-life, allowing for less frequent dosing of every 8 to 12 hours [ 16–19 ]. One recently published single-center experience showed successful treatment of musculoskeletal infections with cefadroxil (30 mg/kg/d divided twice daily) [ 20 ].…”