2019
DOI: 10.1111/ijcp.13424
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Why knowing healthy controls matters

Abstract: Although healthy volunteers often serve as controls or primary participants in neuroscience research, they are usually less rigorously screened than patients, which can have far-reaching implications for interpretation of study results. Although this issue has long been recognized, it is rarely discussed in the research literature. This article examines how the rigorous screening and characterization of healthy volunteers is key for quality research.

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Cited by 5 publications
(5 citation statements)
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“…A special type of a control group are healthy participants; they are not always considered to be an actual control group (e.g., in Thibault et al (2018) ) since they perform the same task and receive actual feedback and therefore merely serve as a comparison group, but are nevertheless included in the present review for completeness. Although they pose a question of defining what exactly is a healthy participant ( Marchesini et al, 2017 , Pavletic, 2020 ) and may not in itself control for any clinical neurofeedback effects, they still do provide essential information regarding the “ideal/healthy” response or performance of the task or, in other words, confirm the effectiveness of the protocol. This is indeed important during the initial, feasibility stages of studies in order to verify that the task can be performed (e.g., the region can be controlled), but it becomes unnecessary in the later stages of trials.…”
Section: Resultsmentioning
confidence: 99%
“…A special type of a control group are healthy participants; they are not always considered to be an actual control group (e.g., in Thibault et al (2018) ) since they perform the same task and receive actual feedback and therefore merely serve as a comparison group, but are nevertheless included in the present review for completeness. Although they pose a question of defining what exactly is a healthy participant ( Marchesini et al, 2017 , Pavletic, 2020 ) and may not in itself control for any clinical neurofeedback effects, they still do provide essential information regarding the “ideal/healthy” response or performance of the task or, in other words, confirm the effectiveness of the protocol. This is indeed important during the initial, feasibility stages of studies in order to verify that the task can be performed (e.g., the region can be controlled), but it becomes unnecessary in the later stages of trials.…”
Section: Resultsmentioning
confidence: 99%
“…We speculated that such differences in rates could be related to the instruments used or to the way in which the cases and controls were recruited. For example, it has been argued that reliance on self-reports and non-use of objective measures may affect the quality of healthy controls 38 .…”
Section: Resultsmentioning
confidence: 99%
“…Naturally, the majority of the literature on MSWS-12 and MSIS-29 is for pwMS. However, it is necessary to take into account the variability in values on these PROMs within the general population [ 16 ]. Variability in MSWS-12 and MSIS-29 in people without MS (pwoMS) would indicate that medical conditions other than MS can influence scores on these PROMs.…”
Section: Introductionmentioning
confidence: 99%
“…Naturally, the majority of the literature on MSWS-12 and MSIS-29 is for pwMS. However, it is necessary to take into account the variability in values on these PROMs within the general population [16].…”
Section: Introductionmentioning
confidence: 99%