Why Omicron Variant of SARS‐CoV‐2 is Less Fatal?

Liao, Lipeng; Zhang, Jiaming; Wang, Yuchuan; Liu, Qiuyun

doi:10.1002/cbic.202200158

Cited by 11 publications

(19 citation statements)

References 18 publications

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“…24 3 THE CLOCK SPRING OF AGING Generally, the replacement of glycine and valine by other amino acids in the above-mentioned longevity genes leads to longer lifespan, [25][26] due to the fact that the decrease of number of glycine and valine residues lowers the total affinity of the protein to calcium, consequently slowing down the formation of stressful calcium oxalate and perhaps other insoluble salts. The positively charged arginine residue can bind and transport anions such as oxalate as well as calcium 17,18 , and its substitutions prolonged life expectancy. 25 There is an exception: the I405V polymorphism of the CETP gene has been demonstrated to give rise to longevity in Ashkenazi Jews, in contradictory to findings in some other human populations.…”

Section: The Ticking Aging Clock: Are Valine and Glycine The Oscillat...mentioning

confidence: 99%

Aging and age-related diseases

Zhang¹,

Ouyang²,

Tang³

et al. 2023

Preprint

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Various mechanisms have been proposed, and a molecular perspective is much awaited to account for the observed phenomena regarding aging and death. Valine and glycine are overrepresented in numerous causative factors of heart disease and Alzheimer’s disease, as well as in proteins of SARS-CoV-2 strains causing the current pandemic. Both amino acids have long carbonyl bond lengths and thus possess affinities to divalent cations, promoting the formation of insoluble salts. The insoluble and stiff calcium oxalate is stressful to cells and triggers cell senescence. Consequently valine plus glycine content can serve as a ticking aging clock as longevity genes generally encode proteins rich in valine plus glycine. Given the common characteristics of the longevity gene products, aging process may be intervened by diet, exercise and lifestyle.

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Section: The Ticking Aging Clock: Are Valine and Glycine The Oscillat...mentioning

confidence: 99%

Aging and age-related diseases

Zhang¹,

Ouyang²,

Tang³

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

“…[25] Interestingly, valine plus glycine content is high in SARS and SARS-CoV-2 proteins, and in causative factors of heart disease and Alzheimer's disease. [20][21][22][23][24] Insoluble and rigid calcium salts and hydrogen bonding exhibit mutual antagonism chemically and biochemically [27][28][29] , which might account for the lack of effects of asthma on COVID-19.…”

Section: Hydrogen Bonding To Water and Protons And Cell Swellingmentioning

confidence: 99%

Why cellulose and materials derived from cellulose with abundant hydrogen bonding are anti-allergic and alleviate asthma?

Zhang¹,

Wang²,

Liu³

2022

Preprint

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Allergic disorders cause widespread morbidity and mortality, posing pressure on the current medical system and affected families. The risk for allergy was reported to be lower in the countryside than in urban settings, with gut bacterial diversity lower in the affected individuals. A comprehensive theory is not yet established to account for numerous observed phenomena. Here we propose a biochemical mechanism, in which allergens possess hydrogen bond capacity and interact with antibodies. During allergic response, release of histamine with multiple hydrogen bonding capacity can interact with several water molecules via nitrogen and amino- and imino-hydrogen, consequently triggering hydroncus. As a case in point, cellulose and materials derived from cellulose with abundant hydrogen bonding possess protective effects on allergy and asthma in previous studies, perhaps shielding allergen from binding to antibodies. The biochemical perspective can further our understanding of the disorders and merit future investigations.

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“…The tumor expansion from recombinant Poliovirus therapy initially [1] may be resulted from the solubilization of the stiff calcium oxalate and calcium phosphate by acids in the rigid and compact neoplastic tissues leading to tumor volume increase, which was consequently more easily accessed by cytokines from viral-induced immune response. Hydrogen bonding can disrupt secondary chemical bonding of non-proton cations, and vice versa [8][9][10].…”

mentioning

confidence: 99%

Why recombinant Poliovirus possesses anticancer property?

ShanShan,

Lin,

et al. 2022

Preprint

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Genomic instability is a hallmark of tumorigenesis. Some viruses have been demonstrated to possess antineoplastic property. Viruses trigger immune responses upon infections, but not all viruses have been reported to boast robust anticancer effects. What molecular features can be found in these anti-neoplasm viral agents? These viruses may share characteristics with antimicrobial and anticancer peptides, such as content of particular amino acids, rendering viral protein fragments cytolytic or inhibitory to cell growth. The divalent cation-binding characteristic of valine and glycine can not only prompt cell death but also avert DNA damage, which ensured no cancer deterioration during tumor treatment. The moderate content of hydrogen bond donors and acceptors in the proteins of Poliovirus confers acid susceptibility of tumor but avoids DNA mutagenesis in the presence of cation-binding amino acid residues.

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Why Omicron Variant of SARS‐CoV‐2 is Less Fatal?

Cited by 11 publications

References 18 publications

Aging and age-related diseases

Aging and age-related diseases

Why cellulose and materials derived from cellulose with abundant hydrogen bonding are anti-allergic and alleviate asthma?

Why recombinant Poliovirus possesses anticancer property?

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