Clinical decision-making encompasses a broad set of processes that contribute to the effectiveness of depression treatments. There is emerging interest in using digital technologies to support effective and efficient clinical decision-making. In this paper, we provide ‘snapshots’ of research and current directions on ways that digital technologies can support clinical decision-making in depression treatment. Practical facets of clinical decision-making are reviewed, then research, design, and implementation opportunities where technology can potentially enhance clinical decision-making are outlined. Discussions of these opportunities are organized around three established movements designed to enhance clinical decision-making for depression treatment, including measurement-based care, integrated care, and personalized medicine. Research, design, and implementation efforts may support clinical decision-making for depression by (a) improving tools to incorporate depression symptom data into existing electronic health record systems, (b) enhancing measurement of treatment fidelity and treatment processes, (c) harnessing smartphone and biosensor data to inform clinical decision-making, (d) enhancing tools that support communication and care coordination between patients and providers and within provider teams, and (e) leveraging treatment and outcome data from electronic health record systems to support personalized depression treatment. The current climate of rapid changes in both healthcare and digital technologies facilitates an urgent need for research, design, and implementation of digital technologies that explicitly support clinical decision-making. Ensuring that such tools are efficient, effective, and usable in frontline treatment settings will be essential for their success and will require engagement of stakeholders from multiple domains.