The LAmbre occluder is more convenient to operate than other left atrial
appendage closures(LAAC), and it can adapt to different anatomy of left
atrial appendage. However, some studies showed that Lambre occluder had
a higher incidence of device-related thrombus(DRT). This meta-analysis
aims to compare the safety and efficacy of the LAmbre occluder with
other LAAC devices. Eligible studies were retrieved from PubMed, Embase
and the Cochrane Library up to 1 July 2022 and reported the results.
Five studies of a total of 607 patients were included in the
meta-analysis. The LAmbre occluder was associated with higher rate of
DRT(OR [95% CI] = 5.25 [1.21, 22.86], P =0.03; I2=0%). No
significant differences were observed in the incidence of
procedure-related death, pericardial effusion, chest pain, bleeding and
vessel complication, contrast medium, fluoroscopy time ,death, stroke,
bleeding events, systemic embolism and peri-device leakage. In
conclusion, the LAmbre occluder had higher incidence of DRT than other
LAAC devices, and there were no significant differences in stroke,
bleeding events, and mortality.