Why Should My Mouse Call Me? Acoustic Communication in Mouse Models of Social Disorders: Ultrasonic Vocalizations as an Index of Emotional and Motivational States

Granon, Sylvie; Faure, Alexis; Chauveau, Frédéric; Cressant, Arnaud; Ey, Elodie

doi:10.1016/b978-0-12-809600-0.00040-8

Cited by 17 publications

(14 citation statements)

References 80 publications

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“…Ultrasonic vocalizations (USV) of laboratory rodents represent age-dependent indicators of animal emotional arousal [1][2][3][4][5][6] and may serve for modeling human diseases and the evaluation of drugs and medicaments effects [7][8][9][10][11][12][13][14][15][16][17][18][19][20]. The overwhelmingly preferred mice USV model [1,8,10,[21][22][23][24] is applicable for USV ontogeny [7,16,19,20,[25][26][27][28][29][30][31][32][33].…”

Section: Introductionmentioning

confidence: 99%

Rapid development of mature vocal patterns of ultrasonic calls in a fast-growing rodent, the yellow steppe lemming (Eolagurus luteus)

Yurlova

Volodin

Ilchenko³

et al. 2020

PLoS ONE

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Ultrasonic vocalizations (USV) of laboratory rodents may serve as age-dependent indicators of emotional arousal and anxiety. Fast-growing Arvicolinae rodent species might be advantageous wild-type animal models for behavioural and medical research related to USV ontogeny. For the yellow steppe lemming Eolagurus luteus, only audible calls of adults were previously described. This study provides categorization and spectrographic analyses of 1176 USV calls emitted by 120 individual yellow steppe lemmings at 12 age classes, from birth to breeding adults over 90 days (d) of age, 10 individuals per age class, up to 10 USV calls per individual. The USV calls emerged since 1 st day of pup life and occurred at all 12 age classes and in both sexes. The unified 2-min isolation procedure on an unfamiliar territory was equally applicable for inducing USV calls at all age classes. Rapid physical growth (1 g body weight gain per day from birth to 40 d of age) and the early (9-12 d) eyes opening correlated with the early (9-12 d) emergence of mature vocal patterns of USV calls. The mature vocal patterns included a prominent shift in percentages of chevron and upward contours of fundamental frequency (f0) and the changes in the acoustic variables of USV calls. Call duration was the longest at 1-4 d, significantly shorter at 9-12 d and did not between 9-12-d and older age classes. The maximum fundamental frequency (f0max) decreased with increase of age class, from about 50 kHz in neonates to about 40 kHz in adults. These ontogenetic pathways of USV duration and f0max (towards shorter and lower-frequency USV calls) were reminiscent of those in laboratory mice Mus musculus.

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Section: Introductionmentioning

confidence: 99%

Rapid development of mature vocal patterns of ultrasonic calls in a fast-growing rodent, the yellow steppe lemming (Eolagurus luteus)

Yurlova

Volodin

Ilchenko³

et al. 2020

PLoS ONE

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“…Mice have been used as a comparative auditory model to investigate hearing loss Kobrina and Dent, 2016;Lauer et al, 2012;Liberman and Kujawa, 2017) and communication disorders (Granon et al, 2018) because of the powerful genetic technologies available to manipulate the neural circuits involved in audition. Mice rely on audition for communication, since both female and male mice produce ultrasonic vocalizations (USVs) during mating and other social situations, with frequencies of up to 110 kHz (Hoffmann et al, 2012a;Mahrt et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Best sensitivity of temporal modulation transfer functions in laboratory mice matches the amplitude modulation embedded in vocalizations

Cai

Dent

2020

The Journal of the Acoustical Society of America

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The perception of spectrotemporal changes is crucial for distinguishing between acoustic signals, including vocalizations. Temporal modulation transfer functions (TMTFs) have been measured in many species and reveal that the discrimination of amplitude modulation suffers at rapid modulation frequencies. TMTFs were measured in six CBA/CaJ mice in an operant conditioning procedure, where mice were trained to discriminate an 800 ms amplitude modulated white noise target from a continuous noise background. TMTFs of mice show a bandpass characteristic, with an upper limit cutoff frequency of around 567 Hz. Within the measured modulation frequencies ranging from 5 Hz to 1280 Hz, the mice show a best sensitivity for amplitude modulation at around 160 Hz. To look for a possible parallel evolution between sound perception and production in living organisms, we also analyzed the components of amplitude modulations embedded in natural ultrasonic vocalizations (USVs) emitted by this strain. We found that the cutoff frequency of amplitude modulation in most of the individual USVs is around their most sensitive range obtained from the psychoacoustic experiments. Further analyses of the duration and modulation frequency ranges of USVs indicated that the broader the frequency ranges of amplitude modulation in natural USVs, the shorter the durations of the USVs. V

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“…For example, the presence of complex and harmonic calls has been considered as a valuable index of positive emotions in mice 77 . Crucially, emotional and motivational aspects play a role in modulating the number of USVs and the type of call in several mouse models of psychiatric disorders, as autism spectrum disorders, schizophrenia, and stress‐related disorders 78 . Comparing the use of call types by different strains, B6 mice disproportionally emitted higher pitch and more downward modulated calls than BALB mice during vigorous social approaches 11 .…”

Section: Discussionmentioning

confidence: 99%

Ultrasonic vocalizations in laboratory mice: strain, age, and sex differences

Caruso

Marconi

Scattoni

et al. 2022

Genes Brain and Behavior

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Mice produce ultrasonic vocalizations (USVs) in different social contexts across lifespan. There is ethological evidence that pup USVs elicit maternal retrieval and adult USVs facilitate social interaction with a conspecific. Analysis of mouse vocal and social repertoire across strains, sex and contexts remains not well explored. To address these issues, in inbred (C57BL/6, FVB) and outbred (CD‐1) mouse strains, we recorded and evaluated USVs as neonates and during adult social encounters (male–female and female–female social interaction). We showed significant strain differences in the quantitative (call rate and duration of USVs) and qualitative vocal analysis (spectrographic characterization) from early stage to adulthood, in line with specific patterns of social behaviors. Inbred C57BL/6 mice produced a lower number of calls with less internal changes and shorter duration; inbred FVB mice displayed more social behaviors and produced more syllables with repeated internal changes; outbred CD‐1 mice had an intermediate profile. Our results suggest specific vocal signatures in each mouse strain, thus helping to better define socio‐communicative profiles of mouse strains and to guide the choice of an appropriate strain according to the experimental settings.

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Why Should My Mouse Call Me? Acoustic Communication in Mouse Models of Social Disorders: Ultrasonic Vocalizations as an Index of Emotional and Motivational States

Cited by 17 publications

References 80 publications

Rapid development of mature vocal patterns of ultrasonic calls in a fast-growing rodent, the yellow steppe lemming (Eolagurus luteus)

Rapid development of mature vocal patterns of ultrasonic calls in a fast-growing rodent, the yellow steppe lemming (Eolagurus luteus)

Best sensitivity of temporal modulation transfer functions in laboratory mice matches the amplitude modulation embedded in vocalizations

Ultrasonic vocalizations in laboratory mice: strain, age, and sex differences

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