Why so null? Methodologic necessities to advance endometriosis discovery

Missmer, Stacey A.

doi:10.1111/ppe.12540

Cited by 16 publications

(8 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, this study was based on 86 endometriosis cases and 21 controls who had received surgery for other indications (i.e. myomectomy, tubal ligation), which may have biased the results toward the null if the surgical indications were also associated with telomere length [14]. Another study measured TL in endometrial tissue and peripheral blood among endometriosis cases (n = 29) and in controls (n = 27) who were receiving laparoscopic surgery for tubal ligation [13].…”

Section: Discussionmentioning

confidence: 99%

“…While the investigators did not observe a statistically significant association between LTL and endometriosis, the small sample size limited their ability to observe any significant results. In addition, since parity has been reported to be associated with shorter telomere length [28], using multiparous controls who had tubal ligation would likely bias the results toward the null given that a high proportion of the women with endometriosis are likely to be nulliparous, [14].…”

Section: Discussionmentioning

confidence: 99%

“…However, these studies were both small in sample size and used surgical control groups (i.e. women who underwent surgery for other gynecologic indications) to examine the associations, which could have erroneously attenuated the observed associations [14]. Here, we examined the association between peripheral blood LTL and self-reported endometriosis using data from two population-based studies.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Peripheral Blood Leukocyte Telomere Length and Endometriosis

et al. 2020

Self Cite

View full text Add to dashboard Cite

Endometriosis is a common gynecologic disease defined by the presence of endometrial-like tissue outside the uterine cavity. While its etiology is largely unknown, accumulating evidence suggests inflammation plays a major role. Our objective was to investigate the association between peripheral blood leukocyte telomere length (LTL) and endometriosis using data from two large population-based studies, the New England Case-Control Study (NEC; n=877) and the National Health and Nutrition Examination Survey (NHANES; n=2,268). NEC control participants were

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Peripheral Blood Leukocyte Telomere Length and Endometriosis

et al. 2020

Self Cite

View full text Add to dashboard Cite

show abstract

“…Presently, no reliable biomarkers exist for non-invasive diagnosis of endometriosis [5,6]. Though many attempts have been made to identify and validate specific biomarkers, studies have been conducted mostly in adult populations limited by poor methodological quality including small sample sizes, lack of consideration of disease heterogeneity, and inappropriate control groups [6,7].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of CA125 in relation to pain symptoms among adolescents and young adult women with and without surgically-confirmed endometriosis

et al. 2020

Self Cite

View full text Add to dashboard Cite

Endometriosis is a painful gynecologic disease affecting one in ten reproductive aged women worldwide. Few studies have correlated this symptomatology with biomarker levels among women with and without endometriosis, and no studies correlating pain with biomarker levels have been performed in young patient populations. The purpose of this study was to examine whether CA125 correlates with different types and severity of pain among adolescents and young women with and without endometriosis and assess its performance as an endometriosis biomarker among those presenting with dysmenorrhea in this young population. Reproductive-aged women with laparoscopically-confirmed endometriosis (n = 282) and controls (n = 293) who participated in The Women's Health Study: From Adolescence to Adulthood (A2A), a cohort of adolescents and young women enrolled from 2012-2018, were included in this cross-sectional analysis. Plasma CA125 values were measured using WERF EPHect compliant blood samples collected at enrollment. Average CA125 were calculated by self-reported pain type (i.e. dysmenorrhea, non-cyclic/general pelvic pain, dyspareunia), severity, and frequency in endometriosis cases and controls. Median age at blood draw was 24 years in controls and 17 years in cases, with 68% and 89% non-Hispanic white, respectively. Most endometriosis cases (95%) were rASRM stage I/II. Average CA125 values were 12.5 U/mL in controls and 12.1 U/mL in cases adjusted for age. CA125 did not differ by pain type, its severity, or frequency in endometriosis cases or controls. Among participants who reported dysmenorrhea, CA125 did not discriminate endometriosis cases from controls using cutoff of 35 U/mL (AUC = 0.51, 95%CI = 0.50-0.53). Among adolescents and young adult women, CA125 did not correlate with pain type. CA125

show abstract

“…Beyond that, there are also variations of the disease such as the size of the abnormal tissue area(s), level of pain described by women, and different means of treatment. Due to the many variations of this disease, it can take many doctor visits over a range of years for women to receive a proper diagnosis and an effective treatment plan [3,9].…”

Section: Introductionmentioning

confidence: 99%

Need-Based Holistic Treatments for Endometriosis in Women

2020

IJWHC

View full text Add to dashboard Cite

Endometriosis is a debilitating disease that affects approximately 200 million women across the globe [1]. There are numerous difficulties in assessing the number of women who suffer from this disease including insufficient diagnostics, under-reporting, and the lack of recognition of chronic pain in women. Although some mainstream treatments exist, which are considered to be “traditional” such as pharmaceuticals aimed at hormone control and pain reduction, there is no one-size-fits all approach that works for all women, and as of now, there is no known cure for the disease. This paper aims to share other potential treatments for endometriosis and similar female reproductive diseases which cause chronic pain. Further, the aim is to urge a multidisciplinary approach by medical practitioners, physical therapists, practitioners of Eastern, ancient, and spiritual healing and holistic medicines, and others who can combine their areas of expertise to create a wider encompassing treatment plan that considers both the physical and mental aspects of this disease.

show abstract

Why so null? Methodologic necessities to advance endometriosis discovery

Cited by 16 publications

References 10 publications

Peripheral Blood Leukocyte Telomere Length and Endometriosis

Peripheral Blood Leukocyte Telomere Length and Endometriosis

Evaluation of CA125 in relation to pain symptoms among adolescents and young adult women with and without surgically-confirmed endometriosis

Need-Based Holistic Treatments for Endometriosis in Women

Contact Info

Product

Resources

About