Why the IOM recommendations for vitamin D are deficient

Heaney, Robert P.; Holick, Michael F.

doi:10.1002/jbmr.328

Cited by 333 publications

(250 citation statements)

References 12 publications

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“…The NAMÕs RDA [defined as the intake likely to ''meet or exceed the needs of about 97.5% of the population'' (7)] is 600 and 800 IU/d for those aged #70 and >70 y, respectively. Supplementation with 1000 IU/d did not meet the NAM target in our participants, a finding that is consistent with the assertion that the RDA may not achieve its target in the general population (64,65). However, this finding was not adjusted for potential confounding (e.g., by season), and our population had special characteristics that may affect generalizability, including a history of colorectal adenoma (but not familial polyposis syndromes), the exclusion of vitamin D-deficient participants (serum 25(OH)D concentration <12 ng/mL), a lower prevalence of minorities (18% compared with 28%), and a higher prevalence of overweight participants (78% compared with 72%) than in the general population (66,67).…”

Section: Discussionsupporting

confidence: 89%

Lifestyle and Other Factors Explain One-Half of the Variability in the Serum 25-Hydroxyvitamin D Response to Cholecalciferol Supplementation in Healthy Adults

Rees

Mott

Barry

et al. 2016

The Journal of Nutrition

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Section: Discussionsupporting

confidence: 89%

Lifestyle and Other Factors Explain One-Half of the Variability in the Serum 25-Hydroxyvitamin D Response to Cholecalciferol Supplementation in Healthy Adults

Rees

Mott

Barry

et al. 2016

The Journal of Nutrition

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“…As discussed in a recent paper, most such studies are anomalous and, when combined with other similar studies, the effect disappears (Grant, 2009f). Several editorials and letters to editors have criticized the IOM report (Grant, 2011b;Heaney and Holick, 2011;Holick, 2011).…”

Section: Multiple Sclerosismentioning

confidence: 96%

An estimate of the global reduction in mortality rates through doubling vitamin D levels

Grant

2011

Eur J Clin Nutr

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Background/Objectives: The goal of this work is to estimate the reduction in mortality rates for six geopolitical regions of the world under the assumption that serum 25-hydroxyvitamin D (25(OH)D) levels increase from 54 to 110 nmol/l. Subjects/Methods: This study is based on interpretation of the journal literature relating to the effects of solar ultraviolet-B (UVB) and vitamin D in reducing the risk of disease and estimates of the serum 25(OH)D level-disease risk relations for cancer, cardiovascular disease (CVD) and respiratory infections. The vitamin D-sensitive diseases that account for more than half of global mortality rates are CVD, cancer, respiratory infections, respiratory diseases, tuberculosis and diabetes mellitus. Additional vitamin D-sensitive diseases and conditions that account for 2 to 3% of global mortality rates are Alzheimer's disease, falls, meningitis, Parkinson's disease, maternal sepsis, maternal hypertension (pre-eclampsia) and multiple sclerosis. Increasing serum 25(OH)D levels from 54 to 110 nmol/l would reduce the vitamin D-sensitive disease mortality rate by an estimated 20%. Results: The reduction in all-cause mortality rates range from 7.6% for African females to 17.3% for European females. Reductions for males average 0.6% lower than for females. The estimated increase in life expectancy is 2 years for all six regions. Conclusions: Increasing serum 25(OH)D levels is the most cost-effective way to reduce global mortality rates, as the cost of vitamin D is very low and there are few adverse effects from oral intake and/or frequent moderate UVB irradiance with sufficient body surface area exposed.

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“…There is a consensus that 25(OH)D (calcidiol) is the most abundant metabolite and the best indicator for the evaluation of vitamin D status (A), the indivi duals being classified as: deficient, insufficient of suf ficient in vitamin D (3,6,41,42). On the other hand, there is no consensus regarding the cut off value for the definition of "vitamin D sufficiency" (6,43,44).…”

Section: What Are the Effects On Bone Metabolism?mentioning

confidence: 99%

Recomendações da Sociedade Brasileira de Endocrinologia e Metabologia (SBEM) para o diagnóstico e tratamento da hipovitaminose D

Maeda

Borba

Camargo

et al. 2014

Arq Bras Endocrinol Metab

227

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Objective: The objective is to present an update on the diagnosis and treatment of hypovitaminosis D, based on the most recent scientific evidence. Materials and methods: The Department of Bone and Mineral Metabolism of the Brazilian Society of Endocrinology and Metabology (SBEM) was invited to generate a document following the rules of the Brazilian Medical Association (AMB) Guidelines Program. Data search was performed using PubMed, Lilacs and SciELO and the evidence was classified in recommendation levels, according to the scientific strength and study type. Conclusion: A scientific update regarding hypovitaminosis D was presented to serve as the basis for the diagnosis and treatment of this condition in Brazil.

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Why the IOM recommendations for vitamin D are deficient

Abstract: The IOM recommendations for vitamin D fail in a major way on logic, on science, and on effective public health guidance. Moreover, by failing to use a physiological referent, the IOM approach constitutes precisely the wrong model for development of nutritional policy. ß

Cited by 333 publications

References 12 publications

Lifestyle and Other Factors Explain One-Half of the Variability in the Serum 25-Hydroxyvitamin D Response to Cholecalciferol Supplementation in Healthy Adults

Lifestyle and Other Factors Explain One-Half of the Variability in the Serum 25-Hydroxyvitamin D Response to Cholecalciferol Supplementation in Healthy Adults

An estimate of the global reduction in mortality rates through doubling vitamin D levels

Recomendações da Sociedade Brasileira de Endocrinologia e Metabologia (SBEM) para o diagnóstico e tratamento da hipovitaminose D

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