Why we still use intravenous drugs as the basic regimen for neurosurgical anaesthesia

Hans, Pol; Bonhomme, Vincent

doi:10.1097/01.aco.0000245274.69292.ad

Cited by 121 publications

(60 citation statements)

References 54 publications

(44 reference statements)

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“…The animals were initially anesthetized by propofol, which was suggested to have a minimal influence on evoked potentials monitoring in human surgery [21]. From our findings, the porcine mfERG under propofol anesthesia (Fig.…”

Section: Anesthesiamentioning

confidence: 88%

Pharmacologically defined components of the normal porcine multifocal ERG

Chan

Chu

et al. 2007

Doc Ophthalmol

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Multifocal electroretinograms (mfERG) from isoflurane anesthetized pigs were recorded and sequential application of TTX, NMDA, APB and PDA were used to identify contributions to the mfERG from inner retinal neurons, ON-pathway, OFF-pathway and photoreceptors. The cellular origins of the first-order kernel (K1) and the first slice of the second-order kernel (K2.1) porcine mfERG are contributed from both inner and outer retina. For the K1 waveform, the n1 involved responses of cone photoreceptors and OFF-bipolar cells. The leading edge of p1 is dominated by ON-bipolar cell depolarization. The rear edge of p1, n2 and p2 are dominated by ON-bipolar activities and shaped by the activities of OFF-bipolar cells and retinal cells with NMDAr and voltage-gated sodium channels other than ganglion cells. The p3 is mainly inner retinal activities. For the K2.1 waveform, the p1 and n1 are the summation of activities of ON-, OFF-bipolar cells and retinal cells rich in NMDAr and voltage-gated sodium channels other than ganglion cells. The p2 seems to be related to the ganglion cells. Better understanding of the cellular origins of the normal porcine mfERG will be useful for comparing and defining the functional changes that may occur in diseased retinas.

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Section: Anesthesiamentioning

confidence: 88%

Pharmacologically defined components of the normal porcine multifocal ERG

Chan

Chu

et al. 2007

Doc Ophthalmol

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“…Of these, propofol is one of the most promising agents in mediating neuroprotection after hypoxicischemic insults in adult patients and animals (15)(16)(17)(18). However, in the developing brain, anesthetic agents have also been shown to induce apoptosis in newborn animal models (19).…”

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confidence: 99%

Functional impairment of the auditory pathway after perinatal asphyxia and the short-term effect of perinatal propofol anesthesia in lambs

et al. 2013

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Background: Sensorineural hearing loss (SNHL) is a common feature in the postasphyxial syndrome in newborns. Several anesthetic drugs have been proposed to attenuate secondary neuronal injury elicited by hypoxia-ischemia. We hypothesized that propofol anesthesia reduces auditory impairment after perinatal asphyxia in comparison with isoflurane. Methods: Twenty-three pregnant ewes were randomized to propofol or isoflurane anesthesia and sedation. The lambs underwent in utero umbilical cord occlusion (isoflurane n = 5; propofol n = 7) and were compared with sham-treated animals (isoflurane n = 5; propofol n = 6) at a gestational age of 133 d. For 8 h after delivery by cesarean section, repeated auditory brainstem responses (ABRs) were recorded to obtain hearing thresholds, peak amplitudes, latencies, and interpeak latencies. results: Significantly elevated mean thresholds, diminished amplitudes, and elevated latencies were observed in the asphyxia group relative to the control group through the observation period. Comparison of anesthetic treatment in the asphyxia group revealed a significantly lower elevation in threshold and less impairment in the ABR amplitudes and latencies during propofol anesthesia as compared with isoflurane anesthesia. conclusion: Our results support the hypothesis that anesthesia with propofol has a preventive effect on the functional changes to the auditory pathway in the event of perinatal asphyxia.

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“…It has a neuroprotective effect during cerebral ischemia, lowering intracranial pressure, cerebral blood flow, cerebral metabolism and oedema, and improving cerebral perfusion pressure and mean arterial pressure (MAP). [20][21][22] However, propofol has a narrow therapeutic index and lacks intrinsic analgesic properties. Patients generally receive a combination of anesthetic and analgesic agents to induce and maintain an adequate depth of anesthesia and analgesia.…”

Section: Discussionmentioning

confidence: 99%

A comparative study of total intravenous anesthesia with propofol/ketamine and propofol/tramadol combinations in orthopedic outpatient procedures

Kanchanpally¹,

Nagawaram²

2015

Int J Basic Clin Pharmacol

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Why we still use intravenous drugs as the basic regimen for neurosurgical anaesthesia

Abstract: Although all the objectives of neurosurgical anaesthesia cannot be met by one single anaesthetic agent or technique, propofol-based intravenous anaesthesia appears as the first choice to challenge the evolution of neurosurgery in the third millennium.

Cited by 121 publications

References 54 publications

Pharmacologically defined components of the normal porcine multifocal ERG

Pharmacologically defined components of the normal porcine multifocal ERG

Functional impairment of the auditory pathway after perinatal asphyxia and the short-term effect of perinatal propofol anesthesia in lambs

A comparative study of total intravenous anesthesia with propofol/ketamine and propofol/tramadol combinations in orthopedic outpatient procedures

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